Results 141 to 150 of about 11,641 (246)

Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug‐Induced Liver Injury in the Spanish DILI Registry [PDF]

, 2020
Judith Sanabria‐Cabrera, Rocío Sanjuán‐Jiménez, Encarnación Clavijo, Inmaculada Medina‐Cáliz, A. González-Jiménez, Miren García‐Cortés, Aida Ortega‐Alonso, Miguel Jiménez‐Pérez, Rocío González‐Grande, Camilla Stephens, Mercedes Robles‐Díaz, M. Isabel Lucena, Raúl J. Andrade   +12 more
openalex   +1 more source

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. [PDF]

, 2017
Assessing the potential of a new drug to cause drug-induced liver injury (DILI) is a challenge for the pharmaceutical industry. We therefore determined whether cell models currently used in safety assessment (HepG2, HepaRG, Upcyte and primary human ...
Aerts, H, Alexandre, E, Antherieu, S, Dorau, M, Elmasry, M, Gerets, HHJ, Goldring, CE, Hewitt, PG, Holder, JC, Hoët, D, Ingelman-Sundberg, M, Johann, E, Jones, RP, Kitteringham, NR, Labbe, G, Lauschke, VM, Lovatt, CA, Park, BK, Richert, L, Schofield, CA, Sison-Young, RL, Stahl, SH, Weaver, RJ   +22 more
core   +1 more source

Role of Gut Microecology in the Pathogenesis of Drug-Induced Liver Injury and Emerging Therapeutic Strategies

Molecules
Drug-induced liver injury (DILI) is a common clinical pharmacogenic disease. In the United States and Europe, DILI is the most common cause of acute liver failure.
Yuqiao Huang, Yu Zhang, Kaireng Wu, Xinxin Tan, Tian Lan, Guixiang Wang   +5 more
doaj   +1 more source

Rivaroxaban-induced hepatotoxicity: review of the literature and report of new cases [PDF]

, 2018
Aim/Objective/Background Direct-acting oral anticoagulant drugs are marketed worldwide for the primary and secondary prevention and treatment of thromboembolic disorders.
Almasio, Pier Luigi, Giannitrapani, Lydia, Licata, Anna, Lombardo, Vania, Minissale, Maria G, Montalto, Giuseppe, Morreale, Ilaria, Puccia, Fania, Serruto, Antonietta, Soresi, Maurizio   +9 more
core   +1 more source

The Incidence and Risk Factor Analysis of Drug Induced Liver Injury (Dili) in a Surabaya Hospital [PDF]

, 2018
The research has been conducted on the incident and analysis of risk factors drug liver injury (DILI) in a Surabaya Hospital. The aim of this study was to determine the incident of DILI, know which drugs cause DILI, and see the association of risk ...
Arrang, S. T. (Sherly), Widyati, W. (Widyati)   +1 more
core  

Paracetamol-induced liver injury modelled in Xenopus laevis embryos [PDF]

, 2019
Introduction: Failure to predict drug-induced liver injury (DILI) remains a major contributing factor to lead compound drop-out during drug development. Xenopus embryos are amenable for early stage medium throughput small molecule screens and so have the
Saide, Katy, Sherwood, Victoria, Wheeler, Grant N.   +2 more
core   +3 more sources

The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report

Frontiers in Pharmacology
Idiosyncratic hepatotoxicity is a type of drug-induced liver injury (DILI) that is unpredictable and clinically severe, and amoxicillin clavulanate (AC) is the most implicated drug in DILI worldwide. The clinical manifestations of amoxicillin clavulanate-
Yan Zhan, Yan Zhan, Yan Zhan, Yan Zhan, Jin-Mao Liao, Ling Ye, Ling Ye, Ling Ye, Ling Ye, Long Zhang, Long Zhang, Long Zhang, Long Zhang, Long Zhang, Zheng Zhang, Ji-Ye Yin, Ji-Ye Yin, Ji-Ye Yin, Ji-Ye Yin   +18 more
doaj   +1 more source

Research progress of mitochondrial dysfunction in drug-induced liver injury [PDF]

Yixue xinzhi zazhi
Drug-induced liver injury (DILI) is a type of drug-induced liver injury with complex and diverse mechanisms that can lead to liver failure in severe cases, thereby affecting patients' quality of life and survival.
SUN Huijuan, HU Wenkai, LIU Shumin
doaj   +1 more source

Using free-text searching and ICD-10 codes to identify prospective patients with drug-induced liver injury [PDF]

, 2016
Drug-induced liver injury (DILI) is a rare cause of liver disease that is difficult to diagnose due to the lack of a confirmatory test. The Drug-Induced Liver Injury Network (DILIN) was developed to enroll patients with DILI to understand the clinical ...
Coffman, Cassandra
core   +1 more source

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources