Results 31 to 40 of about 462,684 (373)

Upregulated wnt-11 and mir-21 expression trigger epithelial mesenchymal transition in aggressive prostate cancer cells [PDF]

, 2020
Prostate cancer (PCa) is the second-leading cause of cancer-related death among men. microRNAs have been identified as having potential roles in tumorigenesis.
Arisan, E.D., Arisan, E.D., Freitas, I.L., Freitas, I.L., Keskin, B., Keskin, B., Kothari, A., Kothari, A., Radzali, S., Radzali, S., Rencuzogullari, O., Rencuzogullari, O., Uysal-Onganer, P., Uysal-Onganer, P., Warford, A., Warford, A.   +15 more
core   +1 more source

Akt Blockade Downregulates Collagen and Upregulates MMP1 in Human Dermal Fibroblasts [PDF]

Journal of Investigative Dermatology, 2008
Acutely transforming retrovirus AKT8 in rodent T-cell lymphoma (Akt) is a serine/threonine kinase that plays important roles in survival, cell-cycle progression, and cell proliferation, and has recently been implicated in collagen regulation. The aim of this study was to determine the role of Akt in collagen deposition by normal dermal fibroblasts, and
Jaspreet Pannu, Edwin A. Smith, Robin C. Muise-Helmericks, Andreea M. Bujor, Shizhong Bu, Maria Trojanowska   +5 more
openaire   +3 more sources

Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1

iScience, 2023
Cisplatin resistance remains a major obstacle limiting the effectiveness of chemotherapy in cervical cancer. However, the underlying mechanism of cisplatin resistance is still unclear. In this study, we demonstrate that vacuolar protein sorting 13 homolog C (VPS13C) deficiency promotes cisplatin resistance in cervical cancer.
Xiangyu Tan, Xueqian Wang, Xueyao Liao, Xin Wang, Zhichao Jiang, Wenjia Liang, Chen Cao, Danni Gong, Zheng Hu, Xun Tian   +9 more
openaire   +3 more sources

C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro [PDF]

, 2015
Subjects carrying the T2238C ANP gene variant have a higher risk to suffer a stroke or myocardial infarction. The mechanisms through which T2238C/αANP exerts detrimental vascular effects need to be fully clarified.
Bianchi, Franca, Cotugno, Maria, DI CASTRO, SARA, FRATI, GIACOMO, MARCHITTI, Simona, RUBATTU, Speranza Donatella, SCARPINO, Stefania, SCIARRETTA, SEBASTIANO, Stanzione, Rosita, VOLPE, Massimo   +9 more
core   +1 more source

Upregulation of Parkin Accelerates Osteoblastic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells and Bone Regeneration by Enhancing Autophagy and β-Catenin Signaling

Frontiers in Cell and Developmental Biology, 2020
Osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) plays a key role in bone formation. Parkin, an E3 ubiquitin ligase, related to Parkinson’s disease and aging. Previous studies have indicated that Parkinson’s disease have a
Wei Zhang, Wei Zhang, Weiduo Hou, Weiduo Hou, Mo Chen, Erman Chen, Erman Chen, Deting Xue, Deting Xue, Chenyi Ye, Chenyi Ye, Weixu Li, Weixu Li, Zhijun Pan, Zhijun Pan   +14 more
doaj   +1 more source

Microarray-based screening of differentially expressed genes of E. coli O157:H7 Sakai during preharvest survival on butterhead lettuce [PDF]

, 2016
Numerous outbreaks of Escherichia coli O157:H7 have been linked to the consumption of leafy vegetables. However, up to the present, little has been known about E.
Cottyn, Bart, Heyndrickx, Marc, Holden, Nicola, Maes, Martine, Uyttendaele, Mieke, Van der Linden, Inge, Vlaemynck, Geertrui   +6 more
core   +3 more sources

Upregulation of GLUT4 and PI3K, and downregulation of GSK3 mediate the anti‑hyperglycemic effects of proanthocyanidins

Medicine International, 2022
Diabetes mellitus is the most common chronic metabolic disorder worldwide. The present study was designed to investigate the potential role of cinnamon bark extract oligomeric proanthocyanidins (OPCs) in controlling streptozotocin (STZ)-induced hyperglycemia and to clarify the underlying molecular mechanisms underlying its effects. For this purpose, 60
Nahla E. El‐Ashmawy, Eman M. Khedr, Nehal Alfeky, Amera O. Ibrahim   +3 more
openalex   +4 more sources

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP

Molecules, 2018
Maritoclax, an active constituent isolated from marine bacteria, has been known to induce Mcl-1 downregulation through proteasomal degradation. In this study, we investigated the sensitizing effect of maritoclax on tumor necrosis factor-related apoptosis-
Mi-Yeon Jeon, Kyoung-jin Min, Seon Min Woo, Seung Un Seo, Yung Hyun Choi, Sang Hyun Kim, Dong Eun Kim, Tae-Jin Lee, Shin Kim, Jong-Wook Park, Taeg Kyu Kwon   +10 more
doaj   +1 more source

Chlorogenic Acid Ameliorates Liver Function in Association with Bax Downregulation, P53 Downregulation and Bcl-2 Upregulation in Diabetic Wistar Rat [PDF]

BIO Web of Conferences, 2022
Hyperglycemia in Diabetes mellitus (DM) induces oxidative stress and mitochondrial disruptions in the liver, thereby triggering apoptosis through Bcl-2 family signaling. Excessive apoptosis leads to liver dysfunction.
Setyaningsih Mayang, Meliala Andreanyta, Cempaka Rita, Arfian Nur   +3 more
doaj   +1 more source

LncRNAMORT is upregulated in myocardial infarction and promotes the apoptosis of cardiomyocyte by downregulating miR-93 [PDF]

BMC Cardiovascular Disorders, 2020
Abstract Background Myocardial infarction (MI) affects the expression of a large number of lncRNAs, while the functions of those dysregulated lncRNAs are mostly unclear. Materials and methods Expression of MORT and miR-93 in hearth tissues and plasma of both MI mice and Sham mice and both MI patients and healthy controls was detected by RT-qPCR ...
Jing Lv, Yi Zhu, Shanglong Yao
openaire   +4 more sources