Results 61 to 70 of about 964 (152)

Pregnane X receptor in drug-induced liver injury: Friend or foe?

Liver Research, 2018
The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cell ...
Amina I. Shehu, Xiaochao Ma
doaj  

The rediscovery of HepG2 cells for prediction of drug induced liver injury (DILI)

EXCLI journal, 2014
EXCLI Journal ; Vol.
openaire   +4 more sources

Drug‐induced liver injury associated with selective androgen receptor modulators in an adolescent patient

JPGN Reports, EarlyView.
ABSTRACT Selective androgenic receptor modulators (SARMs) have similar properties to anabolic steroids but bind to androgen receptors in a tissue‐specific manner. Studies have investigated the benefits of SARMs in promoting bone and muscle growth while limiting the adverse effects of androgenic stimulation of other organs.
David J. Katibian, Laura E. Bauman, Katayoon Shayan, D. Brent Polk   +3 more
wiley   +1 more source

Clinical and Genetic Associations in Cephalosporin‐Induced Liver Injury: Insights From the Drug‐Induced Liver Injury Network

Alimentary Pharmacology &Therapeutics, EarlyView.
Cephalosporin‐induced liver injury usually presents as a self‐limited, mixed, or cholestatic hepatitis without hypersensitivity features, typically developing 1 to 4 weeks after treatment. With cefazolin, it often occurs after a single parenteral dose. A strong genetic association has been found with HLA‐A*02:01, with more severe liver injury at onset.
Raj Vuppalanchi, Yi‐Ju Li, Don C. Rockey, Dina Halegoua‐DeMarzio, Robert J. Fontana, Herbert L. Bonkovsky, Christopher Koh, Joseph Odin, Huiman Barnhart, Jay H. Hoofnagle, Drug‐Induced Liver Injury Network (DILIN)   +10 more
wiley   +1 more source

Intestinal permeability and immune‐inflammatory markers in patients with idiosyncratic drug‐induced liver injury, drug‐induced steatosis and metabolic dysfunction–associated steatotic liver disease (MASLD)

British Journal of Pharmacology, EarlyView.
Background and Purpose Adverse immuno‐inflammatory responses possibly influenced by bacterial compounds reaching the liver as a consequence of altered intestinal permeability appear to be crucial in the pathogenesis of drug‐induced liver injury and steatotic liver diseases.
Daniel E. Di Zeo‐Sánchez, Irene Díaz‐Alberola, José María Pinazo‐Bandera, Miren García‐Cortés, Judith Sanabria‐Cabrera, Mercedes Robles‐Díaz, Ismael Álvarez‐Álvarez, M. Isabel Lucena, Raúl J. Andrade, Marina Villanueva‐Paz, Camilla Stephens   +10 more
wiley   +1 more source

Development of Prediction Models for Drug-Induced Cholestasis, Cirrhosis, Hepatitis, and Steatosis Based on Drug and Drug Metabolite Structures

Frontiers in Pharmacology, 2020
Drug-induced liver injury (DILI) is one of the major reasons for termination of drug development. Due to the importance of predicting DILI in early phases of drug development, diverse in silico models have been developed to filter out DILI-causing ...
Hyun Kil Shin, Myung-Gyun Kang, Daeui Park, Daeui Park, Tamina Park, Tamina Park, Seokjoo Yoon, Seokjoo Yoon   +7 more
doaj   +1 more source

Assessment of Hemophagocytic Lympho‐Histiocytosis (HLH) in the Setting of Adult Acute Liver Failure

Journal of Viral Hepatitis, Volume 32, Issue 9, September 2025.
ABSTRACT Hemophagocytic lympho‐histiocytosis (HLH) is a life‐threatening disease, only occasionally presenting as acute liver failure (ALF) in adults. HLH is challenging to diagnose. We reviewed the ALF Study Group (ALFSG) registry for suspected HLH subjects, as well as 184 with other ALF etiologies for cases that might have been missed, assessing ...
Ahmad Anouti, Hamza Dahshi, Jody Rule, Christian Wysocki, William M. Lee, Shannan R. Tujios   +5 more
wiley   +1 more source

Acute Liver Failure Due to Etodolac, a Selective Cycloxygenase- 2 (COX -2) Inhibitor Non-Steroidal Anti-Inflammatory Drug Established by RUCAM-Based Causality Assessment

Annals of Hepatology, 2017
Drug induced liver injury is a common cause of acute liver failure (ALF). While most of these cases are due to dose dependent hepa-totoxicity with acetaminophen, idiosyncratic drug-induced liver injury (DILI) is responsible for about 15% cases of ALF ...
Sunil Taneja, Pramod Kumar, Sahaj Rathi, Ajay Duseja, Virendra Singh, Radha Krishan Dhiman, Yogesh Kumar Chawla   +6 more
doaj  

Toxin‐Induced Liver Injury Following Bear Bile Consumption in a Middle‐Aged Female in Bhutan: A Case Report

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT Consumption of bear bile can cause severe hepatotoxicity. Clinicians should consider toxin‐mediated liver injury in patients with unexplained jaundice. Early recognition, discontinuation of the offending agent, and potential use of N‐acetylcysteine and ursodeoxycholic acid may aid recovery.
Sonam Wangzin Rabjay, Thai Wangmo, Thinley Dorji   +2 more
wiley   +1 more source

Genetic Connection to Drug-Induced Liver Injury (DILI) Through Statistical Learning Methods [PDF]

, 2021
R. E. Moore, Kristin McEuen
openalex   +1 more source