Results 41 to 50 of about 12,201 (250)

Identifying Drug-Induced Liver Injury Associated With Inflammation-Drug and Drug-Drug Interactions in Pharmacologic Treatments for COVID-19 by Bioinformatics and System Biology Analyses: The Role of Pregnane X Receptor

Frontiers in Pharmacology, 2022
Of the patients infected with coronavirus disease 2019 (COVID-19), approximately 14–53% developed liver injury resulting in poor outcomes. Drug-induced liver injury (DILI) is the primary cause of liver injury in COVID-19 patients.
Jingjing Huang, Zhaokang Zhang, Chenxia Hao, Chenxia Hao, Yuzhen Qiu, Ruoming Tan, Jialin Liu, Xiaoli Wang, Wanhua Yang, Hongping Qu   +9 more
doaj   +1 more source

Genetics of drug‐induced liver injury: Current knowledge and future prospects

Clinical and Translational Science, Volume 16, Issue 1, Page 37-42, January 2023., 2023
Abstract Idiosyncratic drug‐induced liver injury (DILI) remains an important clinical problem, both during drug development and the prescription of a range of licensed drugs. Although rare, the consequences are serious. Ongoing studies on genetic risk factors for DILI, especially genomewide association studies, have resulted in the identification of a ...
Ann K. Daly
wiley   +1 more source

An Overview on the Proposed Mechanisms of Antithyroid Drugs-Induced Liver Injury [PDF]

Advanced Pharmaceutical Bulletin, 2015
Drug-induced liver injury (DILI) is a major problem for pharmaceutical industry and drug development. Mechanisms of DILI are many and varied.
Reza Heidari, Hossein Niknahad, Akram Jamshidzadeh, Mohammad Ali Eghbal, Narges Abdoli   +4 more
doaj   +1 more source

Indigenous Herbal Drug (Tinospora Cordifolia) Induced Liver Injury: A Case Report [PDF]

Bengal Physician Journal
Drug-induced liver injury (DILI) is a condition characterized by acute or chronic liver damage following the use of hepatotoxic drugs. It can be classified based on clinical presentation (hepatocellular, cholestasis, or mixed), mechanism of ...
Sounak Kumar Roy, Muniruddin SK, Subham Mondal, Sandipan Mukherjee, Santa Subhra Chatterjee   +4 more
doaj   +1 more source

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury [PDF]

, 2019
BACKGROUND & AIMS: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility.
Cirulli, Elizabeth T., Drug-Induced Liver Injury Network, Int DILI Consortium iDILIC, Laitinen, Tarja, Nicoletti, Paola   +4 more
core   +1 more source

Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach [PDF]

, 2022
Drug-induced liver injury (DILI) presentation varies biochemically and histologically. Certain drugs present quite consistent injury patterns, i.e., DILI signatures. In contrast, others are manifested as broader types of liver injury. The variety of DILI
Alvarez-Alvarez, Ismael, Andrade-Bellido, Raul Jesus, Ashby, Kristin, Chen, Minjun, González-Jiménez, Andrés, Lucena-González, MI, Suzuki, Ayako   +6 more
core   +1 more source

New classification of drug induced liver injury (DILI) in AASLD guidance: What is next? [PDF]

Hepatol Forum
Ercin CN.
europepmc   +3 more sources

Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury

Journal of Food Quality, 2021
Numerous prescribed drugs and herbal and dietary supplements have been reported to cause drug-induced acute liver injury, which is a frequent cause of acute liver failure (ALF).
Liangliang Yao, Muhammad Farrukh Nisar, Tingdong Yan, Chunpeng (Craig) Wan   +3 more
doaj   +1 more source

Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes:A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors [PDF]

, 2021
Background: Chronic consumption of the nonsteroidal anti-inflammatory drug diclofenac may induce drug-induced liver injury (DILI). The mechanism of diclofenac-induced liver injury is partially elucidated and involves mitochondrial damage.
Aguilar Mora, Fabio Alejandro, Buist-Homan, Manon, Cheng, Xiaodong, Lezoualc'h, Frank, Moshage, Han, Musheshe, Nshunge, Oun, Asmaa, Schmidt, Martina   +7 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source