Results 111 to 120 of about 2,157,984 (211)

Engineered Yarrowia lipolytica inducing gene silencing confers control ability against gray mold in plants

Journal of Integrative Plant Biology, EarlyView.
Engineered the plant‐colonizing yeast Yarrowia lipolytica to produce and deliver double‐stranded RNAs targeting key genes of the gray mold fungus Botrytis cinerea produced a ‘living factory’ that continuously synthesizes and releases gene‐silencing molecules on plant surfaces, effectively suppressing the pathogen.
Mengjie Liu, Heng Shen, Jie Li, Mei Hao, Yelei Sun, Wenxing Liang   +5 more
wiley   +1 more source

Reovirus recombination is highly selective, and its profiles are primarily dictated by viral gene segment identity

Journal of Virology
Recombination facilitates the generation of defective viral genomes (DVGs), truncated derivatives of the parental genome that require a helper virus to replicate. Recombination mechanisms are poorly understood for viruses with double-stranded RNA (dsRNA)
Alejandra Flores, Andrew Routh, Ryan D. Xavier, Kristen M. Ogden   +3 more
doaj   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Viruses, Periodontitis, and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the viral involvement in periodontitis and its relevance for systemic diseases. The oral cavity acts as an active viral reservoir and dissemination platform, where virus–microbiome interactions may promote dysbiosis, periodontitis progression, and systemic inflammatory effects, while the ...
Kim Natalie Solte, Yvonne L. Hernandez‐Kapila, Henrik Dommisch   +2 more
wiley   +1 more source

microRNA‐mediated control of cell fate specification and patterning in Marchantia polymorpha

New Phytologist, EarlyView.
The gemma developmental program in Marchantia polymorpha is coordinated by MpMIR166‐mediated repression of MpC3HDZ and auxin homeostasis. Summary MicroRNAs (miRNAs) are small non‐coding RNA molecules essential for growth and development in eukaryotes. In plants, the master gene DICER‐LIKE 1 (DCL1) catalyzes the biogenesis of miRNAs by processing double‐
Adolfo Aguilar‐Cruz, Eduardo Flores‐Sandoval, Ye Xu, Yu Yu, Ximena Gutiérrez‐Ramos, Cristian Y. González‐Rangel, Omar Oltehua‐López, Ana E. Dorantes‐Acosta, Joshua T. Trujillo, Hirotaka Kato, Kimitsune Ishizaki, Rebecca A. Mosher, Liam Dolan, Xuemei Chen, Daniel Grimanelli, Jim Haseloff, John L. Bowman, Mario A. Arteaga‐Vazquez   +17 more
wiley   +1 more source

Applications and challenges of dsRNA-mediated RNAi in aquaculture

Water Biology and Security
Aquaculture plays a vital role in the global food supply but continues to face considerable challenges, including frequent disease outbreaks, low production efficiency, and environmental pollution.
Lihui Meng, Xintong Zhang, Min Zhou, Yi Wu, Jinyong Zhang   +4 more
doaj   +1 more source

Efficiency of RNAi‐based gene silencing in fungi: a meta‐analysis

New Phytologist, EarlyView.
Mechanistic interpretation of RNAi efficiency across fungal lifestyles and delivery strategies based on the present meta‐analysis. Summary RNA interference (RNAi) shows great potential to protect crops against fungal diseases, yet reported protection efficiencies vary greatly, and our understanding of the factors responsible for this variance remains ...
Patrick Barth, Jakob Drumm, Alexandra Erika Schmidt, Florian Hartig, Aline Koch   +4 more
wiley   +1 more source

PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration

Nature Communications
The innate immune sensor PKR for double-stranded RNA (dsRNA) is critical for antiviral defense, but its aberrant activation by cellular dsRNA is linked to various diseases.
Sadeem Ahmad, Tao Zou, Jihee Hwang, Linlin Zhao, Xi Wang, Anton Davydenko, Ilana Buchumenski, Patrick Zhuang, Alyssa R. Fishbein, Diego Capcha-Rodriguez, Aaron Orgel, Erez Y. Levanon, Sua Myong, James Chou, Matthew Meyerson, Sun Hur   +15 more
doaj   +1 more source

BcMFSR Is Required for Efficient Uptake of Exogenous dsRNA and Spray-Induced Gene Silencing in Botrytis cinerea. [PDF]

Mol Plant Pathol
Spray‐induced gene silencing (SIGS) uses exogenous dsRNA to silence pathogen genes and control grey mould disease. We identify BcMFSR, an MFS protein required for dsRNA uptake and SIGS efficacy in Botrytis cinerea. Loss of BcMFSR abolishes dsRNA internalization and disease suppression, revealing a novel role for MFS proteins.
Xu L, Yu Z, Du R, Ma H, Hu X, Wei R, Hu Q, Sheng C, Njoki WD, Chen P, Shi X, Tang C, Zhang H, Zhou S, Zhong H, Wang W, Umida I, Zhao H.   +17 more
europepmc   +2 more sources

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source