Results 91 to 100 of about 783,471 (282)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hepatotoxicity and rhabdomyolysis in kidney transplant patient with COVID-19: possible role of remdesivir and atorvastatin drug-drug-gene interactions [PDF]

, 2022
Introduction: Because of very variable clinical presentation of COVID-19 and polypharmacy in elderly, sometimes is difficult to distinguish between the drug-drug, disease-drug or drug- druggene induced side effects. Description: A 63–year old Caucasian woman with kidney transplant, was hospitalized due to COVID-19 infection.
Božina, Tamara, Šimičević, Livija, Osmanović, Jelena, Božina, Nada, Ganoci, Lana   +4 more
openaire  

Compliance with national guidelines for the management of drug-drug interactions in Dutch community pharmacies.

, 2007
Item does not contain fulltextBACKGROUND: Pharmacists contribute to the detection and prevention of drug therapy-related problems, including drug-drug interactions.
Schalekamp, T., Dep Farmaceutische wetenschappen, Smet, P.A.G.M. de, Population-based studies of drug treatment: from molecule to patient outcomes, Egberts, A.C.G., de Smet, A.G.M., Buurma, H.   +6 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Pharmacogenetics of drug-drug interaction and drug-drug-gene interaction

Pharmacogenomics, 2017
Currently, most guidelines on drug-drug interaction (DDI) neither consider the potential effect of genetic polymorphism in the strength of the interaction nor do they account for the complex interaction caused by the combination of DDI and drug-gene interaction (DGI) where there are multiple biotransformation pathways, which is referred to as drug-drug-
Bahar, Muh Akbar, Setiawan, Didik, Hak, Eelko, Wilffert, Bob   +3 more
openaire   +1 more source

Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review.

Arhiv za higijenu rada i toksikologiju, 2021
Concomitant treatment with drugs that inhibit drug metabolising enzymes and/or transporters, such as commonly prescribed statins and nonsteroidal anti- inflammatory drugs (NSAIDs), has been associated with prolonged drug exposure and increased risk of adverse drug reactions (ADRs) due to drug-drug interactions. The risk is further increased in patients
Božina, Nada, Ganoci, Lana, Šimičević, Livija, Gvozdanović, Katarina, Klarica Domjanović, Iva, Borić Bilušić, Ana, Laganović, Mario, Božina, Tamara   +7 more
openaire   +1 more source

Protocol to estimate the heritability of drug response with GxEMM and identify gene-drug interactions with TxEWAS

STAR Protocols
Summary: Identifying factors that affect treatment response is a central objective of clinical research. Here, we present a protocol to study the genetic architecture of response to commonly prescribed drugs using gene-context interaction techniques.
Michal Sadowski, Andy W. Dahl, Noah Zaitlen   +2 more
doaj   +1 more source

Citalopram: suspected drug interaction with cocaine; prescribers should consider enquiring about illicit drug use.

, 2016
The UK Medicines and Healthcare products Regulatory Agency received a Coroner’s report that raised concerns about a suspected drug interaction between citalopram and cocaine after the death of a man due to subarachnoid haemorrhage.

core  

Clinical risk management in Dutch community pharmacies: the case of drug-drug interactions.

, 2006
Item does not contain fulltextBACKGROUND: The prevention of drug-drug interactions requires a systematic approach for which the concept of clinical risk management can be used.
Dep Farmaceutische wetenschappen, Smet, P.A.G.M. de, Population-based studies of drug treatment: from molecule to patient outcomes, Egberts, A.C.G., de Smet, P.G.A.M., Buurma, H.   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source