Results 21 to 30 of about 2,157,984 (211)

dsRNA-Seq: Identification of Viral Infection by Purifying and Sequencing dsRNA

Viruses, 2019
RNA viruses are a major source of emerging and re-emerging infectious diseases around the world. We developed a method to identify RNA viruses that is based on the fact that RNA viruses produce double-stranded RNA (dsRNA) while replicating. Purifying and
Carolyn J. Decker, Halley R. Steiner, Laura L. Hoon-Hanks, James H. Morrison, Kelsey C. Haist, Alex C. Stabell, Eric M. Poeschla, Thomas E. Morrison, Mark D. Stenglein, Sara L. Sawyer, Roy Parker   +10 more
doaj   +1 more source

Sequential packaging of RNA genomic segments during the assembly of Bluetongue virus. [PDF]

, 2014
Bluetongue virus (BTV), a member of the Orbivirus genus within the Reoviridae family, has a genome of 10 double-stranded RNA segments, with three distinct size classes.
Roy, Polly, Sung, Po-Yu, Po-yu Sung, Polly Roy   +3 more
core   +1 more source

TRBP and eIF6 homologue in Marsupenaeus japonicus play crucial roles in antiviral response.

PLoS ONE, 2012
Plants and invertebrates can suppress viral infection through RNA silencing, mediated by RNA-induced silencing complex (RISC). Trans-activation response RNA-binding protein (TRBP), consisting of three double-stranded RNA-binding domains, is a component ...
Shuai Wang, An-Jing Chen, Li-Jie Shi, Xiao-Fan Zhao, Jin-Xing Wang   +4 more
doaj   +1 more source

Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]

, 2003
Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, A., Boyd, A, Fazakerley, John K., Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, J. K. Fazakerley, Elliott, Richard M, Boyd, Amanda, H. Streitenfeld, Elliott, R.M., Streitenfeld, H., A. Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J K, Fazakerley, J.K., F. Weber, R. M. Elliott, Bridgen, A, Elliott, Richard Michael, Bridgen, Anne, A. Boyd   +25 more
core   +1 more source

Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy

Nature Communications, 2023
Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood.
Omar M. Hedaya, Kadiam C. Venkata Subbaiah, Feng Jiang, Li Huitong Xie, Jiangbin Wu, Eng-Soon Khor, Mingyi Zhu, David H. Mathews, Chris Proschel, Peng Yao   +9 more
doaj   +1 more source

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Cell Reports, 2021
Summary: Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A-to-I
Richard de Reuver, Evelien Dierick, Bartosz Wiernicki, Katrien Staes, Leen Seys, Ellen De Meester, Tuur Muyldermans, Alexander Botzki, Bart N. Lambrecht, Filip Van Nieuwerburgh, Peter Vandenabeele, Jonathan Maelfait   +11 more
doaj   +1 more source

EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice [PDF]

, 2005
Background: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer. With the available treatments, survival does not exceed 12–14 mo from the time of diagnosis.
Levitzki, Alexander, Alexander Levitzki (32255), Shir Alexei, Levitzki Alexander, Manfred Ogris, Ernst Wagner (60760), Wagner, Ernst, Ernst Wagner, Ogris Manfred, Alexander Levitzki, Ogris, Manfred, Manfred Ogris (60759), Alexei Shir (60758), Shir, Alexei, Wagner Ernst, Alexei Shir   +15 more
core   +2 more sources

RNA Interference Is Enhanced by Knockdown of Double-Stranded RNases in the Yellow Fever Mosquito Aedes aegypti

Insects, 2020
RNA interference (RNAi) techniques are being developed for a range of pest insect control technologies, including the sterile insect technique (SIT) and double-stranded RNA (dsRNA)-based insecticides. In SIT applications, where >99% of the released males
David Giesbrecht, Daniel Heschuk, Ian Wiens, David Boguski, Parker LaChance, Steve Whyard   +5 more
doaj   +1 more source

Advances in the Development of Microbial Double-Stranded RNA Production Systems for Application of RNA Interference in Agricultural Pest Control

Frontiers in Bioengineering and Biotechnology, 2021
RNA interference (RNAi) is a valuable and revolutionary technology that has been widely applied in medicine and agriculture. The application of RNAi in various industries requires large amounts of low-cost double-stranded RNA (dsRNA).
Ruobing Guan, Dongdong Chu, Xinyi Han, Xuexia Miao, Haichao Li, Haichao Li   +5 more
doaj   +1 more source

RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease. [PDF]

, 2010
Ribonucleases play important roles in the RNA interference (RNAi) pathway. The Dicer endonuclease converts double-stranded (ds)RNA into small interfering (si)RNA and the Slicer endonuclease, as a component of the RNA induced silencing complex (RISC ...
Louise E. Kemp, Kawahara, Taemi, Horn, David, Horn, David; id_orcid, Kemp, Louise E, Sam Alsford, Taemi Kawahara, Alsford, Sam, Kemp, Louise E., David Horn   +9 more
core   +1 more source