Results 81 to 90 of about 1,209,458 (341)

MicroRNA (miRNA) PROFILING IN PROSTATE CANCER CARCINOGENESIS: EXPLORATORY RESEARCH

Jurnal Kedokteran dan Kesehatan
Future research will continue to be carried out in terms of looking for molecular markers involved in the early processes of carcinogenesis, metastasis and therapeutic targets in prostate cancer patients.
Maria Ulfa, Krisna Murti
doaj   +1 more source

The Mysterious Ways of ErbB2/HER2 Trafficking

Membranes, 2014
The EGFR- or ErbB-family of receptor tyrosine kinases consists of EGFR/ErbB1, ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4. Receptor activation and downstream signaling are generally initiated upon ligand-induced receptor homo- or heterodimerization at the ...
Vibeke Bertelsen, Espen Stang
doaj   +1 more source

LPS Down-Regulates Specificity Protein 1 Activity by Activating NF-κB Pathway in Endotoxemic Mice. [PDF]

PLoS ONE, 2015
Specificity protein (Sp) 1 mediates the transcription of a large number of constitutive genes encoding physiological mediators. NF-κB mediates the expression of hundreds of inducible genes encoding pathological mediators.
Xiaobing Ye, Hong Liu, Yong-Sheng Gong, Shu Fang Liu   +3 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells [PDF]

, 2009
Enhanced motility of cancer cells by remodelling of the actin cytoskeleton is crucial in the process of cancer cell invasion and metastasis. Although several studies propose a tumor suppressor role for the actin bundling protein myopodin, it was also ...
Bracke, Marc, Bruyneel, Erik, De Corte, Veerle, De Ganck, Ariane, Gettemans, Jan, Vandekerckhove, Joël   +5 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Interleukin-1 as an injury signal mobilizes retinyl esters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase. [PDF]

PLoS ONE, 2011
Retinoids are mostly stored as retinyl esters in hepatic stellate cells (HSCs) through esterification of retinol and fatty acid, catalyzed by lecithin-retinol acyltransferase (LRAT). This study is designated to address how retinyl esters are mobilized in
Yujiro Kida, Zanxian Xia, Sujun Zheng, Nicholas M Mordwinkin, Stan G Louie, Song Guo Zheng, Min Feng, Hongbo Shi, Zhongping Duan, Yuan-Ping Han   +9 more
doaj   +1 more source

SoxRS Down-Regulation ofrobTranscription [PDF]

Journal of Bacteriology, 2002
ABSTRACTRob is regarded as a constitutively expressed protein, although little is known about howrobgene is regulated. We show here by reverse transcription-PCR that the transcriptional levels ofrobare strongly down-regulated in response to the superoxide-generating agent paraquat (PQ).
Manuel Manchado, Carmen Pueyo, Carmen Michán   +2 more
openaire   +3 more sources

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Down‐Regulation of gp96 by Orientia tsutsugamushi [PDF]

Microbiology and Immunology, 2004
Abstractgp96 plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, and cross‐priming, and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules.
Seung Yong Seong, Seung Yong Seong, Nam Hyuk Cho, Cheol Young Choi   +3 more
openaire   +3 more sources