Results 111 to 120 of about 12,367 (201)

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis [PDF]

, 2016
Although necrosis and necroinflammation are central features of many liver diseases, the role of programmed necrosis in the context of inflammation-dependent hepatocellular death remains to be fully determined.
Andreas E. Kremer, Andreas Linkermann, Babon, Cai, Christin Dewitz, Christoph Becker, Christopher Poremba, Claudia Günther, Deutsch, Dusheiko, Emma J. Petrie, Gui-Wei He, James M. Murphy, Kang, Kerstin Amann, Ma, Manns, Marinescu, Markus F. Neurath, Peter Vandenabeele, Pine, Siebler, Stefan Krautwald, Stefan Wirtz, Ulrike Schleicher   +24 more
core   +1 more source

Charakterisierung der Chemikalien-induzierten Leberschädigung („Drug-Induced Liver Injury“ – DILI)

, 2017
The aim of the presented PhD thesis was the development of a new in vitro test system which allows for a better characterization and prediction of drug- induced liver injuries (DILI). After the initial damage of hepatocytes, the activation of the immune system can aggravate this damage and lead to severe liver failure. This important interaction should
openaire   +2 more sources

Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing. [PDF]

Pharmaceutics, 2022
Tátrai P, Erdő F, Krajcsi P.
europepmc   +1 more source

A brief overview of drug-induced liver damage

The Egyptian Journal of Internal Medicine
Drug-induced liver injury (DILI) is a prevalent disorder that can be led on by almost all drug types. The majority of benign DILI cases become better after drug discontinuation.
Soumyadip Roy, Zalak Shah, G. S. Chakraborthy   +2 more
doaj   +1 more source

Helicobacter pylori Eradication Therapy–Associated Drug-Induced Liver Injury in a Patient With Primary Biliary Cholangitis

Gastro Hep Advances
Drug-induced liver injury (DILI) is a rare but serious complication of Helicobacter pylori eradication therapy, especially in patients with pre-existing liver disease. We report a 75-year-old man with well-controlled primary biliary cholangitis (PBC) who
Taro Nakajima, Takefumi Kimura, Yuki Yamashita, Yugo Iwaya, Tadanobu Nagaya, Hiromitsu Mori, Shuichi Wada   +6 more
doaj   +1 more source

EGCG inhibits ferroptosis to ameliorate APAP-induced liver injury by suppressing NEDD8 and stabilizing HUWE1 in vivo and in vitro

Acta Materia Medica
Excessive consumption of acetaminophen (APAP) has emerged as the primary culprit behind drug-induced liver injury (DILI), with N-acetylcysteine serving as the principal antidote.
Zijun Ouyang, Tao Zhang, Mengting Liu, Fufu Li, Hui Guo, Yanhui Li, Jieyu Chen, Feiyang Wang, Yang Sun, Dong Liu, Haiyan Sun   +10 more
doaj   +1 more source

Exploring drug-induced liver injury: comprehensive insights into mechanisms and management of hepatotoxic agents

Future Journal of Pharmaceutical Sciences
Background Drug-induced liver injury (DILI) is a significant adverse drug reaction, manifesting through a range of clinical presentations from mild liver enzyme to acute liver failure.
Ahmed K. Saleh, Thanaa A. El-Masry, Aya H. El-Kadem, Nada A. Ashour, Nageh A. El-Mahdy   +4 more
doaj   +1 more source

Drug induced liver injury (DILI) causes: Literatur review

Annals of Hepato-Biliary-Pancreatic Surgery, 2022
openaire   +1 more source

Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI). [PDF]

Frontline Gastroenterol, 2022
Brennan PN, Cartlidge P, Manship T, Dillon JF.   +3 more
europepmc   +1 more source

Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI). [PDF]

PLoS Comput Biol, 2022
Liu A, Han N, Munoz-Muriedas J, Bender A.   +3 more
europepmc   +1 more source