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International Journal of Molecular Sciences, 2022 One of the major mechanisms of drug-induced liver injury includes mitochondrial perturbation and dysfunction. This is not a surprise, given that mitochondria are essential organelles in most cells, which are responsible for energy homeostasis and the ...
M. Mihajlovic, M. Vinken
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Drug-Induced Liver Injury [PDF]
Clinical Infectious Diseases, 2004 Drug-induced hepatotoxicity is a frequent cause of liver injury. The predominant clinical presentation is acute hepatitis and/or cholestasis, although almost any clinical pathological pattern of acute or chronic liver disease can occur. The pathogenesis of drug-induced liver disease usually involves the participation of the parent drug or metabolites ...
openaire +2 more sources
Incidence and Etiology of Drug-Induced Liver Injury in Mainland China.
Gastroenterology, 2019 BACKGROUND & AIMS We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China.
T. Shen +29 more
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Pharmacotherapies for Drug-Induced Liver Injury: A Current Literature Review
Frontiers in Pharmacology, 2022 Drug-induced liver injury (DILI) has become a serious public health problem. For the management of DILI, discontinuation of suspicious drug or medicine is the first step, but the treatments including drugs and supporting approaches are needed.
Meng Li +4 more
semanticscholar +1 more source
Annals of Internal Medicine: Clinical Cases, 2023 Drug-induced liver injury is a common cause of liver damage, with antimicrobial use as the leading cause. Although most patients recover after discontinuing the offending agent, severe cases may result in progressive disease or death, requiring liver ...
Makeda Dawkins +5 more
doaj +1 more source
Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges
International Journal of Molecular Sciences, 2021 Idiosyncratic drug-induced liver injury (IDILI) remains a significant problem for patients and drug development. The idiosyncratic nature of IDILI makes mechanistic studies difficult, and little is known of its pathogenesis for certain.
A. Jee, S. Sernoskie, J. Uetrecht
semanticscholar +1 more source
Rivaroxaban-induced hepatotoxicity: review of the literature and report of new cases [PDF]
, 2018 Aim/Objective/Background Direct-acting oral anticoagulant drugs are marketed worldwide for the primary and secondary prevention and treatment of thromboembolic disorders.
Almasio, Pier Luigi +9 more
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Albendazole-induced granulomatous hepatitis: a case report [PDF]
, 2013 INTRODUCTION: Drug-related hepatotoxicity is a common medical problem with implications for health systems. It constitutes a cause of acute liver failure and, in many cases, is responsible for the rejection of new pharmacological agents during efficacy ...
Andres Eduardo Marin Castro +3 more
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Diagnosis of drug induced liver injury using a lymphocyte blast transformation test based on whole blood culture [PDF]
, 1977 Twenty cases of suspected drug induced liver injury (16 cases of which satisfied the criteria for at least a query positive diagnosis as based on the Fourth Congress of "Drugs and the Liver" in Japan) were studied by the whole blood culture ...
Takata, Shinji
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Pharmacogenetics of drug‐induced liver injury† [PDF]
Hepatology, 2010 Recent progress in research on drug-induced liver injury (DILI) has been determined by key developments in two areas. First, new technologies allow the identification of genetic risk factors with improved sensitivity, specificity, and efficiency.
Russmann Stefan +2 more
openaire +3 more sources