Results 101 to 110 of about 2,157,984 (211)
Matrine–Tea Saponin Synergism Involves Suppressed Detoxification and Digestion in a Leaf Beetle
Integrative Zoology, EarlyView.Tea saponin and matrine showed synergistic toxicity against Plagiodera versicolora. Combined exposure suppressed digestion‐ and detoxification‐related processes, while silencing the trypsin gene Pver105950 and chitinase gene Pver001190 increased larval susceptibility to tea saponin and matrine, respectively.
Owais Khan +4 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff +3 more
wiley +1 more source
Identification of whole-cell dsRNA-binding proteins by phase separation
RNA BiologyInteractions between double-stranded RNA (dsRNA) and proteins play an important role in cellular homeostasis by regulating the editing, stability, and splicing of intracellular RNA.
Zhixiang Yang +6 more
doaj +1 more source
Feiwei Heji Enhances Antitumor Immunity by MLL4‐Dependent Regulation of Pyroptosis in Lung Cancer
Cancer Science, EarlyView.Feiwei Heji suppresses lung tumor growth by downregulating MLL4 and activating caspase‐1/GSDMD‐associated pyroptosis. This pyroptosis‐related inflammatory response enhances CD8+ T‐cell‐mediated antitumor immunity, revealing an MLL4‐pyroptosis‐immune axis underlying the therapeutic activity of Feiwei Heji.
Nan Cheng +6 more
wiley +1 more source
Design of RNAi reagents for invertebrate model organisms and human disease vectors [PDF]
, 2011 RNAi has become an important tool to silence gene expression in a variety of organisms, in particular when classical genetic methods are missing. However, application of this method in functional studies has raised new challenges in the design of RNAi ...
Thomas Horn, Michael Boutros
core
Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens
Cell Proliferation, EarlyView.In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu +8 more
wiley +1 more source
Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR
MoleculesGender control technologies are promising for enhancing the production efficiency of the farm animal industry, and preventing sex-linked hereditary diseases in humans.
Yunfei Hou +5 more
doaj +1 more source
Impacts of a flea beetle double-stranded RNA-based insecticide on the ground beetle Pterostichus melanarius [PDF]
Flea beetles (Phyllotreta cruciferae and P. striolata) are the most damaging insect pests of canola, one of Canada’s most economically valuable crops. Chemical insecticides are currently the primary method of flea beetle control, but concerns about their
Lampimaki, Silas
core
Cell Proliferation, EarlyView.In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu +6 more
wiley +1 more source
RNA activation in insects: From emerging evidence to molecular applications
Insect Molecular Biology, EarlyView.Canonical RNA activation involves small RNAs interacting with promoter sequences, but there is also evidence of non‐canonical RNAa in eukaryotes. Emerging evidence suggests the presence of RNAa in insects. RNAa can be utilised as a tool for functional genomic studies in insects.
Sassan Asgari
wiley +1 more source