Results 121 to 130 of about 12,091 (224)

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]

, 2011
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen, Manuela G. Neuman, Paul A. Hwang, Radu M. Nanau   +3 more
core   +1 more source

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity [PDF]

, 2009
Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to inadequacy of current preclinical screening assays, but recently established rodent models utilizing bacterial LPS co-administration to induce an inflammatory ...
Bart S. Hendriks, Bellezzo, Benjamin D. Cosgrove, Bergheim, Box, Bracken M. King, Bruce Tidor, Buchweitz, Clay, Clayton, Cosgrove, Deng, Deng, Domansky, Douglas A. Lauffenburger, Ganey, Geller, Gomez-Lechon, Hewitt, Hoek, Horn, Hwa, Jinghai J. Xu, Kaplowitz, Kaplowitz, LeCluyse, Lee, Leonidas G. Alexopoulos, Linda G. Griffith, Liu, Luedde, Luyendyk, Malhi, Mari, Maya A. Hasan, O'Brien, Obach, Olson, Ostapowicz, Paraskevi A. Farazi, Peter K. Sorger, Peters, Schwabe, Shaw, Shaw, Sivaraman, Tacke, Trusheim, Tukov, Tukov, Uetrecht, Uetrecht, Uetrecht, Warren, Wu, Xu, Xu, Zolfaghari   +57 more
core   +1 more source

Rapid‐Onset Drug‐Induced Liver Injury Following Amoxicillin‐Clavulanate: A Case Report

Clinical Case Reports
Drug‐Induced Liver Injury (DILI) is a rare but potentially serious adverse effect of many commonly used medications. DILI is a diagnosis of exclusion and requires a high index of suspicion.
Shuvam Khadka, Abinash Dev, Pramodman Singh Yadav, Sujan Acharya, Amisha Karki, Leeza Shah   +5 more
doaj   +1 more source

Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]

, 2019
High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul, Khambu, Bilon, Yan, Shengmin, Yin, Xiao-Ming   +3 more
core   +1 more source

The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report

Frontiers in Pharmacology
Idiosyncratic hepatotoxicity is a type of drug-induced liver injury (DILI) that is unpredictable and clinically severe, and amoxicillin clavulanate (AC) is the most implicated drug in DILI worldwide. The clinical manifestations of amoxicillin clavulanate-
Yan Zhan, Yan Zhan, Yan Zhan, Yan Zhan, Jin-Mao Liao, Ling Ye, Ling Ye, Ling Ye, Ling Ye, Long Zhang, Long Zhang, Long Zhang, Long Zhang, Long Zhang, Zheng Zhang, Ji-Ye Yin, Ji-Ye Yin, Ji-Ye Yin, Ji-Ye Yin   +18 more
doaj   +1 more source

Research progress of mitochondrial dysfunction in drug-induced liver injury [PDF]

Yixue xinzhi zazhi
Drug-induced liver injury (DILI) is a type of drug-induced liver injury with complex and diverse mechanisms that can lead to liver failure in severe cases, thereby affecting patients' quality of life and survival.
SUN Huijuan, HU Wenkai, LIU Shumin
doaj   +1 more source

Drug-induced liver injury. Part I: Classification, diagnosis and treatment

Clinical & Experimental Hepatology
Drug-induced liver injury (DILI) is a growing clinical problem. Antibiotics remain the most common cause of DILI in Europe. Their clinical spectrum is very broad, from asymptomatic to acute liver failure. Currently, DILI is categorized as hepatocellular (
Dorota M. Kozielewicz, Piotr Stalke, Julita Skrzypek   +2 more
doaj   +1 more source

Charakterisierung der Chemikalien-induzierten Leberschädigung („Drug-Induced Liver Injury“ – DILI)

, 2017
The aim of the presented PhD thesis was the development of a new in vitro test system which allows for a better characterization and prediction of drug- induced liver injuries (DILI). After the initial damage of hepatocytes, the activation of the immune system can aggravate this damage and lead to severe liver failure. This important interaction should
openaire   +2 more sources

Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing. [PDF]

Pharmaceutics, 2022
Tátrai P, Erdő F, Krajcsi P.
europepmc   +1 more source

A brief overview of drug-induced liver damage

The Egyptian Journal of Internal Medicine
Drug-induced liver injury (DILI) is a prevalent disorder that can be led on by almost all drug types. The majority of benign DILI cases become better after drug discontinuation.
Soumyadip Roy, Zalak Shah, G. S. Chakraborthy   +2 more
doaj   +1 more source