Results 61 to 70 of about 12,367 (201)

Widely Targeted Liver Metabolomics Reveals Potential Biomarkers in Mice with Drug-Induced Liver Injury

Metabolites
Background: Drug-induced liver injury (DILI), a major type of adverse drug reaction, has become one of the leading causes of acute liver injury and liver failure worldwide.
Jiangning Peng, Tingting Zhao, Xuehong Zhang, Hong Wang, Hui Li, Yan Liang   +5 more
doaj   +1 more source

The Diagnosis and Manifestations of Liver Injury Secondary to Off-Label Androgenic Anabolic Steroid Use

Case Reports in Gastroenterology, 2016
Drug-induced liver injury (DILI) presents as a broad spectrum of adverse drug reactions which can range from a mild elevation in liver enzymes to fulminant liver failure.
Elena Cabb, Shanna Baltar, David Wes Powers, Karthik Mohan, Antonio Martinez, Eric Pitts   +5 more
doaj   +1 more source

Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress

Frontiers in Pharmacology, 2022
Drug-induced liver injury (DILI) is a serious clinical disease associated with reactive oxygen species (ROS) burst and subsequent inflammatory responses.
Yunrong Yang, Yunrong Yang, Min Liu, Min Liu, Tianjiao Zhao, Tianjiao Zhao, Qiaohui Chen, Qiaohui Chen, Yuqi Yang, Yuqi Yang, Shuya Wang, Shuya Wang, Jinping Zhang, Jinping Zhang, Guiming Deng, Kewei Sun, Yayun Nan, Ke Cao, Kelong Ai, Kelong Ai, Qiong Huang, Qiong Huang   +21 more
doaj   +1 more source

Incidence of drug-induced liver injury in medical inpatients [PDF]

, 2018
Objectives: Drug-induced liver injury (DILI) is a common concern. However, data on DILI epidemiology in inpatients are sparse. Methods: To investigate the incidence of DILI, we screened all patients in the pharmacoepidemiological inpatient database ...
Cavallaro, Marzia, Fattinger, Karin, Folkers, Gerd, Meier, Peter, Meier, Yvonne, Pauli-Magnus, Christiane, Roos, Malgorzata   +6 more
core  

Severe drug-induced liver injury associated with prolonged use of Linezolid [PDF]

, 2010
This study aims to describe a patient developing concomitant severe liver failure and lactic acidosis after long-term treatment with linezolid. A 55-year-old Caucasian woman developed concomitant severe liver failure and lactic acidosis after a treatment
Benoit, Dominique, De Bus, Liesbet, Depuydt, Pieter, Libbrecht, Louis, NOLLET, JOKE, Van Vlierberghe, Hans, Vandekerckhove, Linos, Vogelaers, Dirk   +7 more
core   +1 more source

Drug induced liver injury: accuracy of diagnosis in published reports

Annals of Hepatology, 2014
The diagnosis of drug induced liver injury (DILI) is based primarily on the exclusion of alternative causes. To assess the frequency of alternative causes in initially suspected DILI cases, we searched the Medline database with the following terms: drug ...
Rolf Teschke, Christian Frenzel, Albrecht Wolff, Axel Eickhoff, Johannes Schulze   +4 more
doaj   +1 more source

Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model [PDF]

, 2015
Drug induced liver injury (DILI) is an idiosyncratic adverse drug reaction leading to severe liver damage. Kupffer cells (KC) sense hepatic tissue stress/damage and therefore could be a tool for the estimation of consequent effects associated with DILI ...
Burkhardt, Britta, Damm, Georg, Kegel, Victoria, Liu, Jia L., Nüssler, Andreas K., Pfeiffer, Elisa, Seehofer, Daniel, Zeilinger, Katrin   +7 more
core   +4 more sources

Functional foods and bioactive compounds: a comprehensive review on their role in mitigating drug-induced liver injury

Frontiers in Nutrition
Drug-induced liver injury (DILI) has become a serious public health issue worldwide. Many drugs (chemotherapy drugs, fever-reducing medications, nonsteroidal anti-inflammatory drugs, immunosuppressants, antibiotics, antivirals, and antineoplastic drugs ...
Jin-Wei Zhao, Wei-Yi Zhao, Meng Zhao, Lu Yu   +3 more
doaj   +1 more source

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man [PDF]

, 2016
The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The ‘MIP-DILI’ project addresses this situation by the development of innovative preclinical test systems which are both mechanism ...
Dragovic, Sanja, Gerets, Helga H, Hewitt, Philip G, Ingelman-Sundberg, Magnus, Juhila, Satu, Park, B Kevin, Snoeys, Jan, Vermeulen, Nico PE, Weaver, Richard J   +8 more
core   +1 more source

Drug Induced Liver Injury (Dili) and Non Alcoholic Fatty Liver Disease (Nafld)

European Journal of Medical and Health Sciences, 2020
This review article includes a review of the latest literature searched on PubMed in the field of hepatotoxicity caused by drugs that have a wide daily application. The concept of the review article consists of several parts dealing with the definition of drugs induced liver injury - DILI, diagnostic challenges related to it, and the clinical spectrum ...
Goran Bokan, Nikola Malešević, Anna Licata, Zoran Mavija   +3 more
openaire   +2 more sources