Results 31 to 40 of about 2,157,984 (211)

A dsRNA virus with filamentous viral particles

Nature Communications, 2017
Viruses with double-stranded RNA (dsRNA) genomes form typically isometric particles or are capsid-less. Here, the authors identify a mycovirus with an eight-segmented dsRNA genome that forms exceptionally long filamentous particles and could represent an
Hengxia Jia, Kaili Dong, Lingling Zhou, Guoping Wang, Ni Hong, Daohong Jiang, Wenxing Xu   +6 more
doaj   +1 more source

Use of microalgae Chlamydomonas reinhardtii for production of double-stranded RNA against shrimp virus

Aquaculture Reports, 2016
RNA interference has been proposed to be a promising tool for combating shrimp viruses. Antiviral double-stranded (ds)RNA has been mostly produced in Escherichia coli-expression system because of its high efficiency and inexpensive operations.
Parinyachat Somchai, Sarocha Jitrakorn, Siripong Thitamadee, Metha Meetam, Vanvimon Saksmerprome   +4 more
doaj   +1 more source

Genome-Wide CRISPR-Cas9 Screen Reveals the Importance of the Heparan Sulfate Pathway and the Conserved Oligomeric Golgi Complex for Synthetic Double-Stranded RNA Uptake and Sindbis Virus Infection

mSphere, 2020
Double-stranded RNA (dsRNA) is the hallmark of many viral infections. dsRNA is produced either by RNA viruses during replication or by DNA viruses upon convergent transcription.
Olivier Petitjean, Erika Girardi, Richard Patryk Ngondo, Vladimir Lupashin, Sébastien Pfeffer   +4 more
doaj   +1 more source

Distinct pathways for export of silencing RNA in Caenorhabditis elegans systemic RNAi

iScience, 2023
Summary: Dietary supplied double-stranded RNA (dsRNA) can trigger RNA interference (RNAi) systemically in some animals, including the nematode Caenorhabditis elegans.
Keita Yoshida, Yuji Suehiro, Katsufumi Dejima, Sawako Yoshina, Shohei Mitani   +4 more
doaj   +1 more source

Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression

Life Science Alliance
The accumulation of mitochondrial double-stranded RNA (mt-dsRNA) in cancer cells depends on cell proliferation status. Mt-dsRNA is more abundant in patient lung adenocarcinoma compared with healthy tissue.
Vanessa Xavier, Silvia Martinelli, Ryan Corbyn, Rachel Pennie, Kai Rakovic, Ian R Powley, Leah Officer-Jones, Vincenzo Ruscica, Alison Galloway, Leo M Carlin, Victoria H Cowling, John Le Quesne, Jean-Claude Martinou, Thomas MacVicar   +13 more
doaj   +1 more source

Double-Stranded RNA Is Detected by Immunofluorescence Analysis in RNA and DNA Virus Infections, Including Those by Negative-Stranded RNA Viruses. [PDF]

, 2015
Early biochemical studies of viral replication suggested that most viruses produce double-stranded RNA (dsRNA), which is essential for the induction of the host immune response.
Z Liang (7928936), HL Lipton (7928939), KN Son (7928933)   +2 more
core   +6 more sources

The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells [PDF]

, 2008
The NS3 protein of the tenuivirus rice hoja blanca virus (RHBV) has previously been shown to represent the viral RNA interference (RNAi) suppressor and is active in both plant and insect cells by binding short interfering RNAs (siRNAs) in vitro.
Hemmes, J.C., Schnettler, E., Goldbach, R.W., Prins, M.W.   +3 more
core   +1 more source

Removal of dsRNA byproducts using affinity chromatography

Molecular Therapy: Nucleic Acids
Double-stranded RNA (dsRNA) molecules are immunogenic byproducts of in vitro transcription of single-stranded RNA (ssRNA). Removal of dsRNA from ssRNA is difficult because the byproducts have similar sizes, sequences, and charges to the desired ssRNA ...
Nathaniel E. Clark, Mateusz Kozarski, Sinem Demirel Asci, Jurgen Van den Heuvel, Matt R. Schraut, Roger A. Winters, Kelley Kearns, Thomas C. Scanlon, Senne Dillen   +8 more
doaj   +1 more source

Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon [PDF]

, 2002
Production of alpha/beta interferons (IFN-α/β) in response to viral infection is one of the main defense mechanisms of the innate immune system. Many viruses therefore encode factors that subvert the IFN system to enhance their virulence.
Richard E. Randall, Randall, Richard E, Friedemann Weber, Fazakerley, John K., Nina Kessler, Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, Elliott, Richard M, Randall, R.E., Kessler, N, Elliott, R.M., Streitenfeld, H., Richard M. Elliott, Kessler, N., Anne Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J.K., Kessler, Nina, Hein Streitenfeld, Bridgen, A, Elliott, Richard Michael, Fazakerley, JK, John K. Fazakerley, Bridgen, Anne, Randall, Richard Edward   +29 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source