Recurrent drug-induced liver injury (DILI) with ciprofloxacin and amoxicillin/clavulanic
Revista Española de Enfermedades Digestivas, 2015 Ciprofloxacin and amoxicillin/clavulanic are two widely used antibiotics due to their high efficacy and few side effects. While the percentage of hepatotoxicity of these antibiotics is low, their frequent use has led to a progressive increase in the number of cases.
Jordi Sánchez-Delgado +5 more
openaire +4 more sources
Chronic Drug-Induced Liver Injury: Updates and Future Challenges
Frontiers in Pharmacology, 2021 Chronic drug-induced liver injury (DILI), defined as DILI with persistent liver injury more than one year after the first onset by the latest European guidelines, is a notable challenge globally with big issues of defining causality and establishing ...
Qiaoling Wang +6 more
doaj +1 more source
Enzyme-Based Logic Analysis of Biomarkers at Physiological Concentrations: AND Gate with Double-Sigmoid "Filter" Response [PDF]
J. Phys. Chem. B 116, 4457-4464 (2012), 2013 We report the first realization of a biomolecular AND gate function with double-sigmoid response (sigmoid in both inputs). Two enzyme biomarker inputs activate the gate output signal which can then be used as indicating liver injury, but only when both of these inputs have elevated pathophysiological concentrations, effectively corresponding to logic-1
arxiv +1 more source
A Biochemical Logic Approach to Biomarker-Activated Drug Release [PDF]
J. Mater. Chem. 22, 19709-19717 (2012), 2013 The present study aims at integrating drug-releasing materials with signal-processing biocomputing systems. Enzymes alanine transaminase (ALT) and aspartate transaminase (AST)---biomarkers for liver injury---were logically processed by a biocatalytic cascade realizing Boolean AND gate. Citrate produced in the system was used to trigger a drug-mimicking
arxiv +1 more source
Idiosyncratic Drug Induced Liver Injury in African–Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians [PDF]
, 2017 Idiosyncratic drug induced liver injury (DILI) is a rare but potentially serious liver disorder and a major cause of significant liver injury.
Ahmad, Jawad +9 more
core +2 more sources
Frontiers in Pharmacology, 2022 Potassium para-aminobenzoate (POTABA) is used to treat Peyronie’s disease by decreasing fibrosis and plaque size progression. Among potential side effects, drug-induced liver injury (DILI) attributed to POTABA administration has been reported in a few ...
Marlene Plüß +4 more
doaj +1 more source
Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury [PDF]
arXiv, 2023 During liver transplantation, ischemia-reperfusion injury (IRI) is inevitable and decreases the overall success of the surgery. While guidelines exist, there is no reliable way to quantitatively assess the degree of IRI present in the liver. Our recent study has shown a correlation between the bile-to-plasma ratio of FDA-approved sodium fluorescein (SF)
arxiv
Relationship Between Characteristics of Medications and Drug-Induced Liver Disease Phenotype and Outcome [PDF]
, 2014 Background & Aims: It is not known if specific characteristics of medication are associated with type of drug-induced liver injury (DILI) or outcome.
Chalasani, Naga +8 more
core +1 more source
Biomolecular Filters for Improved Separation of Output Signals in Enzyme Logic Systems Applied to Biomedical Analysis [PDF]
Analyt. Chem. 83, 8383-8386 (2011), 2011 Biomolecular logic systems processing biochemical input signals and producing "digital" outputs in the form of YES/NO were developed for analysis of physiological conditions characteristic of liver injury, soft tissue injury and abdominal trauma. Injury biomarkers were used as input signals for activating the logic systems.
arxiv +1 more source
Frontiers in Pharmacology, 2022 Drug-induced liver injury (DILI) is a serious clinical disease associated with reactive oxygen species (ROS) burst and subsequent inflammatory responses.
Yunrong Yang +21 more
doaj +1 more source