Results 241 to 250 of about 6,006,054 (377)

A meta-contrastive learning approach for clinical drug-drug interaction extraction from biomedical literature. [PDF]

PLoS Comput Biol
Jia Y, Yuan Z, Zhu L, Xiang ZL.
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Research on drug-drug interaction prediction using capsule neural network based on self-attention mechanism. [PDF]

BMC Bioinformatics
Chen X, Wang Z, Miao Z, Nie B.
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug-Drug Interaction Predictions. [PDF]

Clin Pharmacol Ther
Taskar KS, Sharma P, Rowland Yeo K.
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

PS3N: leveraging protein sequence-structure similarity for novel drug-drug interaction discovery. [PDF]

Sci Rep
Islam S, Abbasi A, Agarwal N, Zheng W, Doretto G, Adjeroh DA.   +5 more
europepmc   +1 more source

In vitro evaluation of selected Indian spices for α-amylase and α-glucosidase inhibitory activities and their spice-drug interactions

, 2019
Nupur Mehrotra, Kaustubh Jadhav, Swati Rawalgaonkar, Sara Anees Khan, B. R. PAREKH   +4 more
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Adverse Drug-Drug Interaction Between Phenobarbital and Fluconazole in Two Dogs. [PDF]

J Vet Intern Med
Jaramillo M, Mondino A, Court M, Lewis MJ, Olby NJ, Muñana KR.   +5 more
europepmc   +1 more source