Results 91 to 100 of about 8,468,954 (280)

Drug-gene target prioritization.

, 2018
Drug-gene target prioritization.
Rozemarijn S. van Rijn (4898842), Gerwin Huls (3371285), Arjan Diepstra (151995), Emanuele Ammatuna (4898836), Rudolf S. N. Fehrmann (87558), Edo Vellenga (256890), Mathilde R. W. de Jong (4898845), Tom van Meerten (4898833), Lydia Visser (151980), Marcel van Vugt (4898839), Anke van den Berg (80131)   +10 more
core   +1 more source

Hepatotoxicity and rhabdomyolysis in kidney transplant patient with COVID-19: possible role of remdesivir and atorvastatin drug-drug-gene interactions [PDF]

, 2022
Introduction: Because of very variable clinical presentation of COVID-19 and polypharmacy in elderly, sometimes is difficult to distinguish between the drug-drug, disease-drug or drug- druggene induced side effects. Description: A 63–year old Caucasian woman with kidney transplant, was hospitalized due to COVID-19 infection.
Božina, Tamara, Šimičević, Livija, Osmanović, Jelena, Božina, Nada, Ganoci, Lana   +4 more
openaire  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Associations between antihypertensive drug-related gene polymorphisms and cardiovascular outcomes in hypertensive patients: a gene-drug interaction study

Scientific Reports
Antihypertensive therapy is pivotal in preventing cardiovascular events, yet treatment efficacy varies significantly among individuals due to genetic polymorphisms.This study aimed to investigate the association between specific antihypertensive drug ...
Zetong Li, Huixia Liu, Mengshi Chen, Jing Deng, Ziyu Ma, Ge Huang, Cheng Li, Meng Su, Hua Zhong   +8 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Citalopram: suspected drug interaction with cocaine; prescribers should consider enquiring about illicit drug use.

, 2016
The UK Medicines and Healthcare products Regulatory Agency received a Coroner’s report that raised concerns about a suspected drug interaction between citalopram and cocaine after the death of a man due to subarachnoid haemorrhage.

core  

BCR-ABL Tyrosine Kinase Inhibitors (TKI) + Proton Pump Inhibitors (PPI) - contextualized potential drug-drug interaction clinical algorithm

, 2018
An algorithm developed for research purposes that summarizes the potential drug-drug interaction between BCR-ABL Tyrosine Kinase Inhibitors (TKI) + Proton Pump Inhibitors (PPI). The information is not advice, and should not be treated as such.
Contributors to the A Minimum Representation of Potential Drug-Drug Interaction Knowledge and Evidence - Technical and User-centered Foundation Specification
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Toward More Open, Theoretically Grounded, and Sustainable Parental Involvement in Applied Behavior Analysis Interventions for Children with Autism Spectrum Disorder [Letter]

Psychology Research and Behavior Management
Shujuan Chen,1 Qing-Wei Chen2–4 1Department of Psychology, School of Education, Ningxia University, Yinchuan, People’s Republic of China; 2Lab of Light and Physio-Psychological Health, National Center for International Research on ...
Chen S, Chen QW
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source