Results 121 to 130 of about 12,201 (250)

Hepatitis E Virus Detection in Liver Tissue from Patients with Suspected Drug-Induced Liver Injury [PDF]

, 2015
Hepatitis E virus (HEV) infection is increasingly recognized as a cause of acute hepatitis in the industrialized world. We aimed to determine the frequency of acute Hepatitis E virus (HEV) infection in cases of suspected drug-induced liver injury (DILI),
Achim Weber, Erik Springer, Marion Bawohl, Obinna Chijioke   +3 more
core   +2 more sources

Genetic Connection to Drug-Induced Liver Injury (DILI) Through Statistical Learning Methods [PDF]

, 2021
R. E. Moore, Kristin McEuen
openalex   +1 more source

Standardization of nomenclature and causality assessment in drug-induced liver injury: Summary of a clinical research workshop [PDF]

, 2010
Idiosyncratic drug-induced liver injury (DILI) is an important but relatively infrequent cause of potentially severe acute and chronic liver injury.
Aithal, Aithal, Andrade, Arimone, Begaud, Benichou, Bjornsson, Chalasani, Daly, Danan, de Abajo, De Valle, Dreifuss, Fontana, Furhoff, Galan, Garcia-Cortes, Hamer, Heubi, Hughes, Kim, Kleiner, Lee, Lucena, Lucena, Maria, Masumoto, McFarland, Meier, Murray, Naranjo, Ostapowicz, Pande, Papay, Rochon, Rockey, Sgro, Sharp, Sulkowski, Takikawa, Takikawa, Temple, Tsong, Vuppalanchi, Vuppalanchi, Wai, Watkins, Whiting-O'Keefe, Wong   +48 more
core   +1 more source

Nationwide survey of patients with acute liver failure and late‐onset hepatic failure in Japan seen between 2016 and 2021

Hepatology Research, EarlyView.
Abstract Aim A nationwide survey was conducted to clarify the recent status of patients with acute liver failure (ALF) and late‐onset fulminant hepatitis (LOHF) in Japan. Methods Two‐step surveys were performed annually targeting 782 hospitals, focusing on patients meeting the Japanese diagnostic criteria.
Nobuaki Nakayama, Masamitsu Nakao, Yoshihito Uchida, Akio Ido, Yasuhiro Takikawa, Keisuke Kakisaka, Naoya Kato, Kazuaki Chayama, Kazuaki Inoue, Mureo Kasahara, Shuji Terai, Hiromasa Ohira, Isao Sakaida, Taro Takami, Kiyoshi Hasegawa, Masanori Abe, Masahito Shimizu, Hitoshi Yoshiji, Takuya Genda, Ayano Inui, Ryuzo Abe, Hajime Takikawa, Atsushi Tanaka, Satoshi Mochida   +23 more
wiley   +1 more source

Drug Induced Liver Injury (Dili) and Non Alcoholic Fatty Liver Disease (Nafld)

European Journal of Medical and Health Sciences, 2020
This review article includes a review of the latest literature searched on PubMed in the field of hepatotoxicity caused by drugs that have a wide daily application. The concept of the review article consists of several parts dealing with the definition of drugs induced liver injury - DILI, diagnostic challenges related to it, and the clinical spectrum ...
Nikola Malešević, Zoran Mavija, Anna Licata, Goran Bokan   +3 more
openaire   +3 more sources

Drug‐induced cholestasis

Hepatology Communications, 2017
Cholestatic drug‐induced liver injury (DILI) can be a diagnostic challenge due to a large differential diagnosis, variability in clinical presentation, and lack of serologic biomarkers associated with this condition.
Vinay Sundaram, Einar S. Björnsson
doaj   +1 more source

Causality Assessment for Suspected DILI During Clinical Phases of Drug Development [PDF]

, 2014
Causality assessment is a critical step in establishing the diagnosis of drug induced liver injury (DILI) during drug development. DILI may resemble almost any type of liver disease, and often presents a serious challenge to clinical investigators and ...
Aithal, Guruprasad P., Gallivan, Jim, Merz, Michael, Ormarsdottir, Sif, Regev, Arie, Seeff, Leonard B., Watkins, Paul B.   +6 more
core   +2 more sources

Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub‐Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1338-1357, May 2025.
Tuberculosis (TB) is a major health burden in Africa. Although TB is treatable, anti‐TB drugs are associated with adverse drug reactions (ADRs), which are partly attributed to pharmacogenetic variation. The distribution of star alleles (haplotypes) influencing anti‐TB drug metabolism is unknown in many African populations.
Thandeka V.B. Malinga, Houcemeddine Othman, Maria Paximadis, Caroline T. Tiemessen, Michèle Ramsay, Scott Hazelhurst, David Twesigomwe   +6 more
wiley   +1 more source

Immunology Highlights of Four Major Idiosyncratic DILI Subtypes Verified by the RUCAM: A New Evidence-Based Classification

Livers
Conventionally, drug-induced liver injury (DILI) exists in two types: idiosyncratic and intrinsic. Both types are classified as non-immune disorders, thereby ignoring that some iDILI cases may have an immune or autoimmune background that requires a ...
Rolf Teschke
doaj   +1 more source

Drug Liver Injury Induced by Olmesartan Mediated by Autoimmune-Like Mechanism: A Case Report

European Journal of Case Reports in Internal Medicine, 2020
Autoimmune hepatitis (AIH) was the first liver disease for which an effective therapeutic intervention was carried out, using prednisolone; its usefulness was demonstrated in several clinical trials.
Manuel de la Torre-Aláez, Mercedes Iñarrairaegui   +1 more
doaj   +1 more source