Results 41 to 50 of about 12,367 (201)

Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms

Acta Pharmaceutica Sinica B, 2021
Drug-induced liver injury (DILI) is a leading reason for preclinical safety attrition and post-market drug withdrawals. Drug-induced mitochondrial toxicity has been shown to play an essential role in various forms of DILI, especially in idiosyncratic ...
Payal Rana, Michael D. Aleo, Xuerong Wen, Stephen Kogut   +3 more
doaj   +1 more source

Drug-induced liver injury [PDF]

, 2016
Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF) in the western world. Excluding paractamol overdose, nearly all DILI encountered in the clinical setting is idiosyncratic in nature, since affected individuals ...
A, Amacher, Chalasani, Chen, Chien, El Sherrif, Hillman, Maggi, Russo, Sakaan, Studniarz, Suk, Yeong   +12 more
core   +1 more source

Combined activities of JNK1 and JNK2 in hepatocytes protect against toxic liver injury [PDF]

, 2015
Background & Aims: c-Jun N-terminal kinase (JNK)1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated, via phosphorylation, in response to acetaminophen- or CCl4-induced liver damage; the level of
Al Masaoudi, Malika, Bechmann, Lars P., Boekschoten, Mark V., Canbay, Ali E., Cubero, Francisco Javier, Davis, Roger J., Gassler, Nikolaus, Hu, Wei, Liedtke, Christian, Luedde, Tom, Muller, Michael, Nevzorova, Yulia A., Peng, Jin, Preisinger, Christian, Trautwein, Christian, Zhao, Gang, Zoubek, Miguel Eugenio   +16 more
core   +1 more source

A Comprehensive Review on the Use of Herbal Dietary Supplements in the USA, Reasons for Their Use, and Review of Potential Hepatotoxicity

Livers, 2022
Herbal and dietary supplement (HDS) use has grown exponentially in the United States. Unfortunately, the incidence of HDS-related liver injury has proportionally increased.
Adnan Khan, Kashyap Chauhan, Heather Ross, Natalia Salinas Parra, John Magagna, Makala Wang, Patrick Zhu, Ryan Erwin, Dina Halegoua-DeMarzio   +8 more
doaj   +1 more source

Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury [PDF]

, 2015
Drug-induced liver injury (DILI) is a major concern for public health, as well as for drug development in the pharmaceutical industry, since it can cause liver failure and lead to drug withdrawal from the market and black box warnings.
Kim, Seung-Hyun, Naisbitt, Dean J
core   +1 more source

Clinical Characteristics of Patients with Drug-induced Liver Injury

Chinese Medical Journal, 2017
Background: Drug is an important cause of liver injury and accounts for up to 40% of instances of fulminant hepatic failure. Drug-induced liver injury (DILI) is increasing while the diagnosis becomes more difficult.
Li-Xia Yang, Cheng-Yuan Liu, Lun-Li Zhang, Ling-Ling Lai, Ming Fang, Chong Zhang   +5 more
doaj   +1 more source

Amoxicillin-Clavulanate-Induced Liver Injury [PDF]

, 2016
Background and Aims Amoxicillin–clavulanate (AC) is the most frequent cause of idiosyncratic drug-induced injury (DILI) in the US DILI Network (DILIN) registry.
Andrew S. deLemos, David E. Kleiner, Don C. Rockey, Herbert L. Bonkovsky, Huiman X. Barnhart, Jiezhun Gu, Marwan Ghabril, null null, Robert J. Fontana   +8 more
core   +1 more source

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study [PDF]

, 2015
BACKGROUND & AIMS: The Drug-Induced Liver Injury Network is conducting a prospective study of patients with DILI in the United States. We present characteristics and subgroup analyses from the first 1257 patients enrolled in the study.
Barnhart, Huiman, Bonkovsky, Herbert L, Chalasani, Naga, Fontana, Robert, Gu, Jiezhun, Lee, William, Navarro, Victor, Reddy, K Rajendar, Serrano, Jose, Stolz, Andrew, Talwalkar, Jayant, United States Drug Induced Liver Injury Network, Watkins, Paul B   +12 more
core   +2 more sources

Late-onset isavuconazole-induced liver injury

Medical Mycology Case Reports, 2018
Antifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking.
Felix Bongomin, Isabel Rodriguez-Goncer, Carol Lorden, Akaninyene Otu, Rohit Bazaz   +4 more
doaj   +1 more source

Liver safety assessment: required data elements and best practices for data collection and standardization in clinical trials. [PDF]

, 2014
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.A workshop was convened to discuss best practices
Andrade, Raul J, Avigan, Mark I, Bjornsson, Einar S, Cooper, Charles, Lewis, James H, Merz, Michael, Pasanen, Markku, Watkins, Paul B   +7 more
core   +2 more sources