Results 111 to 120 of about 964 (152)

Development of A Battery of In Silico Prediction Tools for Drug-Induced Liver Injury (DILI) from the Vantage Point of Translational Safety Assessment [PDF]

, 2020
James F. Rathman, Chihae Yang, Vinnie Ribeiro, Aleksandra Mostrąg, Shraddha Thakkar, Weida Tong, Bryan Hobocienski, Oliver Sacher, Tomasz Magdziarz, Bruno Bienfait   +9 more
openalex   +1 more source

DRUG-INDUCED LIVER INJURY-DILI AND HILI IN CLINICAL PRACTICE

Drug-induced liver damage is still a problem for modern medicine. On the one hand, it is related tothe polyprogression found mainly in the elderly and chronically ill, and on the other hand, to thefashion for young people to use dietary supplements and herbs. The course of DILI can range froma mild, asymptomatic, reversible increase in liver parameters
Rajewski, Paweł, Jakub, Cieściński, Piotr, Rajewski   +2 more
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Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury

Advanced Science
Obesity and nonalcoholic fatty liver disease (NAFLD) are established risk factors for drug‐induced liver injury (DILI). The previous study demonstrates that benzbromarone (BBR), a commonly prescribed pharmaceutical agent for managing gout and ...
Guanting Li, Yourong Hu, Han Zhao, Ziyu Peng, Xin Shang, Jia Zhang, Kunxin Xie, Meiwei Li, Xiaohang Zhou, Qinyao Zhou, Kai Li, Fang Zhou, Heyao Wang, Zhijian Xu, Jiali Liu, Peng Sun   +15 more
doaj   +1 more source

Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanisticin vitroAssays [PDF]

, 2015
Falgun Shah, Louis Leung, Hugh A. Barton, Yvonne Will, A. David Rodrigues, Nigel Greene, Michael D. Aleo   +6 more
openalex   +1 more source

Dyslipidemia is a Risk Factor for the Incidence and Severity of Drug-Induced Liver Injury (DILI): A Retrospective Population-Based Study in China [PDF]

, 2019
Li Xu, Le Wang, Dezhao Li, Junqi Niu, Pujun Gao   +4 more
openalex   +1 more source

Drug-Induced Liver Injury in the Elderly: Consensus Statements and Recommendations from the IQ-DILI Initiative [PDF]

Eric Cohen, Meenal Patwardhan, Ritu Raheja, David Alpers, Raúl J. Andrade, Mark Avigan, James H. Lewis, Don C. Rockey, Francis Chui, Alexandru M. Iacob, Camila C.G. Linardi, Arie Regev, Jesse Shick, M. Isabel Lucena   +13 more
openalex   +1 more source

A novel phenotype‐based drug‐induced liver injury causality assessment tool (DILI‐CAT) allows for signal confirmation in early drug development [PDF]

, 2022
Richard Hermann, Don C. Rockey, Ayako Suzuki, Michael Merz, Hans L. Tillmann   +4 more
openalex   +1 more source

pDILI_v1: A Web-Based Machine Learning Tool for Predicting Drug-Induced Liver Injury (DILI) Integrating Chemical Space Analysis and Molecular Fingerprints [PDF]

Sk. Abdul Amin, Supratik Kar, Stefano Piotto   +2 more
openalex   +1 more source

Charakterisierung der Chemikalien-induzierten Leberschädigung („Drug-Induced Liver Injury“ – DILI)

, 2017
The aim of the presented PhD thesis was the development of a new in vitro test system which allows for a better characterization and prediction of drug- induced liver injuries (DILI). After the initial damage of hepatocytes, the activation of the immune system can aggravate this damage and lead to severe liver failure. This important interaction should
openaire   +2 more sources

S1202 Drug-Induced Liver Injury (DILI) Ascribed to Non-Steroidal Anti-inflammatory Drugs (NSAIDs) in the USA: An Update With Genetic Correlations From the U.S. Drug-Induced Liver Injury Network (DILIN)

, 2022
Herbert L. Bonkovsky, Marwan Ghabril, Paola Nicoletti, Jiezhun Gu, Robert J. Fontana, David E. Kleiner, Huiman X. Barnhart   +6 more
openalex   +1 more source