Results 181 to 190 of about 6,710,280 (212)
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Role of immune reactions in drug-induced liver injury (DILI)
Drug Metabolism Reviews, 2012Although some drugs cause drug-induced liver injury (DILI) through direct damage to hepatocytes or intereference with bile secretion, others cause delayed, often idiosyncratic, DILI with clinical features, such as mild lymphocytic infiltrate, that are reminiscent of allergic reactions involving activation of the adaptive immune system. Even in cases of
Cynthia, Ju, Timothy, Reilly
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Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment
Annals of Pharmacotherapy, 2019Background: Micafungin is increasingly used in the treatment and prevention of candidiasis in hospitalized patients. Limited data are available from which to assess the risk of drug-induced liver injury (DILI) with micafungin. No studies, to date, have applied a standardized causality assessment method to the study of micafungin-associated DILI ...
Caitlin Mullins +2 more
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Drug-Induced Liver Injury (DILI) Classification and Its Application on Human DILI Risk Prediction
Methods in Pharmacology and Toxicology, 2018Huixiao Hong +2 more
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Global Epidemiology of Drug-Induced Liver Injury (DILI)
Current Hepatology Reports, 2019Drug-induced liver injury (DILI) is not an uncommon liver disease in many parts of the world. DILI is one of the most common causes of acute liver failure in most countries. The current review summarizes the global epidemiology of DILI. The number need to harm in terms of DILI due to amoxicillin-clavulanate was approximately 1 out 2300, but was higher ...
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Drug Safety, 2016
The relationship between drugs and pre-existing liver disease is complex, particularly when increased liver tests (LTs) or new symptoms emerge in patients with pre-existing liver disease during drug therapy. This requires two strategies to assess whether these changes are due to drug-induced liver injury (DILI) as a new event or due to flares of the ...
Rolf, Teschke, Gaby, Danan
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The relationship between drugs and pre-existing liver disease is complex, particularly when increased liver tests (LTs) or new symptoms emerge in patients with pre-existing liver disease during drug therapy. This requires two strategies to assess whether these changes are due to drug-induced liver injury (DILI) as a new event or due to flares of the ...
Rolf, Teschke, Gaby, Danan
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Role of Genetic Polymorphisms in Drug-Induced Liver Injury (DILI)
Journal of Pharmacology, Genetics and Molecular BiologyA major cause of acute liver failure and drug reaction, drug induced liver injury (DILI) usually has a genetic component. This paper discusses the effect of genetic polymorphisms as a risk factor of DILI with reference to different inbred and genetically altered mouse models.
Srikumar Chakravarthi +4 more
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Steatosis as risk factor for drug-induced liver injury (DILI)
Toxicology Letters, 2021R. Kostadinova +5 more
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Pulmonary Tuberculosis with Pneumonia, Pneumoconiosis, and Drug Induced Liver Injury (DILI)
Lombok Medical JournalTuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. According to the World Health Organization (WHO), TB is one of the top 10 causes of death in the world. TB is divided into pulmonary TB and extrapulmonary TB. Extra-pulmonary TB is defined as TB involving organs other than the lungs (pleura, lymph nodes, abdomen, skin ...
Ni Kadek Mega Suryantini +3 more
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Drug-induced liver injury: importance, epidemiology, and mechanisms of DILI
The Biomedical & Life Sciences Collection, 2021openaire +1 more source