Results 261 to 270 of about 783,471 (282)

Model Informed Drug Development and Precision Dosing for Drug-Drug-Gene-Interactions: Application of Physiologically-Based Pharmacokinetic Modeling

2021
Der globale Arzneimittelbedarf steigt kontinuierlich an. Infolgedessen kommt es vermehrt zu unerwünschten Arzneimittelwirkungen, die eine Gefahr für Patienten darstellen. Eine wichtige Rolle beim Auftreten unerwünschter Arzneimittelwirkungen spielen Arzneimittel-Arzneimittel- und Arzneimittel-Gen-Wechselwirkungen. Um das Risiko solcher Wechselwirkungen
openaire   +1 more source

Rhabdomyolysis in kidney transplant patient with COVID-19: possible role of remdesivir and atorvastatin drug-drug-gene interactions

2022
Introduction Because of very variable clinical presentation of Covid-19 and polypharmacy in elderly, sometimes is difficult to distinguish between the drug-drug, disease- drug or drug-drug-gene induced side effects. Description A 63 –year old Caucasian woman with kidney transplant, was hospitalized due to Covid-19 infection.
Božina, Nada, Šimičević, Livija, Osmanović, Jelena, Ganoci, Lana   +3 more
openaire  

Opioid-Related Genetic Polymorphisms of Cytochrome P450 Enzymes after Total Joint Arthroplasty: A Focus on Drug-Drug-Gene Interaction with Commonly Coprescribed Medications.

The Orthopedic clinics of North America, 2022
Pharmacogenomic testing, together with the early detection of drug-drug-gene interactions (DDGI) before initiating opioids, can improve the selection of dosage and reduce the risk of adverse drug interactions and therapeutic failures following Total Joint Arthroplasty. The variants of CYP genes can mediate DDGI.
Brendan J, Farley, Mohamed E, Awad, Paige, Anderson, Ali S, Esseili, Justin, Hruska, Gamal, Mostafa, Khaled J, Saleh   +6 more
openaire   +1 more source

Severe CNS depression with duloxetine, ciprofloxacin and CYP2D6 deficiency—role and recognition of drug-drug-gene interactions

European Journal of Clinical Pharmacology, 2022
Matthias Hoffmann, Stefan Russmann, David F. Niedrig   +2 more
openaire   +2 more sources

Integration of the Drug–Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts

Nucleic Acids Research, 2021
Sharon L Freshour, Susanna Kiwala, Kelsy C Cotto   +2 more
exaly  

Comparing potential drug-drug-gene interactions across age groups in a population of individuals utilizing a community-based pharmacy

The American Journal of Geriatric Psychiatry, 2023
Daniel Dowd, Russell Amato, David Krause
openaire   +1 more source

Prediction of multi-relational drug–gene interaction via Dynamic hyperGraph Contrastive Learning

Briefings in Bioinformatics, 2023
Yuansheng Liu, Bosheng Song, Xiangxiang Zeng   +2 more
exaly  

Benchmarking blockchain-based gene-drug interaction data sharing methods: A case study from the iDASH 2019 secure genome analysis competition blockchain track

International Journal of Medical Informatics, 2021
Tsung-Ting Kuo, Tyler Bath, Meng Yang
exaly  

Novel method for the prediction of drug-drug Interaction based on gene expression profiles

European Journal of Pharmaceutical Sciences, 2021
Y-H Taguchi, Turki Turki
exaly  

Novel models for the prediction of drug–gene interactions

Expert Opinion on Drug Metabolism and Toxicology, 2021
Denise Türk, Laura Maria Fuhr, Fatima Zahra Marok   +2 more
exaly