Results 71 to 80 of about 964 (152)

Allograft Injury Following Nandrolone and High‐Dose Dietary Supplements Use in a Liver Transplant Recipient: A Case Report

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT This case report highlights the importance of meticulous monitoring of all medications and dietary supplements used by solid organ transplant recipients. Although the recommended daily allowances of vitamins, minerals, and herbs are generally considered safe, combining various supplement formulations can result in excessive intake, thereby ...
Mahnaz Sadat Hosseini, Simin Dashti‐Khavidaki, Monavar Talebian, Mohsen Nasiri‐Toosi, Masoomeh Safaei   +4 more
wiley   +1 more source

Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms

Acta Pharmaceutica Sinica B, 2021
Drug-induced liver injury (DILI) is a leading reason for preclinical safety attrition and post-market drug withdrawals. Drug-induced mitochondrial toxicity has been shown to play an essential role in various forms of DILI, especially in idiosyncratic ...
Payal Rana, Michael D. Aleo, Xuerong Wen, Stephen Kogut   +3 more
doaj  

Quantitative Structure–Activity Relationship Modeling and Molecular Docking Studies of TgCDPK1 Inhibitors in Toxoplasma gondii

MicrobiologyOpen, Volume 14, Issue 4, August 2025.
We computationally identified potent TgCDPK1 inhibitors, a promising drug target for Toxoplasma gondii. QSAR modeling using 152 ligands led to IC50 predictions with R² = 80.2. Molecular docking prioritized 10 ligands, with the best compound showing strong binding energy (−176.794 kcal/mol), advancing toxoplasmosis drug discovery.
Sara Lesani, Mehdi Tavalla, Gilda Eslami, Mohammad J. Boozhmehrani   +3 more
wiley   +1 more source

Immunology Highlights of Four Major Idiosyncratic DILI Subtypes Verified by the RUCAM: A New Evidence-Based Classification

Livers
Conventionally, drug-induced liver injury (DILI) exists in two types: idiosyncratic and intrinsic. Both types are classified as non-immune disorders, thereby ignoring that some iDILI cases may have an immune or autoimmune background that requires a ...
Rolf Teschke
doaj   +1 more source

Association of T‐Cell Profiles With Disease Severity, Drug‐Induced Liver Injury, and Treatment Completion in Tuberculosis

The Clinical Respiratory Journal, Volume 19, Issue 8, August 2025.
Fourteen T cell phenotypes were associated with disease severity, including the number of pulmonary cavities. Five T cell phenotypes were associated with drug‐induced liver injury (DILI). The 4‐month and 6‐month treatment groups showed a significant difference in IFN‐γ+ naïve CD8+ T cells at week 16 but not at treatment completion.
Yifan He, Xubin Zheng, Zihan Dang, Xiaohui Hao, Yidian Liu, Peng Wang, Yingying Chen, Ying Wang, Wei Sha   +8 more
wiley   +1 more source

Pathophysiological Differences and Differential Diagnosis of Autoimmune and Drug-Induced Hepatitis

Livers
Autoimmune hepatitis (AIH) and drug-induced liver injury (DILI) are major causes of liver inflammation with distinct pathophysiology but overlapping clinical features.
Nicola Zeni, Alessandro Cristofani, Salvatore Silvio Piano, Massimo Bolognesi, Antonietta Romano   +4 more
doaj   +1 more source

Drug‐induced cholestasis

Hepatology Communications, 2017
Cholestatic drug‐induced liver injury (DILI) can be a diagnostic challenge due to a large differential diagnosis, variability in clinical presentation, and lack of serologic biomarkers associated with this condition.
Vinay Sundaram, Einar S. Björnsson
doaj   +1 more source

Rare Presentation of Adult‐Onset Still's Disease Complicated by Acute Severe Hepatitis Refractory to Medical Treatment: A Case Report

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Managing adult‐onset Still's disease complicated by severe hepatitis requires vigilant monitoring and adaptable therapeutic strategies. Standard treatments such as tocilizumab and rituximab can cause adverse reactions or lose efficacy. The interplay of systemic inflammation and liver involvement highlights the need for ongoing research to find
Majed Ali, Karam Karam, Emanuel‐Youssef Dib, Elias Fiani   +3 more
wiley   +1 more source

Mechanistic insights into antiretroviral drug‐induced liver injury

Pharmacology Research & Perspectives, 2020
All classes of antiretroviral therapy (ART) have been implicated to induce adverse drug reactions such drug‐induced liver injury (DILI) and immune‐mediated adverse reactions in Human Immunodeficiency Virus (HIV) infected individuals.
Jamie N. Pillaye, Mohlopheni J. Marakalala, Nonhlanhla Khumalo, Wendy Spearman, Hlumani Ndlovu   +4 more
doaj   +1 more source

Drug-Induced Liver Injury (DILI): A Major Challenge [PDF]

Drug Research, 2021
openaire   +2 more sources