Results 71 to 80 of about 12,367 (201)

Drugs-induced liver injury associated with non-steroidal anti-inflammatory drugs: a case report and clinical insights

Alʹmanah Kliničeskoj Mediciny, 2019
Aim: To raise the awareness of general practitioners with special characteristics of the clinical manifestations of the drug-induced liver injury (DILI), which can manifest with various signs, symptoms and types of morphological injury, from asymptomatic
Yu. G. Sandler, E. V. Vinnitskaya, K. G. Saliev, S. G. Khomeriki, T. Yu. Кhaimenova   +4 more
doaj   +1 more source

Case report: Kinetics of human leukocyte antigen receptor HLA-DR during liver injury induced by potassium para-aminobenzoate as assessed for causality using the updated RUCAM

Frontiers in Pharmacology, 2022
Potassium para-aminobenzoate (POTABA) is used to treat Peyronie’s disease by decreasing fibrosis and plaque size progression. Among potential side effects, drug-induced liver injury (DILI) attributed to POTABA administration has been reported in a few ...
Marlene Plüß, Désirée Tampe, Harald Schwörer, Sebastian Christopher Benjamin Bremer, Björn Tampe   +4 more
doaj   +1 more source

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury [PDF]

, 2019
BACKGROUND & AIMS: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility.
Cirulli, Elizabeth T., Drug-Induced Liver Injury Network, Int DILI Consortium iDILIC, Laitinen, Tarja, Nicoletti, Paola   +4 more
core   +1 more source

Utility of Liver Biopsy in the Diagnosis and Management of Possible Drug-Induced Liver Injury in Patients Receiving Antituberculosis Therapy: A Retrospective Study

Infectious Disease Reports, 2023
Background: Drug-induced liver injury (DILI) secondary to ATT treatment (TB-DILI) is reported in 2–28% of patients. We present here a series of clinical cases of suspected DILI arising during antituberculosis treatment, studied with the aid of liver ...
Gina Gualano, Drieda Zace, Silvia Mosti, Paola Mencarini, Maria Musso, Raffaella Libertone, Carlotta Cerva, Delia Goletti, Alessia Rianda, Franca Del Nonno, Laura Falasca, Fabrizio Palmieri   +11 more
doaj   +1 more source

Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]

, 2018
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan, Dunn, Kenneth W., Dunn, Robert T., Morgan, Ryan E., Ryan, Jennifer, Volak, Laurie P.   +5 more
core   +1 more source

Progress in the treatment of drug-induced liver injury with natural products

Pharmacological Research, 2022
There are numerous prescription drugs and non-prescription drugs that cause drug-induced liver injury (DILI), which is the main cause of liver disease in humans around the globe. Its mechanism becomes clearer as the disease is studied further.
Yuan-kai Sun, Ya-fei Zhang, Li Xie, Fan Rong, Xing-yu Zhu, Jing Xie, Huan Zhou, Tao Xu   +7 more
doaj   +1 more source

Paracetamol-induced liver injury modelled in Xenopus laevis embryos [PDF]

, 2019
Introduction: Failure to predict drug-induced liver injury (DILI) remains a major contributing factor to lead compound drop-out during drug development. Xenopus embryos are amenable for early stage medium throughput small molecule screens and so have the
Saide, Katy, Sherwood, Victoria, Wheeler, Grant N.   +2 more
core   +3 more sources

Comparative analysis of portal hepatic infiltrating leucocytes in acute drug‐induced liver injury, idiopathic autoimmune and viral hepatitis [PDF]

, 2015
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110851/1/cei12558 ...
Bahjat, Bonkovsky, Chalasani, Cheever, Chitturi, deLemos, Doherty, Fontana, Fontana, Holt, Ishak, Jaeschke, Jost, Kaplowitz, Kelly, Kelly, Kleiner, Kleiner, Kurachi, McFarlane, Michael, Navarro, Novobrantseva, Rockey, Rubio, Suzuki, Vogel, Washington, Wasley, Winwood   +29 more
core   +1 more source

Drug induced liver injury in HIV patients on dolutegravir based antiretroviral therapy regimens in Wolaita Sodo comprehensive specialized hospital

Scientific Reports
Drug induced liver injury is the most common and life-threatening condition associated with antiretroviral therapy. Dolutegravir (DTG) based combination antiretroviral therapy (ART) is currently first line treatment for HIV infected patients in Ethiopia.
Firew Abraham, Alemayehu Toma, Tamrat Balcha, Bereket Molla Tigabu   +3 more
doaj   +1 more source

Reliability of causality assessment for drug, herbal and dietary supplement hepatotoxicity in the Drug‐Induced Liver Injury Network (DILIN) [PDF]

, 2014
Background & AimsBecause of the lack of objective tests to diagnose drug‐induced liver injury (DILI), causality assessment is a matter of debate. Expert opinion is often used in research and industry, but its test–retest reliability is unknown.
Barnhart, Huiman X., Chalasani, Naga, Davern, Timothy J., Fontana, Robert J., Hayashi, Paul H., Hoofnagle, Jay H., Reddy, K. Rajender, Rockey, Don C., Stolz, Andrew A., Talwalkar, Jayant A.   +9 more
core   +3 more sources