Results 31 to 40 of about 453,301 (335)

PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression [PDF]

, 2015
To overcome cancer cells resistance to pharmacological therapy, the development of new therapeutic approaches becomes urgent. For this purpose, the use of poly(ADP-ribose) polymerase (PARP) inhibitors in combination with other cytotoxic agents could ...
CAIAFA, Paola, CALABRESE, ROBERTA, CICCARONE, FABIO, Daniela Trisciuoglio, Donatella Del Bufalo, GUASTAFIERRO, Tiziana, MARIANO, GERMANO, REALE, Anna, RICCIARDI, Maria Rosaria, TAFURI, Agostino, VALENTINI, ELISABETTA, ZAMPIERI, Michele   +11 more
core   +2 more sources

MicroRNA 3928 Suppresses Glioblastoma through Downregulation of Several Oncogenes and Upregulation of p53

International Journal of Molecular Sciences, 2022
Glioblastoma (GBM) is the most frequent and lethal primary malignant brain tumor. Despite decades of research, therapeutic advances that significantly prolong life are non-existent. In recent years, microRNAs (miRNAs) have been a focus of study in the pathobiology of cancer because of their ability to simultaneously regulate multiple genes.
Elizabeth Q. X. Mulcahy, Ying Zhang, Rossymar R. Colόn, Shelby R. Cain, Myron K. Gibert, Collin J. Dube, Markus Hafner, Roger Abounader   +7 more
openaire   +2 more sources

HEATR1 Deficiency Promotes Chemoresistance via Upregulating ZNF185 and Downregulating SMAD4 in Pancreatic Cancer [PDF]

Journal of Oncology, 2020
Objective. To discover the correlated gene with HEATR1 in regulating chemoresistance of gemcitabine.Methods. Gene chip analysis was performed to find out differential genes between HEATR1-KD and control groups. The top 20 genes were subjected to high-content screening, and functional assay was implemented.
Yuan Fang, Xu Han, Jianang Li, Tiantao Kuang, Wenhui Lou   +4 more
openaire   +2 more sources

Gene Dosage- and Age-Dependent Differential Transcriptomic Changes in the Prefrontal Cortex of Shank2-Mutant Mice

Frontiers in Molecular Neuroscience, 2021
Shank2 is an abundant postsynaptic scaffolding protein that is known to regulate excitatory synapse assembly and synaptic transmission and has been implicated in various neurodevelopmental disorders, including autism spectrum disorders (ASD).
Seungjoon Lee, Hyojin Kang, Hwajin Jung, Eunjoon Kim, Eunjoon Kim, Eunee Lee, Eunee Lee   +6 more
doaj   +1 more source

Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. [PDF]

, 2011
Glial cell line-derived neurotrophic factor (GDNF) is an essential growth factor for the survival and maintenance of the midbrain dopaminergic (DA-ergic) neurons.
Ahmadiantehrani, S, Barak, S, Kharazia, V, Ron, D   +3 more
core   +3 more sources

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L., Comings D. E., Delbrück M., Rastan S., Rosspopoff O.   +4 more
core   +1 more source

Differential expression of microRNAs in mouse liver under aberrant energy metabolic status[S]

Journal of Lipid Research, 2009
Despite years of effort, exact pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains obscure. To gain an insight into the regulatory roles of microRNAs (miRNAs) in aberrant energy metabolic status and pathogenesis of NAFLD, we analyzed the ...
Shengjie Li, Xi Chen, Hongjie Zhang, Xiangying Liang, Yang Xiang, Chaohui Yu, Ke Zen, Youming Li, Chen-Yu Zhang   +8 more
doaj   +1 more source

JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma. [PDF]

, 2016
A prominent mechanism of acquired resistance to BRAF inhibitors in BRAF (V600) -mutant melanoma is associated with the upregulation of receptor tyrosine kinases.
Atefi, Mohammad, Friedman, Michael, Graeber, Thomas G, Hong, Aayoung, Hugo, Willy, Komisopoulou, Evangelia, Kong, Xiangju, Le, Allison, Li, Richard, Lo, Roger S, Lomova, Anastasia, Moriceau, Gatien, Ribas, Antoni, Shi, Hubing, Song, Chunying, Ten Hoeve, Johanna, Titz, Bjoern   +16 more
core   +3 more sources

Altitudinal Variation of Metabolites, Mineral Elements and Antioxidant Activities of Rhodiola crenulata (Hook.f. & Thomson) H.Ohba

Molecules, 2021
Rhodiolacrenulata (Hook.f. & Thomson) H.Ohba is an alpine medicinal plant that can survive in extreme high altitude environments. However, its changes to extreme high altitude are not yet clear.
Tingting Dong, Yueqi Sha, Hairong Liu, Liwei Sun   +3 more
doaj   +1 more source

Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]

, 2019
Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An, Anang, Dornatien Chuo, Baatout, Sarah, Decrock, Elke, Leybaert, Luc, Monsieurs, Pieter, Mysara, Mohamed, Ramadan, Raghda, Vromans, Els   +8 more
core   +2 more sources