Results 81 to 90 of about 1,966,062 (257)

Clozapine treatment in patients living in the community [PDF]

, 2015
OBJECTIVE: The aim of this study was to assess clozapine treatment in the local community with respect to patient monitoring during dispensing, patient compliance through prescription refills, presence of any other existing co-morbidities and ...
Azzopardi, Lilian M., Schembri, Karl
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Antimicrobial and Anti-Inflammatory Potentials of Silver Tungstate Nanoparticles, Cytotoxicity and Interference on the Activity of Antimicrobial Drugs

Drugs and Drug Candidates
Background: Bacterial resistance to antimicrobial drugs is a critical phenomenon that is hampering clinical treatments, raising the need for promising compounds that can be explored as pharmaceutical products.
Washington de Souza Leal, Juliane Zacour Marinho, Isabela Penna Ceravolo, Lucas Leão Nascimento, Antonio Otávio de Toledo Patrocínio, Marcus Vinícius Dias-Souza   +5 more
doaj   +1 more source

Detecting drug interactions using personal digital assistants in an out-patient clinic [PDF]

, 2017
Background: The installation of drug databases on personal digital assistants (PDAs) allows for rapid detection of adverse drug interactions at the point of care.
Bovier, P.A., Dallenbach, M.Francis, Desmeules, J.   +2 more
core  

Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations. [PDF]

, 2019
Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patients.
Alvarez-Cabrera, Nadine, Blanc, Landry, Dartois, Véronique, Dias-Freedman, Isabela, Dietzold, Jillian, Ho Liang, Hsin-Pin, Kaya, Firat, Kirschner, Denise, Linderman, Jennifer, Mina, Marizel, O'Brien, Paul, Pienaar, Elsje, Prideaux, Brendan, Salgame, Padmini, Sarathy, Jansy, Savic, Radojka M, Zimmerman, Matthew   +16 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Metabolism, Transport and Drug–Drug Interactions of Silymarin

Molecules, 2019
Silymarin, the extract of milk thistle, and its major active flavonolignan silybin, are common products widely used in the phytotherapy of liver diseases.
Ying Xie, Dingqi Zhang, Jin Zhang, Jialu Yuan   +3 more
doaj   +1 more source

DPDDI: a deep predictor for drug-drug interactions

BMC Bioinformatics, 2020
Background The treatment of complex diseases by taking multiple drugs becomes increasingly popular. However, drug-drug interactions (DDIs) may give rise to the risk of unanticipated adverse effects and even unknown toxicity.
Yue-Hua Feng, Shao-Wu Zhang, Jian-Yu Shi
doaj   +1 more source

Local and global modes of drug action in biochemical networks [PDF]

, 2008
It becomes increasingly accepted that a shift is needed from the traditional target-based approach of drug development to an integrated perspective of drug action in biochemical systems. We here present an integrative analysis of the interactions between
A Ma'ayan, A Petrelli, C Lengauer, DB Kell, DS Lee, DS Wishart, EC Butcher, F Matthäus, F Sams-Dodd, GV Paolini, J Barthelmes, J Raymond, JA DiMasi, JC Nacher, Jean-Marc Schwartz, JH Kim, JJ Hornberg, Jose C Nacher, M Kanehisa, MA Yıldırım, MC Fishman, MI Siegel, O Ebenhöh, P Csermely, SB Seidman, T Handorf, T Handorf, T Handorf, T Handorf, V Batagelj, Z Spiro   +30 more
core   +4 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source