Results 1 to 10 of about 462,684 (373)

Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia [PDF]

Mediators of Inflammation, 2015
It has previously been demonstrated that ischemic stroke activates autophagy pathways; however, the mechanism remains unclear. The aim of this study is to further investigate the role that autophagy plays in cerebral ischemia.
Yang Yang, Keqiang Gao, Zhiying Hu, Weiyun Li, Henry Davies, Shucai Ling, John A. Rudd, Marong Fang   +7 more
doaj   +7 more sources

Downregulation of MEG3 and upregulation of EZH2 cooperatively promote neuroblastoma progression [PDF]

Journal of Cellular and Molecular Medicine, 2022
Neuroblastoma (NB), an embryonic tumour originating from sympathetic crest cells, is the most common extracranial solid tumour type in children with poor overall prognosis.
M. Ye, Runnan Gao, Shiyu Chen, Meng Wei, Jing Wang, Bowen Zhang, Suwen Wu, Yuexin Xu, Peixuan Wu, X. Chen, Jing Ma, Duan Ma, K. Dong   +12 more
semanticscholar   +3 more sources

Inhibition of Proliferation and Induction of Autophagy by Atorvastatin in PC3 Prostate Cancer Cells Correlate with Downregulation of Bcl2 and Upregulation of miR-182 and p21

PLoS ONE, 2013
The epidemiologic association between statin use and decreased risk of advanced prostate cancer suggests that statins may inhibit prostate cancer development and/or progression.
Xinjian Peng, Wenping Li, Liang Yuan, Rajendra G. Mehta, Levy Kopelovich, David L. McCormick   +5 more
openalex   +3 more sources

Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice

Experimental and Molecular Medicine, 2023
Mounting evidence suggests that probiotics are beneficial for treating Alzheimer’s disease (AD). However, the mechanisms by which specific probiotics modify AD pathophysiology are not clearly understood.
Hyejin Kwon, Eun-Hwa Lee, So-Young Park, Jin-Young Park, Jin-Hwan Hong, Eun-Kyung Kim, Tae-Seop Shin, Yoon-Keun Kim, Pyung-Lim Han   +8 more
doaj   +2 more sources

Simultaneous downregulation of miR-21 and upregulation of miR-7 has anti-tumor efficacy [PDF]

Scientific Reports, 2020
Dysregulation of miRNA expression has been implicated in cancer. Numerous strategies have been explored to modulate miR but sub-optimal delivery and inability to concurrently target multiple pathways involved in tumor progression have limited their ...
Deepak Bhere, Nahid Arghiani, Esther Revai Lechtich, Yizheng Yao, Sarah Alsaab, Fengfeng Bei, Maryam M. Matin, Khalid Shah   +7 more
doaj   +2 more sources

Temporal dynamics of gene and protein signatures following volumetric muscle loss [PDF]

Frontiers in Cell and Developmental Biology
IntroductionVolumetric muscle loss (VML) is characterized by permanent tissue impairment resulting from critically-sized muscle loss. We performed time-series transcriptomic and proteomic analyses to reveal key mediators of irreversible pathological ...
Ishita Jain, Ishita Jain, Ishita Jain, Beu P. Oropeza, Beu P. Oropeza, Beu P. Oropeza, Caroline Hu, Gladys Chiang, Sree Aravindan, Renato Reyes, Daniel Yuhang Li, Paul Cheng, Paul Cheng, Ngan F. Huang, Ngan F. Huang, Ngan F. Huang, Ngan F. Huang, Ngan F. Huang   +17 more
doaj   +2 more sources

TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation [PDF]

Neuropsychopharmacology, 2018
Giselli Scaini, Tatiana Barichello, Gabriel R. Fries, Elizabeth A. Kennon, Taylor Andrews, Bobby Nix, Giovana Zunta‐Soares, Samira S. Valvassori, Jair C. Soares, João Quevedo   +9 more
openalex   +2 more sources

Machine learning on thyroid disease: a review

Frontiers in Bioscience-Landmark, 2022
This study reviews the recent progress of machine learning for the early diagnosis of thyroid disease. Based on the results of this review, different machine learning methods would be appropriate for different types of data for the early diagnosis of ...
Kwang-Sig Lee, Hyuntae Park
doaj   +1 more source

Emotion Downregulation Targets Interoceptive Brain Regions While Emotion Upregulation Targets Other Affective Brain Regions

Journal of Neuroscience, 2022
Researchers generally agree that when upregulating and downregulating emotion, control regions in the prefrontal cortex turn up or down activity in affect-generating brain areas.
Jungwon Min, K. Nashiro, H. Yoo, C. Cho, P. Nasseri, S. Bachman, S. Porat, J. Thayer, Catie Chang, Taeho Lee, M. Mather   +10 more
semanticscholar   +1 more source

Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5

Cell Death and Disease, 2022
Ubiquitin-specific protease 1 (USP1) is a deubiquitinase involved in DNA damage repair by modulating the ubiquitination of major regulators, such as PCNA and FANCD2.
S. Woo, Seok Kim, S. Seo, Shin Kim, Jong-Wook Park, Gyeonghwa Kim, Yu-Ra Choi, K. Hur, T. Kwon   +8 more
semanticscholar   +1 more source