Results 41 to 50 of about 462,684 (373)

JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma. [PDF]

, 2016
A prominent mechanism of acquired resistance to BRAF inhibitors in BRAF (V600) -mutant melanoma is associated with the upregulation of receptor tyrosine kinases.
Atefi, Mohammad, Friedman, Michael, Graeber, Thomas G, Hong, Aayoung, Hugo, Willy, Komisopoulou, Evangelia, Kong, Xiangju, Le, Allison, Li, Richard, Lo, Roger S, Lomova, Anastasia, Moriceau, Gatien, Ribas, Antoni, Shi, Hubing, Song, Chunying, Ten Hoeve, Johanna, Titz, Bjoern   +16 more
core   +3 more sources

Upregulation of ADAMTS‑7 and downregulation of COMP are associated with spontaneous abortion

Molecular Medicine Reports, 2019
A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS‑7) has been revealed to serve an important role in inflammation‑associated diseases. However, the role of ADAMTS‑7 in spontaneous abortion (SA) remains unclear. In the present study, human and mouse decidual tissues were used to detect the expression of ADAMTS‑7 and cartilage ...
Na‑Na Yan, Yang Mu, Jing Yang, Dan‑Ni Zhou, Jin‑Li Ding   +4 more
openaire   +4 more sources

MicroRNAs in lung cancer [PDF]

, 2017
Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this ...
An, Baltimore, Belinsky, Brennan, Chen, De Flora, De Flora, Dong, Duan, Gomez, Hao, Harris, Hasegawa, Haugen, Hu, Inoue, Jemal, Jia, Lam, Li, Liu, Nakanishi, Neilson, O'Driscoll, Pan, Peiper, Ren, Schmeck, Schrump, Sensinger, Shah, Slack, Speiser, Stampfli, Wang, Wang, Yoshida, You, Zhang, Zhang, Zienolddiny   +40 more
core   +1 more source

Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients [PDF]

Translational Psychiatry, 2012
Increasing evidence suggests that epigenetic dysfunction may account for the alteration of gene transcription present in neuropsychiatric disorders such as schizophrenia (SZ), bipolar disorder (BP) and autism. Here, we studied the expression of the ten-eleven translocation (TET) gene family and activation-induced deaminase/apolipoprotein B mRNA-editing
Erbo Dong, Ying Chen, John M. Davis, David P. Gavin   +3 more
openaire   +3 more sources

Prostaglandin F2 and EP2 Agonists Exert Different Effects on 3D 3T3-L1 Spheroids during Their Culture Phase

Biomedicines, 2021
To elucidate the effects of switching a PGF2α agonist, bimatoprost acid (BIM-A), to an EP2 agonist (Omidenepag—OMD; butaprost—Buta) or reversing the switching on adipose tissue, two-dimensional (2D) and three-dimensional (3D) cultures of 3T3-L1 cells ...
Yosuke Ida, Masato Furuhashi, Megumi Watanabe, Araya Umetsu, Fumihito Hikage, Hiroshi Ohguro   +5 more
doaj   +1 more source

Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family

International Journal of Molecular Medicine, 2016
Colorectal cancer (CRC) is among the most frequent causes of cancer-related deaths worldwide. Thus, there is a need for the development of new therapeutic approaches for the treatment of CRC.
M. Suliman, Zhenxing Zhang, Heya Na, Ailton L.L. Ribeiro, Yu Zhang, B. Niang, Abdu Salim Hamid, Hua Zhang, Lijie Xu, Y. Zuo   +9 more
semanticscholar   +1 more source

Plasma microRNA levels following resection of metastatic melanoma [PDF]

, 2017
Melanoma remains the leading cause of skin cancer–related deaths. Surgical resection and adjuvant therapies can result in disease-free intervals for stage III and stage IV disease; however, recurrence is common.
Abrams, Zachary B, Agnese, Doreen, Carson III, William E, Fadda, Paolo, Howard, J. Harrison, Jacob, Naduparambil, Latchana, Nicholas, Markowitz, Joseph, Payne, Philip, Regan, Kelly, Terando, Alicia   +10 more
core   +3 more sources

Gene Dosage- and Age-Dependent Differential Transcriptomic Changes in the Prefrontal Cortex of Shank2-Mutant Mice

Frontiers in Molecular Neuroscience, 2021
Shank2 is an abundant postsynaptic scaffolding protein that is known to regulate excitatory synapse assembly and synaptic transmission and has been implicated in various neurodevelopmental disorders, including autism spectrum disorders (ASD).
Seungjoon Lee, Hyojin Kang, Hwajin Jung, Eunjoon Kim, Eunjoon Kim, Eunee Lee, Eunee Lee   +6 more
doaj   +1 more source

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Mutzel, V., Schulz, E.
core   +1 more source

Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]

, 2019
Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An, Anang, Dornatien Chuo, Baatout, Sarah, Decrock, Elke, Leybaert, Luc, Monsieurs, Pieter, Mysara, Mohamed, Ramadan, Raghda, Vromans, Els   +8 more
core   +2 more sources