Results 111 to 120 of about 12,201 (250)

Model-based identification of TNF alpha-induced IKK beta-mediated and I kappa B alpha-mediated regulation of NF kappa B signal transduction as a tool to quantify the impact of drug-induced liver injury compounds [PDF]

, 2018
Drug-induced liver injury: mathematical model quantifies impact of liver-damaging drugs Drug-induced liver injury (DILI) is one of the most important obstacles during drug development.
Buck-Wiese, Marie, Goldring, Christopher E, Heilemann, Mike, Herrmann, Franziska, Huppelschoten, Suzanna, Jones, Robert P, Kaschek, Daniel, Klingmueuler, Ursula, Kruger, Carmen L, Malik, Hassan, Malkusch, Sebastian, Merkt, Benjamin, Meub, Mara, Oppelt, Angela, Park, B Kevin, Schilling, Marcel, Schofield, Amy, Sison-Young, Rowena, Timmer, Jens, van de Water, Bob, Zhang, Fang, Zimmermann, Lea   +21 more
core   +2 more sources

Could Sigmoid Diverticulitis, Drug-Induced Liver Injury, and Drug-Induced Pancreatitis Co-occur? [PDF]

Sigmoid diverticulitis is a leading cause of gastrointestinal pathology etiology, which causes hospital admissions in Western society. Recent studies have shown its prevalence to be 1-4%. Drug-induced liver injury (DILI) is a primary cause of acute liver
Alweis, Richard, Labuzetta, Michael, Sharma, Rutwik Pradeep, Tam, Ryan   +3 more
core   +2 more sources

Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance [PDF]

, 2017
Background & AimsDrug induced liver injury (DILI) is challenging because of the lack of biomarkers to predict mortality. Our aim was to describe miRNA changes in sera of subjects with acute idiosyncratic DILI and determine if levels of miRNAs were ...
Anderson, William E., Bonkovsky, Herbert L., Chalasani, Naga, Fontana, Robert J., Foureau, David, Norton, Harry J., Russo, Mark W., Serrano, Jose, Steuerwald, Nury, Watkins, Paul B.   +9 more
core   +1 more source

The transformation in biomarker detection and management of drug-induced liver injury [PDF]

, 2017
Drug-induced liver injury (DILI) is a major concern for patients, care givers and the pharmaceutical industry. Interpretation of the serum biomarkers routinely used to detect and monitor DILI, which have not changed in almost 50 years, can be improved ...
Church, Rachel J., Watkins, Paul B.
core   +2 more sources

Mechanistic insights into antiretroviral drug‐induced liver injury

Pharmacology Research & Perspectives, 2020
All classes of antiretroviral therapy (ART) have been implicated to induce adverse drug reactions such drug‐induced liver injury (DILI) and immune‐mediated adverse reactions in Human Immunodeficiency Virus (HIV) infected individuals.
Jamie N. Pillaye, Mohlopheni J. Marakalala, Nonhlanhla Khumalo, Wendy Spearman, Hlumani Ndlovu   +4 more
doaj   +1 more source

Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options [PDF]

, 2015
Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI may be indistinguishable from ...
Ariel A. Benson, Ayman Abu Rmeilehx, Liron Yosha, Meir Mizrahix, Saleh Daher, Tawfik Khouryx, Translational Hepatology   +6 more
core   +2 more sources

Establishing reference ranges for circulating biomarkers of drug‐induced liver injury in healthy human volunteers1

British Journal of Clinical Pharmacology, EarlyView.
Aims The potential of mechanistic biomarkers to improve prediction of drug‐induced liver injury (DILI) and hepatic regeneration is widely acknowledged. We sought to determine reference intervals for new biomarkers of DILI and regeneration, as well as to characterize their natural variability and impact of diurnal variation.
Andrea L. Jorgensen, Samantha Korver, Amy Schofield, Lawrence Howell, Joanna I. Clarke, Lauren E. Walker, Nathalie Brillant, Chris E. P. Goldring, Munir Pirmohamed   +8 more
wiley   +1 more source

Drug-induced liver injury [PDF]

, 2016
Oštećenje jetre uzrokovano lijekovima ( engl. Drug-Induced Liver Damage, DILI) objedinjuje niz kliničkih slika, od asimptomatskih slučajeva povišenja jetrenih enzima, do teških slučajeva akutnog ili kroničnog oštećenja jetre koji rezultiraju zatajenjem ...
Lukša, Lea
core   +6 more sources

Acute Liver Failure Due to Etodolac, a Selective Cycloxygenase- 2 (COX -2) Inhibitor Non-Steroidal Anti-Inflammatory Drug Established by RUCAM-Based Causality Assessment

Annals of Hepatology, 2017
Drug induced liver injury is a common cause of acute liver failure (ALF). While most of these cases are due to dose dependent hepa-totoxicity with acetaminophen, idiosyncratic drug-induced liver injury (DILI) is responsible for about 15% cases of ALF ...
Sunil Taneja, Pramod Kumar, Sahaj Rathi, Ajay Duseja, Virendra Singh, Radha Krishan Dhiman, Yogesh Kumar Chawla   +6 more
doaj  

Stochastic Ordering under Conditional Modelling of Extreme Values: Drug-Induced Liver Injury [PDF]

arXiv, 2012
Drug-induced liver injury (DILI) is a major public health issue and of serious concern for the pharmaceutical industry. Early detection of signs of a drug's potential for DILI is vital for pharmaceutical companies' evaluation of new drugs. A combination of extreme values of liver specific variables indicate potential DILI (Hy's Law).
arxiv