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Drug-Induced Liver Injury [PDF]
Mayo Clinic Proceedings, 2014 Drug hepatoxicity can be nonidiosyncratic (predictable), as in the case of acetaminophen, or idiosyncratic (unpredictable). This review article focuses primarily on idiosyncratic drug-induced liver injury (DILI). New epidemiologic data suggest that approximately 20 new cases of DILI per 100,000 persons occur each year.
Michael D. Leise +2 more
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Archives of Pathology & Laboratory Medicine, 2015 ContextDrug-induced liver injury (DILI) represents a diverse set of responses following exposure to any manufactured or naturally occurring chemical compound. Drug-induced liver injury is of major concern owing to the ever increasing number of compounds introduced into the market for treatment of various diseases as well as the increasing popularity of
Raj Vuppalanchi +2 more
+7 more sources
Pharmacogenetics of drug‐induced liver injury† [PDF]
Hepatology, 2010 Recent progress in research on drug-induced liver injury (DILI) has been determined by key developments in two areas. First, new technologies allow the identification of genetic risk factors with improved sensitivity, specificity, and efficiency.
Russmann Stefan +2 more
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Drug Hepatotoxicity: Environmental Factors [PDF]
, 2017 Drug-induced liver injury presents as various forms of acute and chronic liver disease. There is wide geographic variation in the most commonly implicated agents.
Chalasani, Naga P., Stine, Jonathan G.
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Diagnosis of drug induced liver injury using a lymphocyte blast transformation test based on whole blood culture [PDF]
, 1977 Twenty cases of suspected drug induced liver injury (16 cases of which satisfied the criteria for at least a query positive diagnosis as based on the Fourth Congress of "Drugs and the Liver" in Japan) were studied by the whole blood culture ...
Takata, Shinji
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A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury [PDF]
, 2019 BACKGROUND & AIMS: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility.
Cirulli, Elizabeth T. +4 more
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Drug-Induced Liver Injury [PDF]
Clinical Infectious Diseases, 2004 Drug-induced hepatotoxicity is a frequent cause of liver injury. The predominant clinical presentation is acute hepatitis and/or cholestasis, although almost any clinical pathological pattern of acute or chronic liver disease can occur. The pathogenesis of drug-induced liver disease usually involves the participation of the parent drug or metabolites ...
openaire +3 more sources
Rivaroxaban-induced hepatotoxicity: review of the literature and report of new cases [PDF]
, 2018 Aim/Objective/Background Direct-acting oral anticoagulant drugs are marketed worldwide for the primary and secondary prevention and treatment of thromboembolic disorders.
Almasio, Pier Luigi +9 more
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Genetic polymorphisms of interleukin-10 and transforming growth factor-β1 and antituberculosis drugs-induced liver injury [PDF]
, 2017 Purpose: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of med ications. Previously, IL-10 gene polymorphism has been reported to be associated with diclofenac-induced hepatitis.
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Albendazole-induced granulomatous hepatitis: a case report [PDF]
, 2013 INTRODUCTION: Drug-related hepatotoxicity is a common medical problem with implications for health systems. It constitutes a cause of acute liver failure and, in many cases, is responsible for the rejection of new pharmacological agents during efficacy ...
Andres Eduardo Marin Castro +3 more
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