Results 51 to 60 of about 7,761,818 (273)
VitaeDrug interactions are quantitative changes in the intensity or duration of a drug's effect that may result in therapeutic failure or adverse effects due to: (a) the previous or concomitant use of another drug, herbal medicinal product, or food; (b ...
Pedro Amariles
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, 2022 Aim: Prospective studies support the clinical impact of pharmacogenomics (PGx)-guided prescribing to reduce severe and potentially fatal adverse effects.
Heiralde Marck (12966755) +4 more
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Cancer Informatics, 2018 Understanding gene-gene interaction and its causal relationship to protein-protein interaction is a viable route for understanding drug action at the genetic level, which is largely hindered by inability to robustly map gene regulatory networks. Here, we
Adel Aloraini, Karim M ElSawy
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PLoS ONE, 2022 In recent years, drug sensitivity prediction has garnered a great deal of attention due to the growing interest in precision medicine. Several computational methods have been developed for drug sensitivity prediction and the identification of related ...
Heewon Park +3 more
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Potential drug interactions : exposure and management in hospital and ambulatory settings [PDF]
, 2006 Health care professionals are responsible to ensure safe dispensing and use of drug regimens involving the use of drug combinations that may interact and cause serious adverse events.
Indermitte, Jörg Lorenz
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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, 2016 data for Fig.5: gene-fam-with-drug-target.txt column 1: HGNC gene family ID or name column 2: number of drug target genes (gene products) in the (HGNC) gene family column 3: number of genes in the (HGNC) gene family (possibly including pseudogenes ...
Wentian Li (28857) +5 more
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