Results 11 to 20 of about 8,468,904 (256)

The Prevalence of Potential Drug-Drug-Gene Interactions: A Descriptive Study Using Swiss Claims Data [PDF]

Pharmacogenomics and Personalized Medicine
Nina L Wittwer,1,2 Christoph R Meier,1– 3 Carola A Huber,4 Julie D Moser,1 Henriette E Meyer zu Schwabedissen,5 Samuel S Allemann,6,* Cornelia Schneider1,2,* 1Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology,
Wittwer NL, Meier CR, Huber CA, Moser JD, Meyer zu Schwabedissen HE, Allemann SS, Schneider C   +6 more
doaj   +1 more source

Impact of Drug-Gene-Interaction, Drug-Drug-Interaction, and Drug-Drug-Gene-Interaction on (es)Citalopram Therapy: The PharmLines Initiative. [PDF]

J Pers Med, 2020
We explored the association between CYP2C19/3A4 mediated drug-gene-interaction (DGI), drug-drug-interaction (DDI) and drug-drug-gene-interaction (DDGI) and (es)citalopram dispensing course.
Bahar MA, Lanting P, Bos JHJ, Sijmons RH, Hak E, Wilffert B.   +5 more
europepmc   +2 more sources

A Review of Current In Silico Methods for Repositioning Drugs and Chemical Compounds

Frontiers in Oncology, 2021
Drug repositioning is a new way of applying the existing therapeutics to new disease indications. Due to the exorbitant cost and high failure rate in developing new drugs, the continued use of existing drugs for treatment, especially anti-tumor drugs ...
Binsheng He, Fangxing Hou, Changjing Ren, Changjing Ren, Pingping Bing, Xiangzuo Xiao   +5 more
doaj   +1 more source

Pharmacogenomic network analysis of the gene-drug interaction landscape underlying drug disposition

Computational and Structural Biotechnology Journal, 2020
In recent decades the identification of pharmacogenomic gene-drug associations has evolved tremendously. Despite this progress, a major fraction of the heritable inter-individual variability remains elusive.
Yitian Zhou, Volker M. Lauschke
doaj   +1 more source

Drug repositioning in non-small cell lung cancer (NSCLC) using gene co-expression and drug–gene interaction networks analysis

Scientific Reports, 2022
Lung cancer is the most common cancer in men and women. This cancer is divided into two main types, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Around 85 to 90 percent of lung cancers are NSCLC.
Habib MotieGhader, Parinaz Tabrizi-Nezhadi, Mahshid Deldar Abad Paskeh, Behzad Baradaran, Ahad Mokhtarzadeh, Mehrdad Hashemi, Hossein Lanjanian, Seyed Mehdi Jazayeri, Masoud Maleki, Ehsan Khodadadi, Sajjad Nematzadeh, Farzad Kiani, Mazaher Maghsoudloo, Ali Masoudi-Nejad   +13 more
doaj   +1 more source

Text Mining-Based Drug Discovery for Connective Tissue Disease–Associated Pulmonary Arterial Hypertension

Frontiers in Pharmacology, 2022
Background: The current medical treatments for connective tissue disease–associated pulmonary arterial hypertension (CTD-PAH) do not show favorable efficiency for all patients, and identification of novel drugs is desired.Methods: Text mining was ...
Jiang-Shan Tan, Song Hu, Ting-Ting Guo, Lu Hua, Xiao-Jian Wang   +4 more
doaj   +1 more source

Drug metabolism and liver disease: a drug–gene–environment interaction [PDF]

, 2017
Despite the central role of the liver in drug metabolism, surprisingly there is lack of certainty in anticipating the extent of modification of the clearance of a given drug in a given patient.
Khoueiry-Zgheib, Nathalie, Branch, Robert A.   +1 more
core   +1 more source

Drug-drug interactions in the hospital [PDF]

, 2007
Introduction Drug interaction screening programs are an important tool to check prescriptions of multiple drugs for potential drug-drug interactions (pDDIs). Several programs are available on the market.
Vonbach, Priska
core   +1 more source

Impact of study design and statistical model in pharmacogenetic studies with gene‐treatment interaction

CPT: Pharmacometrics & Systems Pharmacology, 2021
Gene‐treatment interactions, just like drug‐drug interactions, can have dramatic effects on a patient response and therefore influence the clinician decision at the patient’s bedside.
Camille Couffignal, France Mentré, Julie Bertrand   +2 more
doaj   +1 more source

12621 Targeted Chemical-Genetic Screen Platform for Identifying Drug Modes-of-Action

Journal of Clinical and Translational Science, 2021
IMPACT: The key to advancing precision medicine is to deepen our understanding of drug modes-of-action (MOA). This project aims to develop a novel method for predicting MOA of potential drug compounds, providing an experimental and computational platform
Kevin Lin, Maximilian Billmann, Henry Ward, Ya-Chu Chang, Anja-Katrin Bielinsky, Chad L. Myers   +5 more
doaj   +1 more source