Results 21 to 30 of about 95,266 (202)
Molecules, 2021 Zika virus (ZIKV) represents a re-emerging threat to global health due to its association with congenital birth defects. ZIKV NS2B-NS3 protease is crucial for virus replication by cleaving viral polyprotein at various junctions to release viral proteins ...
Teow Chong Teoh +3 more
doaj +1 more source
Investigation of a combination therapy approach for the treatment of melioidosis
Frontiers in Microbiology, 2022 The efficacy of finafloxacin as a component of a layered defense treatment regimen was determined in vitro and in vivo against an infection with Burkholderia pseudomallei.
Kay B. Barnes +9 more
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Frontiers in Veterinary Science, 2020 The beef cattle rumen is a heterogenous microbial ecosystem that is necessary for the host to digest food and support growth. The importance of the rumen microbiota (RM) is also widely recognized for its critical roles in metabolism and immunity.
Fengmei Chen +8 more
doaj +1 more source
Antioxidants, 2022 Excess alcohol consumption is a potential risk factor for cardiovascular diseases and is linked to accelerated aging. Drug discovery to reduce toxic cellular events of alcohol is required.
Xuanchen Li +4 more
doaj +1 more source
Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]
J Cell Biochem (2021) 1-8, 2020 The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv +1 more source
Efficacy of Oral Doxycycline versus Intravenous Doxycycline for the Treatment of Uncomplicated Scrub Typhus in Children: A Prospective Interventional Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Orientia tsutsugamushi causes acute febrile illness known as scrub typhus, which is spread by the bite of the trombiculid mite. Doxycycline is the first-line treatment for clinically diagnosed cases of scrub typhus. If not diagnosed and
BSK CHANDRA DEVE VARMA +3 more
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PLoS ONE, 2014 BackgroundDetecting a new effective and hypotoxic anticancer drug is an emerging new strategy for cancer chemotherapy. Doxycycline (DC) is a kind of antibiotics but also inhibits tumorigenesis.MethodsMTT and cell invasion assay, flow cytometry, western ...
Wei Wu, Li-Hua Yu, Bei Ma, Ming-Juan Xu
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Frontiers in Microbiology, 2023 BackgroundFour randomized controlled trials have now established that doxycycline post exposure (sex) prophylaxis (PEP) can reduce the incidence of chlamydia and syphilis in men who have sex with men.
Chris Kenyon +9 more
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Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice. [PDF]
PLoS ONE, 2012 There is no proven medical approach to attenuating expansion and rupture of abdominal aortic aneurysms (AAAs). One approach that is currently being investigated is the use of doxycycline. Despite being primarily used as an antimicrobial drug, doxycycline
Xiaojie Xie +6 more
doaj +1 more source
Gateway vectors for efficient artificial gene assembly in vitro and expression in yeast Saccharomyces cerevisiae [PDF]
Giuraniuc CV, MacPherson M, Saka Y (2013) PLoS ONE 8(5): e64419, 2012 Construction of synthetic genetic networks requires the assembly of DNA fragments encoding functional biological parts in a defined order. Yet this may become a time-consuming procedure. To address this technical bottleneck, we have created a series of Gateway shuttle vectors and an integration vector, which facilitate the assembly of artificial genes ...
arxiv +1 more source