Results 71 to 80 of about 7,761,818 (273)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Drug–gene and drug–drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial

, 2019
Background: Tramadol and codeine are metabolized by CYP2D6 and are subject to drug-gene and drug-drug interactions. Methods: This interim analysis examined prescribing behavior and efficacy in 102 individuals prescribed tramadol or codeine while ...
Decker, Brian S., Zang, Yong, Pratt, Victoria M., Skaar, Todd C., Holmes, Ann M., Eadon, Michael T., Zhang, Yifei, Gufford, Brandon T., Dexter, Paul R., Rosenman, Marc B., Fulton, Cathy R., Desta, Zeruesenay, Callaghan, John T., Levy, Kenneth D.   +13 more
core   +1 more source

Physiologically‐Based Pharmacokinetic Modeling for the Prediction of CYP2D6‐Mediated Gene–Drug–Drug Interactions

CPT: Pharmacometrics & Systems Pharmacology, 2019
The aim of this work was to predict the extent of Cytochrome P450 2D6 (CYP2D6)‐mediated drug–drug interactions (DDIs) in different CYP2D6 genotypes using physiologically‐based pharmacokinetic (PBPK) modeling. Following the development of a new duloxetine
Flavia Storelli, Jules Desmeules, Youssef Daali   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

DRUGPATH: The Drug Gene Pathway Meta-Database

, 2020
The complexity of modern-day diseases often requires drug treatment therapies consisting of multiple pharmaceutical interventions, which can lead to adverse drug reactions for patients.
Rajeev Jaundoo, Craddock, Travis J A, Travis J. A. Craddock, Jaundoo, Rajeev   +3 more
core   +1 more source

An overview of interactions between micronutrients and of micronutrients with drugs, genes and immune mechanisms [PDF]

Nutrition Research Reviews, 2004
AbstractThe objective of the present review is to examine critically the consequences of interactions that micronutrients undergo with nutrients and non-nutrients (mainly prescribed medicines) in diets and lifestyle factors (smoking, tea and alcohol consumption). In addition, the review describes recent work on interactions between nutrients and genes,
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Impact of study design and statistical model in pharmacogenetic studies with gene‐treatment interaction

CPT: Pharmacometrics & Systems Pharmacology, 2021
Gene‐treatment interactions, just like drug‐drug interactions, can have dramatic effects on a patient response and therefore influence the clinician decision at the patient’s bedside.
Camille Couffignal, France Mentré, Julie Bertrand   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

HCDT 2.0: A Highly Confident Drug-Target Database for Experimentally Validated Genes, RNAs, and Pathways

Scientific Data
Drug-target interactions constitute the fundamental basis for understanding drug action mechanisms and advancing therapeutic discovery. While existing drug-target databases have contributed valuable resources, they exhibit structural and functional ...
Xinying Liu, Dehua Feng, Jiaqi Chen, Tianyi Li, Xuefeng Wang, Ruijie Zhang, Jian Chen, Xingjun Cai, Huirui Han, Lei Yu, Xia Li, Bing Li, Limei Wang, Jin Li   +13 more
doaj   +1 more source