Results 11 to 20 of about 7,761,818 (273)
Drug-Drug-Gene Interactions in Cardiovascular Medicine. [PDF]
Pharmgenomics Pers Med, 2022 Cardiovascular disease remains a leading cause of both morbidity and mortality worldwide. It is widely accepted that both concomitant medications (drug-drug interactions, DDIs) and genomic factors (drug-gene interactions, DGIs) can influence cardiovascular drug-related efficacy and safety outcomes. Although thousands of DDI and DGI (aka pharmacogenomic)
Asiimwe IG, Pirmohamed M.
europepmc +10 more sources
CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids. [PDF]
Appl Nurs Res, 2017 When codeine and tramadol are used for pain management, it is imperative that nurses are able to assess for potential drug-gene and drug-drug-gene interactions that could adversely impact drug metabolism and ultimately pain relief. Both drugs are metabolized through the CYP2D6 metabolic pathway which can be affected by medications as well the patient's
Knisely MR +6 more
europepmc +7 more sources
DGIdb 2.0: mining clinically relevant drug-gene interactions. [PDF]
Nucleic Acids Res, 2016 The Drug-Gene Interaction Database (DGIdb, www.dgidb.org) is a web resource that consolidates disparate data sources describing drug-gene interactions and gene druggability. It provides an intuitive graphical user interface and a documented application programming interface (API) for querying these data.
Wagner AH +14 more
europepmc +9 more sources
Drug-drug-gene interactions and adverse drug reactions. [PDF]
Pharmacogenomics J, 2020 AbstractThe economic and health burden caused by adverse drug reactions has increased dramatically in the last few years. This is likely to be mediated by increasing polypharmacy, which increases the likelihood for drug–drug interactions. Tools utilized by healthcare practitioners to flag potential adverse drug reactions secondary to drug–drug ...
Malki MA, Pearson ER.
europepmc +7 more sources
Drug‐Drug‐Gene Interactions: A Call for Clinical Consideration [PDF]
Clinical Pharmacology & Therapeutics, 2021 It is widely accepted that both comedications and genetic factors may contribute to variation of drug response. Clinical decision support systems increasingly consider recommendations on drug– drug interactions (DDIs) during electronic prescribing, and some guidelines on drug–gene-interactions (DGI) have been implemented in drug labels.
Bruckmüller, Henrike, Cascorbi, Ingolf
openaire +5 more sources
Drug-Gene Interactions between Genetic Polymorphisms and Antihypertensive Therapy [PDF]
Drugs, 2004 Genetic factors may influence the response to antihypertensive medication. A number of studies have investigated genetic polymorphisms as determinants of cardiovascular response to antihypertensive drug therapy. In most candidate gene studies, no such drug-gene interactions were found. However, there is observational evidence that hypertensive patients
Schelleman, H +7 more
openaire +7 more sources
Primary Care Prescription Drug Use and Related Actionable Drug‐Gene Interactions in the Danish Population [PDF]
Clinical and Translational Science, 2020 Pharmacogenetics (PGx) aims to improve drug therapy using the individual patients’ genetic make‐up. Little is known about the potential impact of PGx on the population level, possibly hindering implementation of PGx in clinical care.
Carin Adriana Theodora Catharina Lunenburg +3 more
doaj +2 more sources
Towards personalized management of drug interactions: from drug-drug-interaction to drug-drug-gene-interaction [PDF]
, 2020 Drug-drug interactions (DDIs) are still an important contributor to ineffective treatment or deleterious side effects. Therefore, assessing the prevalence and clinical relevance of frequently observed potential DDIs is an important step towards improving medication safety.
Bahar, Akbar
openaire +4 more sources
Role of Drug-Gene Interactions and Pharmacogenetics in Simvastatin-Associated Pulmonary Toxicity. [PDF]
Drug Saf, 2021 Simvastatin has previously been associated with drug-induced interstitial lung disease. In this retrospective observational study, cases with non-specific interstitial pneumonia (NSIP) or idiopathic pulmonary fibrosis (IPF) with simvastatin-associated pulmonary toxicity (n = 34) were evaluated.To identify whether variations in genes encoding cytochrome
Jessurun NT +6 more
europepmc +5 more sources
Impact of Drug-Gene-Interaction, Drug-Drug-Interaction, and Drug-Drug-Gene-Interaction on (es)Citalopram Therapy: The PharmLines Initiative [PDF]
Journal of Personalized Medicine, 2020 We explored the association between CYP2C19/3A4 mediated drug-gene-interaction (DGI), drug-drug-interaction (DDI) and drug-drug-gene-interaction (DDGI) and (es)citalopram dispensing course. A cohort study was conducted among adult Caucasians from the Lifelines cohort (167,729 participants) and linked dispensing data from the IADB.nl database as part of
Muh. Akbar Bahar +5 more
openaire +3 more sources