Results 141 to 150 of about 12,201 (250)

Combined activities of JNK1 and JNK2 in hepatocytes protect against toxic liver injury [PDF]

, 2015
Background & Aims: c-Jun N-terminal kinase (JNK)1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated, via phosphorylation, in response to acetaminophen- or CCl4-induced liver damage; the level of
Al Masaoudi, Malika, Bechmann, Lars P., Boekschoten, Mark V., Canbay, Ali E., Cubero, Francisco Javier, Davis, Roger J., Gassler, Nikolaus, Hu, Wei, Liedtke, Christian, Luedde, Tom, Muller, Michael, Nevzorova, Yulia A., Peng, Jin, Preisinger, Christian, Trautwein, Christian, Zhao, Gang, Zoubek, Miguel Eugenio   +16 more
core   +1 more source

Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 681-694, April 2025.
ABSTRACT Acetaminophen (APAP) has been formulated as immediate‐, modified‐, and extended‐release tablets (APAP‐IR, ‐MR, and ‐ER, respectively). However, there was concern that APAP‐MR previously available in Europe could form a bezoar after a large overdose, leading to delayed absorption and atypical pharmacokinetics (PK) compared to APAP‐IR, and that ...
James J. Beaudoin, Kyunghee Yang, Brett A. Howell, Zackary Kenz, Vinal V. Lakhani, Jeffrey L. Woodhead, John C. K. Lai, Cathy K. Gelotte, Sury Sista, Evren Atillasoy   +9 more
wiley   +1 more source

Role of Gut Microecology in the Pathogenesis of Drug-Induced Liver Injury and Emerging Therapeutic Strategies

Molecules
Drug-induced liver injury (DILI) is a common clinical pharmacogenic disease. In the United States and Europe, DILI is the most common cause of acute liver failure.
Yuqiao Huang, Yu Zhang, Kaireng Wu, Xinxin Tan, Tian Lan, Guixiang Wang   +5 more
doaj   +1 more source

Insuficiência Hepática Aguda Induzida pela Trazodona e Diazepam [PDF]

, 2016
Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the
Barroso, E, Carvalhana, S, Ferreira, P, Oliveira, A, Perdigoto, R, Resende, M   +5 more
core   +1 more source

Bulevirtide Monotherapy Is Safe and Well Tolerated in Chronic Hepatitis Delta: An Integrated Safety Analysis of Bulevirtide Clinical Trials at Week 48

Liver International, Volume 45, Issue 4, April 2025.
ABSTRACT Background and Aims The safety and tolerability of bulevirtide (BLV), a novel entry inhibitor of hepatitis delta virus, were evaluated in an integrated analysis of clinical trial results from patients with chronic hepatitis delta (CHD). Methods Week 48 on‐treatment clinical and laboratory results from two Phase 2 trials (MYR203 [NCT02888106 ...
Tarik Asselah, Pietro Lampertico, Soo Aleman, Marc Bourlière, Adrian Streinu‐Cercel, Pavel Bogomolov, Viacheslav Morozov, Tatiana Stepanova, Stefan Lazar, Dmitry Manuilov, Renee‐Claude Mercier, Steve Tseng, Lei Ye, John F. Flaherty, Anu Osinusi, Ben L. Da, Grace M. Chee, Audrey H. Lau, Maurizia R. Brunetto, Heiner Wedemeyer   +19 more
wiley   +1 more source

Prediction Model of Drug-Induced Liver Injury in Patients with Pulmonary Tuberculosis: Evaluation of the Incidence and Risk Factors

Journal of Pharmaceutical Care, 2017
Introduction and objectives: Tuberculosis (TB) still remains a major health concern both in developing and developed countries. The rate of the liver injury due to anti-TB drugs in developed countries has been reported up to 4%.
Farzaneh Dastan, Behnam Dasht Bozorg, Ali Goodarzi, Jamshid Salamzadeh, Payam Tabarsi, Farzad Kobarfard, Fanak Fahimi   +6 more
doaj  

Online Domain Adaptation for Continuous Cross-Subject Liver Viability Evaluation Based on Irregular Thermal Data [PDF]

arXiv, 2020
Accurate evaluation of liver viability during its procurement is a challenging issue and has traditionally been addressed by taking invasive biopsy on liver. Recently, people have started to investigate on the non-invasive evaluation of liver viability during its procurement using the liver surface thermal images.
arxiv  

Safety of Anticoagulation When Undergoing Endoscopic Variceal Ligation: A Systematic Review and Meta‐Analysis

Liver International, Volume 45, Issue 4, April 2025.
ABSTRACT Introduction The safety of continuing anticoagulation therapy during endoscopic variceal ligation (EVL) remains controversial. We performed a systematic review and meta‐analysis to evaluate the safety of anticoagulation therapy in EVL. Methods We systematically searched four electronic databases from their inception until 1 June 2024, for ...
Jing Hong Loo, Joo Wei Ethan Quek, Jun Teck Gerald Low, Wei Xuan Tay, Le Shaun Ang, Aldo J Montano‐Loza, Juan G Abraldes, Yu Jun Wong   +7 more
wiley   +1 more source

Detective Work in Drug-Induced Liver Injury: Sometimes It Is All About Interviewing the Right Witness [PDF]

, 2010
Diagnosing drug-induced liver injury (DILI) relies on history as there are no definitive diagnostic tests. We report four cases where DILI was missed or the drug misidentified when physicians relied solely on patient ...
Barritt IV, A. Sidney, Hayashi, Paul H., Lee, Joseph   +2 more
core   +2 more sources

Death and Liver Transplantation within Two Years of Onset of Drug-Induced Liver Injury [PDF]

, 2017
Drug-induced liver injury (DILI) is an important cause of death and indication for liver transplantation (fatality). The role of DILI in these fatalities ispoorly characterized particularly when fatalities occur > 26 weeks after DILI onset.
Anania, Andrade, Bjornsson, Chalasani, Fontana, Fontana, Fontana, Fontana, Gustot, Jalan, Karvellas, Lee, Lee, Martinez, Medina-Caliz, Olson, Ostapowicz, Robles-Diaz, Rockey, Stickel, Stravitz, Zimmerman   +21 more
core   +2 more sources