Results 241 to 250 of about 2,202,582 (329)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Effect of Valemetostat on the Pharmacokinetics of Midazolam and Digoxin: A Phase 1 Drug-Drug Interaction Study in Patients With Non-Hodgkin Lymphoma. [PDF]

Clin Transl Sci
Tachibana M, Horwitz S, Jacobsen E, Foss F, Allen P, Porcu P, Feldman T, Ruan J, Brammer JE, Wang J, Inaba S, Iko Y, Nakajima K, Kakurai Y, Kitami N, Chen Y, Lau Y.   +16 more
europepmc   +1 more source

Systematic review and synthesis without meta-analysis (SWiM) reveals lack of clinical studies and weak preclinical evidence for interaction between glucose regulating drugs and environmental contaminant exposure

Kimberley A. Bennett, Ruslan Gouleguine, Calum Sutherland, Anne Savage   +3 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Enhanced drug-drug interaction extraction from biomedical text using deep learning-based sentence representations. [PDF]

Sci Rep
Tahir MT, Ibrahim M, Sarwar N, Irshad A, Atteia G.   +4 more
europepmc   +1 more source

Improvement of Gastroparesis Management By Addressing Challenges in Drug Metabolism: Studies with Metabolite Identification, Reaction Phenotyping and In Vitro Drug-Drug Interactions

, 2013
Amir S. Youssef
openalex   +1 more source

Drug-substrate interactions from a theory-based databank of transferable pseudoatoms and potential curves derived from advanced theoretical calculations.

, 2005
Philip Coppens, Anatoliy Volkov, Xue Li, P.M. Dominiak   +3 more
openalex   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Corrigendum to “Effect of a probiotic mixture on the biotransformation and bioavailability of deglycosylated ginsenosides” [J. Funct. Foods 133 (2025) 107015]

Journal of Functional Foods
So Yeon Jeon, Jihoon Lee, Ji-Hyeon Jeon, Juyoung Kim, Yeon-Ju Baek, Min-Koo Choi, Soohyun Sung, Jong Won Kim, Sanghyun Lim, Im-Sook Song   +9 more
doaj   +1 more source

Implementation of an Online Drug-Drug Interaction Screener for the STRIVE Ensitrelvir Trial for COVID-19. [PDF]

Open Forum Infect Dis
Havens JP, Kang N, Chung L, Fletcher CV, Crew P, Nordwall J, Siegel L, Harper K, Grund B, Losso M, Vasudeva S, Molina KC, Ginde AA, Shimizu R, Mourad A, Diallo A, Pak M, Davis-Karim A, Nabaggala P, Mena Lora AJ, Russell DW, Saito S, Baker JV.   +22 more
europepmc   +1 more source