Results 71 to 80 of about 462,684 (373)

Platelet-rich plasma combined with isometric quadriceps contraction regulates autophagy in chondrocytes via the PI3K/AKT/mTOR pathway to promote cartilage repair in knee osteoarthritis

Regenerative Therapy
Background: This study investigated the molecular mechanism by which the combination of platelet-rich plasma (PRP) and isometric contraction of the quadriceps (ICQ) intervention regulates autophagy in chondrocytes to prevent and treat knee osteoarthritis
Liang Cheng, Shuwan Chang, Yajun Tan, Benxiang He   +3 more
doaj   +1 more source

MicroRNAs and Their Therapeutic Potential for Human Diseases: MiR-133a and Bronchial Smooth Muscle Hyperresponsiveness in Asthma

Journal of Pharmacological Sciences, 2010
.: MicroRNAs (miRNAs) play important roles in normal and diseased cell functions. The small-GTPase RhoA is one of the key proteins of bronchial smooth muscle (BSM) contraction, and an upregulation of RhoA has been demonstrated in BSMs of experimental ...
Yoshihiko Chiba, Miwa Misawa
doaj   +1 more source

Transcriptome Analysis of the Cerebellum of Mice Fed a Manganese-Deficient Diet

Frontiers in Genetics, 2020
Manganese (Mn), primarily acquired through diet, is required for brain function and development. Epidemiological studies have found an association between both low and high levels of Mn and impaired neurodevelopment in children.
Young Ah Seo, Eun-Kyung Choi, Luisa Aring, Molly Paschall, Shigeki Iwase   +4 more
doaj   +1 more source

CTBP1‑AS upregulation is associated with polycystic ovary syndrome and can be effectively downregulated by cryptotanshinone

Molecular Medicine Reports, 2022
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies and primarily presents with hyperandrogenism. Although environmental factors and genetic factors are thought to be the major reason, there still exists a lot of questions need to be answered. High expression of C‑terminal‑binding protein 1 antisense (CTBP1‑AS) was identified as
Wen, Mingxiao, Dou, Xiaoqing, Zhang, Shuzhen, Wang, Bin, Xu, Jiangyan, Zhang, Wenchao, Wang, Feifei   +6 more
openaire   +2 more sources

Differential conserted activity induced regulation of Nogo receptors (1-3), LOTUS and Nogo mRNA in mouse brain. [PDF]

PLoS ONE, 2013
Nogo Receptor 1 (NgR1) mRNA is downregulated in hippocampal and cortical regions by increased neuronal activity such as a kainic acid challenge or by exposing rats to running wheels.
Tobias E Karlsson, Josefin Koczy, Stefan Brené, Lars Olson, Anna Josephson   +4 more
doaj   +1 more source

MicroRNA-29a-3p Downregulation Causes Gab1 Upregulation to Promote Glioma Cell Proliferation

Cellular Physiology and Biochemistry, 2018
Background/Aims: Glioma causes significant human mortalities annually. Molecularly-targeted therapy is a focus of glioma research. Methods: Grb2-associated binding 1 (Gab1) expression and microRNA-29a-3p (“miR-29a-3p”) expression in human glioma cells ...
N. Shao, Dong-xing Wang, Yin Wang, Ya Li, Zhi-qing Zhang, Qin Jiang, Weifeng Luo, C. Cao   +7 more
semanticscholar   +1 more source

The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]

, 2017
Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core   +2 more sources

Common bean resistance to Xanthomonas is associated with upregulation of the salicylic acid pathway and downregulation of photosynthesis. [PDF]

BMC Genomics, 2020
Abstract Background: Common bacterial blight (CBB) caused by Xanthomonas phaseoli pv. phaseoli and Xanthomonas citri pv. fuscans is one of the major threats to common bean crops (Phaseolus vulgaris L.). Resistance to CBB is particularly complex as 26 quantitative resistance loci to CBB have been described so far. To date, transcriptomic studies
Foucher, Justine, Ruh, Mylène, Preveaux, Anne, Carrere, Sébastien, Pelletier, Sandra, Briand, Martial, Serre, Rémy-Félix, Jacques, Marie-Agnès, Chen, Nicolas W. G.   +8 more
openaire   +6 more sources

Genetic alterations of CDX1, CYLD and CDKN2B genes in CRC

Journal of Current Oncology and Medical Sciences, 2021
Introduction: Colorectal cancer (CRC) is the third most frequent type of cancer in the world. In this explanation, genetic variation is associated in all cancers, particularly CRC, and modifications of numerous genes, such as CDX1, CYLD, and CDKN2B, are ...
Seyed Mohammad Taghi Hamidian, Rezvan Azadi, Pooya Rostami , Farnaz Azar Shabe , Zeynab Khazaee Kohparc   +4 more
doaj  

Long noncoding RNA HOTTIP promotes the metastatic potential of ovarian cancer through the regulation of the miR‐615‐3p/SMARCE1 pathway

Kaohsiung Journal of Medical Sciences, 2020
Upregulation of lncRNA HOXA transcript at the distal tip (HOTTIP) plays important roles in cancer progression. Nevertheless, its functions in the growth and metastasis of ovarian carcinoma are unknown.
Hong Wu, Hong‐Yan Wei, Qian‐Qian Chen   +2 more
doaj   +1 more source