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, 2006 Drug-induced liver injury (DILI) is common and nearly all classes of medications can cause liver disease. Most cases of DILI are benign, and improve after drug withdrawal. It is important to recognize and remove the offending agent as quickly as possible to prevent the progression to chronic liver disease and/or acute liver failure.
Herbert L. Bonkovsky +3 more
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Critical Care Nursing Clinics of North America, 2022
Drug-induced liver injury (DILI) is a spectrum of liver injuries that can be classified by phenotype and injury patterns. Some injury patterns can be predicted in a number of drugs that are commonly used in practice, but idiosyncratic reactions are unpredictable and are not dose related.
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Drug-induced liver injury (DILI) is a spectrum of liver injuries that can be classified by phenotype and injury patterns. Some injury patterns can be predicted in a number of drugs that are commonly used in practice, but idiosyncratic reactions are unpredictable and are not dose related.
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2018
The chapter on drug-induced liver injury discusses the definition, clinical manifestations, and then management of this frequently challenging to diagnose situation. It also covers in more detail the management of paracetamol overdose.
Fevronia Kiparissi, Rob Hegarty
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The chapter on drug-induced liver injury discusses the definition, clinical manifestations, and then management of this frequently challenging to diagnose situation. It also covers in more detail the management of paracetamol overdose.
Fevronia Kiparissi, Rob Hegarty
openaire +3 more sources
Drug-Induced Hepatotoxicity or Drug-Induced Liver Injury
Clinics in Liver Disease, 2009Drug-induced hepatotoxicity is underreported and underestimated in the United States. It is an important cause of acute liver failure. Common classes of drugs causing drug-induced hepatotoxicity include antibiotics, lipid lowering agents, oral hypoglycemics, psychotropics, antiretrovirals, acetaminophen, and complementary and alternative medications ...
Ashutosh Barve +4 more
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Drug induced liver injury: an update
Archives of Toxicology, 2020Drug induced liver injury (DILI) is a relatively rare hepatic condition in response to the use of medications, illegal drugs, herbal products or dietary supplements. It occurs in susceptible individuals through a combination of genetic and environmental risk factors believed to modify drug metabolism and/or excretion leading to a cascade of cellular ...
Miren Garcia-Cortes +5 more
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Drug-Induced Liver Injury in the Elderly
Current Gastroenterology Reports, 2012Historically, the elderly have been considered to be at increased risk for drug-induced liver injury (DILI). Animal studies have demonstrated changes in hepatic physiology that affect drug metabolism in the aging liver; however, there is no evidence that this leads to any appreciable deterioration of liver function in healthy older humans. Updated data
James H. Lewis +2 more
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Drug-Induced Liver Injury [PDF]
, 1987 The manifold aspects of adverse hepatic drug reactions which have been frequently reviewed (Kaplowitz et al. 1986; Ludwig and Axelsen 1983; Popper et al. 1972; Strieker and Spoelstra 1985; Zimmerman 1978) include (a) pharmacology, based also on the chemical constitution of the drug, (b) mechanistics, dealing with the pathogenesis of the reaction, (c ...
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Drug-induced liver injury in pregnancy
Best Practice & Research Clinical Obstetrics & Gynaecology, 2020Drug intake in pregnant women is common, including prescribed and over-the-counter medications, and herbal medicine and supplements. Drug-induced liver injury (DILI) has become the leading cause of acute liver failure in Western countries, and pregnancy is thought to be a risk factor, but only few anecdotal reports concerning pregnant women are found ...
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The pathogenesis of drug-induced liver injury
Expert Review of Gastroenterology & Hepatology, 2016Drugs can induce liver injury when taken as an over-dose, or even at therapeutic doses in susceptible individuals. Although severe drug-induced liver injury (DILI) is a relatively uncommon clinical event, it is a potentially life threatening adverse drug reaction and is the most common indication for the drug withdrawal.
Sun-Jae Lee, Kwan-Kyu Park, Youn Ju Lee
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Veterinary Clinics of North America: Small Animal Practice
Drug-induced liver injury (DILI) is an underrecognized cause of hepatic disease in dogs and cats. Successful identification of cases requires an initial suspicion by the practitioner, a thorough drug exposure history, and knowledge of the toxic potential for common veterinary drugs.
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Drug-induced liver injury (DILI) is an underrecognized cause of hepatic disease in dogs and cats. Successful identification of cases requires an initial suspicion by the practitioner, a thorough drug exposure history, and knowledge of the toxic potential for common veterinary drugs.
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