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Biomarkers for drug-induced liver injury
Expert Review of Gastroenterology and Hepatology, 2010 Of the estimated 10,000 documented human drugs, more than 1000 have been associated with drug-induced liver injury (DILI), although causality has not always been established clearly. Numerous biomarkers for DILI have been explored, but less than ten are adopted or qualified as valid by the US FDA.
Qiang Shi, Huixiao Hong
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Drug‐induced Liver Injury in Pediatrics
Journal of Pediatric Gastroenterology and Nutrition, 2022Drug‐induced liver injury (DILI) is a rare, underdiagnosed cause of liver disease in children. The incidence of DILI in the pediatric population is unknown but it represents around 10% of all DILI cases. The most common hepatotoxic drugs in children are antibiotics and antiepileptics.
Fernanda, Monge-Urrea +1 more
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Current Opinion in Gastroenterology, 2012
Drug-induced liver injury (DILI) remains an important disease in clinical practice. It is difficult to predict, diagnose and manage. Studies in the peer-reviewed literature in the last 2 years, focusing on the diagnosis, prediction and management of DILI will be reviewed.Antibiotics remain the most common drug causing DILI in the United States and ...
Lafaine M, Grant, Don C, Rockey
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Drug-induced liver injury (DILI) remains an important disease in clinical practice. It is difficult to predict, diagnose and manage. Studies in the peer-reviewed literature in the last 2 years, focusing on the diagnosis, prediction and management of DILI will be reviewed.Antibiotics remain the most common drug causing DILI in the United States and ...
Lafaine M, Grant, Don C, Rockey
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Drug induced liver injury: an update
Archives of Toxicology, 2020Drug induced liver injury (DILI) is a relatively rare hepatic condition in response to the use of medications, illegal drugs, herbal products or dietary supplements. It occurs in susceptible individuals through a combination of genetic and environmental risk factors believed to modify drug metabolism and/or excretion leading to a cascade of cellular ...
Miren Garcia-Cortes +5 more
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Drug Safety, 2007
Drug-induced liver injury is a frequent cause of hepatic dysfunction. Reliably establishing whether the liver disease was caused by a drug requires the exclusion of other plausible causes and the search for a clinical drug signature. The drug signature consists of the pattern of liver test abnormality, the duration of latency to symptomatic ...
Gebran, Abboud, Neil, Kaplowitz
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Drug-induced liver injury is a frequent cause of hepatic dysfunction. Reliably establishing whether the liver disease was caused by a drug requires the exclusion of other plausible causes and the search for a clinical drug signature. The drug signature consists of the pattern of liver test abnormality, the duration of latency to symptomatic ...
Gebran, Abboud, Neil, Kaplowitz
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Mechanisms of Drug-induced Liver Injury [PDF]
Clinics in Liver Disease, 2013 Drug-induced liver injury (DILI) represents a broad spectrum of liver manifestations. However, the most common manifestation is hepatocyte death following drug intake. DILI can be predictable and dose dependent with a notable example of acetaminophen toxicity.
Liyun Yuan, Neil Kaplowitz
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2009
Many drugs and environmental chemicals are capable of evoking some degree of liver injury. The liver represents a primary target for adverse drug reactions due to its central role in biotransformation and excretion of foreign compounds, its portal location within the circulation exposing it to a wide variety of substances, and its anatomic and ...
Michael, Holt, Cynthia, Ju
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Many drugs and environmental chemicals are capable of evoking some degree of liver injury. The liver represents a primary target for adverse drug reactions due to its central role in biotransformation and excretion of foreign compounds, its portal location within the circulation exposing it to a wide variety of substances, and its anatomic and ...
Michael, Holt, Cynthia, Ju
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Drug-Induced Hepatotoxicity or Drug-Induced Liver Injury
Clinics in Liver Disease, 2009Drug-induced hepatotoxicity is underreported and underestimated in the United States. It is an important cause of acute liver failure. Common classes of drugs causing drug-induced hepatotoxicity include antibiotics, lipid lowering agents, oral hypoglycemics, psychotropics, antiretrovirals, acetaminophen, and complementary and alternative medications ...
Aaron J, Pugh +4 more
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Signatures in drug-induced liver injury
Current Opinion in Gastroenterology, 2020Purpose of review Drug-induced liver injury (DILI) can be induced by a myriad of drugs. Assessing whether the patient has DILI and assessing which drug is the most likely culprit are challenging. There has been too little attention paid to the concept that certain drugs appear to have unique clinical features or ‘phenotypes’.
Hans L, Tillmann, Don C, Rockey
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Drug-induced liver injury in children
Current Opinion in Pediatrics, 2015Drug-induced liver injury (DILI) is an underrecognized cause of pediatric liver disease, accounts for almost 20% of pediatric acute liver failure cases, and is a major reason for liver transplantation in the USA. This article reviews the pathogenesis of DILI, approach to diagnosis and management, and highlights recent pediatric DILI case series.Select ...
Mansi D, Amin +2 more
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