Results 61 to 70 of about 8,468,904 (256)

Pharmacogenetics of drug-drug interaction and drug-drug-gene interaction:A systematic review on CYP2C9, CYP2C19 and CYP2D6 [PDF]

, 2017
Currently, most guidelines on drug-drug interaction (DDI) neither consider the potential effect of genetic polymorphism in the strength of the interaction nor do they account for the complex interaction caused by the combination of DDI and drug-gene ...
Setiawan, Didik, Bahar, Muh Akbar, Wilffert, Bob, Hak, Eelko, Bob Wilffert, Muh Akbar Bahar, Didik Setiawan, Eelko Hak   +7 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

AddictGene: An integrated knowledge base for differentially expressed genes associated with addictive substance

Computational and Structural Biotechnology Journal, 2021
Addiction, a disorder of maladaptive brain plasticity, is associated with changes in numerous gene expressions. Nowadays, high-throughput sequencing data on addictive substance-induced gene expression have become widely available.
Leisheng Shi, Yan Wang, Chong Li, Kunlin Zhang, Quansheng Du, Mei Zhao   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Monoamine Oxidase Inhibitors – Indirect Acting Sympathomimetics - contextualized potential drug-drug interaction clinical algorithm

, 2018
An algorithm developed for research purposes that summarizes the potential drug-drug interaction between Monoamine Oxidase Inhibitors – Indirect Acting Sympathomimetics. The information is not advice, and should not be treated as such. The information is
Contributors to the A Minimum Representation of Potential Drug-Drug Interaction Knowledge and Evidence - Technical and User-centered Foundation Specification
core   +1 more source

Candidate drug molecules (top ten) identified from gene-drug interaction enrichment analysis.

, 2022
Candidate drug molecules (top ten) identified from gene-drug interaction enrichment analysis.
Yun Chen (279569), Ying Zhao (16546), Chenyun Miao (10668003), Xiaojie Fang (8319717), Qin Zhang (58638), Ruye Wang (3986681)   +5 more
core   +1 more source

Drug Combination Recommendation Model for Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Pharmaceuticals
Background: Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) are two common autoimmune disorders for which the choice of drug regimen is clinically crucial.
Ling Wang, Zhengyang Zhang, Ziheng Zhang, Tie Hua Zhou, Keun Ho Ryu   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source