Results 251 to 260 of about 783,471 (282)

Identification of neutrophil-related genes associated with the severity of RSV infection. [PDF]

Microbiol Spectr
Zhang D, Zhang H, Zhang X, Yin L, Shao X, Hua S.   +5 more
europepmc   +1 more source

Multi-omics feature engineering driven by biomedical foundation models improves drug response prediction for inflammatory bowel disease patients. [PDF]

Sci Rep
Gardiner LJ, Kelly J, Evans A, Checkley S, Bingham K, Macluskie G, Bunton D.   +6 more
europepmc   +1 more source

Single-cell transcriptomics uncovers heterogenous cell clusters and the biomarker FUT11 in ovarian cancer progression. [PDF]

Cancer Cell Int
Chen Q, Liu Z, Wang J, Teng Y, Jiang M, Yue W.   +5 more
europepmc   +1 more source

A network-based deep learning model integrating subclonal architecture for therapy response prediction in cancer. [PDF]

Cell Rep Methods
Kim S, Ha D, Nam AR, Cheong S, Lee J, Kim S, Park S.   +6 more
europepmc   +1 more source

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Drug–drug–gene interaction risk among opioid users in the U.S. Department of Veterans Affairs

Pain, 2022
Abstract Response to analgesic therapy is influenced by several factors including genetics and drug–drug interactions. Pharmacogenetic (PGx) variants in the CYP2D6 gene modify response to opioids by altering drug metabolism. We sought to determine the potential impact of PGx testing on the care of Veterans with noncancer pain prescribed ...
Catherine Chanfreau-Coffinier, Sony Tuteja, Leland E. Hull, Sally MacDonald, Olga Efimova, Jill Bates, Deepak Voora, David W. Oslin, Scott L. DuVall, Julie A. Lynch   +9 more
openaire   +2 more sources

Insights into pharmacogenetics, drug-gene interactions, and drug-drug-gene interactions

Drug Metabolism Reviews
This review explores genetic contributors to drug interactions, known as drug-gene and drug-drug-gene interactions (DGI and DDGI, respectively). This article is part of a mini-review issue led by the International Society for the Study of Xenobiotics (ISSX) New Investigators Group.
Laura E. Russell, Katrina G. Claw, Kaja M. Aagaard, Sarah M. Glass, Kuheli Dasgupta, F. Leah Nez, Alex Haimbaugh, Benjamin J. Maldonato, Jaydeep Yadav   +8 more
openaire   +2 more sources

Severe hyperglycaemia following pazopanib treatment: The role of drug‐drug‐gene interactions in a patient with metastatic renal cell carcinoma—A case report

Journal of Clinical Pharmacy and Therapeutics, 2020
Pazopanib is a tyrosine kinase inhibitor with hyperglycaemia as a known adverse event, but case reports of severe hyperglycaemia are exceptional. We report a case of severe hyperglycaemia following pazopanib administration in a patient with metastatic renal cell carcinoma.Severe hyperglycaemia developed in a patient one month following initiation of ...
Darija Kuruc Poje, Nada Božina, Livija Šimičević, Igor Žabić   +3 more
openaire   +4 more sources

PM-TOM: A Method for Finding Personalized Polypharmacy Therapies with Minimal Adverse Drug-Drug, Drug-Gene and Drug-Condition Interactions

2020
Polypharmacy therapies, quite frequent in older populations, pose significant health risks for patients due to a high possibility of their cumulative adverse drug reactions. We present Personalized Medicine Therapy Optimization Method (PM-TOM) for the discovery of polypharmacy therapies with minimal drug-drug interactions, drug-gene interactions, and ...
Adnan Kulenovic, Azra Lagumdzija-Kulenovic   +1 more
openaire   +2 more sources