Results 31 to 40 of about 287,075 (253)
Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review
Frontiers in Pharmacology, 2022 Introduction: Apart from cessation of the implicated agent leading to drug-induced liver injury (DILI), there is no standard therapy for DILI. Corticosteroids have been used in DILI, although their efficacy is unclear.
E. Björnsson +3 more
semanticscholar +1 more source
Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges
International Journal of Molecular Sciences, 2021 Idiosyncratic drug-induced liver injury (IDILI) remains a significant problem for patients and drug development. The idiosyncratic nature of IDILI makes mechanistic studies difficult, and little is known of its pathogenesis for certain.
A. Jee, S. Sernoskie, J. Uetrecht
semanticscholar +1 more source
Fluorescent probe for the imaging of superoxide and peroxynitrite during drug-induced liver injury†
Chemical Science, 2021 Drug-induced liver injury (DILI) is an important cause of potentially fatal liver disease. Herein, we report the development of a molecular probe (LW-OTf) for the detection and imaging of two biomarkers involved in DILI.
Luling Wu +7 more
semanticscholar +1 more source
Characterization of Frequency-Dependent Material Properties of Human Liver and its Pathologies Using an Impact Hammer [PDF]
Medical Image Analysis, 2011, Vol. 15, No.1, pp. 45-52, 2021 The current methods for characterization of frequency-dependent material properties of human liver are very limited. In fact, there is almost no data available in the literature showing the variation in dynamic elastic modulus of healthy or diseased human liver as a function of excitation frequency.
arxiv +1 more source
Incidence and Etiology of Drug-Induced Liver Injury in Mainland China.
Gastroenterology, 2019 BACKGROUND & AIMS We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China.
T. Shen +29 more
semanticscholar +1 more source
High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids.
Gastroenterology, 2020 BACKGROUND & AIMS Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a need for a predictive human system to study complicated DILI mechanism and ...
T. Shinozawa +15 more
semanticscholar +1 more source
Drug-Induced Liver Injury: Highlights and Controversies in the Recent Literature
Drug Safety, 2021 Drug-induced liver injury (DILI) remains an important, yet challenging diagnosis for physicians. Each year, additional drugs are implicated in DILI and this year was no different, with more than 1400 articles published on the subject.
J. Clinton +5 more
semanticscholar +1 more source
MicroRNAs in Drug-induced Liver Injury [PDF]
Journal of Clinical and Translational Hepatology, 2014 Drug-induced liver injury (DILI) is a leading cause of acute liver failure, and a major reason for the recall of marketed drugs. Detection of potential liver injury is a challenge for clinical management and preclinical drug safety studies, as well as a great obstacle to the development of new, effective and safe drugs.
Ke Zen, Dong Wang, Limin Li
openaire +2 more sources
Drug-Induced Liver Injuries (Clinical Guidelines for Physicians)
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2019 Aim. Clinical guidelines for the management of adult patients suffering from drug-induced liver injuries (DILI) are intended for all medical specialists, who treat such patients in their clinical practice.Key findings.
Vladimir T. Ivashkin +8 more
doaj +1 more source
Tuberculosis Drug-Induced Liver Injury
Jurnal Respirasi, 2020 Effective tuberculosis (TB) treatment requires a combination of bactericidal and/or bacteriostatic TB drugs. The combination of these regimens is the standard therapy recommended by World Health Organization (WHO).
Soedarsono Soedarsono +1 more
doaj +1 more source