Results 21 to 30 of about 400,521 (193)
The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury. [PDF]
, 2010 The pregnane X receptor (PXR) is a nuclear receptor transcription factor regulating drug-metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic detoxification.
Damjanov, Ivan +2 more
core +6 more sources
Drug-Induced Liver Injury [PDF]
Clinical Infectious Diseases, 2004 Drug-induced hepatotoxicity is a frequent cause of liver injury. The predominant clinical presentation is acute hepatitis and/or cholestasis, although almost any clinical pathological pattern of acute or chronic liver disease can occur. The pathogenesis of drug-induced liver disease usually involves the participation of the parent drug or metabolites ...
openaire +2 more sources
Materials Today Bio, 2023 Herein, an activable fluorescent probe for peroxynitrite (ONOO−), named NOP, was constructed for the accurate imaging in the processes of formation and inhibition of drug-induced liver injury induced by Acetaminophen (APAP).
Junming Dong +4 more
doaj +1 more source
Diagnosis of drug induced liver injury using a lymphocyte blast transformation test based on whole blood culture [PDF]
, 1977 Twenty cases of suspected drug induced liver injury (16 cases of which satisfied the criteria for at least a query positive diagnosis as based on the Fourth Congress of "Drugs and the Liver" in Japan) were studied by the whole blood culture ...
Takata, Shinji
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Annals of Internal Medicine: Clinical Cases, 2023 Drug-induced liver injury is a common cause of liver damage, with antimicrobial use as the leading cause. Although most patients recover after discontinuing the offending agent, severe cases may result in progressive disease or death, requiring liver ...
Makeda Dawkins +5 more
doaj +1 more source
Rivaroxaban-induced hepatotoxicity: review of the literature and report of new cases [PDF]
, 2018 Aim/Objective/Background Direct-acting oral anticoagulant drugs are marketed worldwide for the primary and secondary prevention and treatment of thromboembolic disorders.
Almasio, Pier Luigi +9 more
core +1 more source
Albendazole-induced granulomatous hepatitis: a case report [PDF]
, 2013 INTRODUCTION: Drug-related hepatotoxicity is a common medical problem with implications for health systems. It constitutes a cause of acute liver failure and, in many cases, is responsible for the rejection of new pharmacological agents during efficacy ...
Andres Eduardo Marin Castro +3 more
core +1 more source
Pharmacogenetics of drug‐induced liver injury† [PDF]
Hepatology, 2010 Recent progress in research on drug-induced liver injury (DILI) has been determined by key developments in two areas. First, new technologies allow the identification of genetic risk factors with improved sensitivity, specificity, and efficiency.
Russmann Stefan +2 more
openaire +3 more sources
Genetic polymorphisms of interleukin-10 and transforming growth factor-β1 and antituberculosis drugs-induced liver injury [PDF]
, 2017 Purpose: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of med ications. Previously, IL-10 gene polymorphism has been reported to be associated with diclofenac-induced hepatitis.
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core +1 more source
Tuberculosis Drug-Induced Liver Injury
Jurnal Respirasi, 2020 Effective tuberculosis (TB) treatment requires a combination of bactericidal and/or bacteriostatic TB drugs. The combination of these regimens is the standard therapy recommended by World Health Organization (WHO).
Soedarsono Soedarsono +1 more
doaj +1 more source