Results 71 to 80 of about 5,280 (85)
Some of the next articles are maybe not open access.
Global Epidemiology of Drug-Induced Liver Injury (DILI)
Current Hepatology Reports, 2019Drug-induced liver injury (DILI) is not an uncommon liver disease in many parts of the world. DILI is one of the most common causes of acute liver failure in most countries. The current review summarizes the global epidemiology of DILI. The number need to harm in terms of DILI due to amoxicillin-clavulanate was approximately 1 out 2300, but was higher ...
openaire +2 more sources
Critical Reviews in Toxicology, 2017
Drug-induced liver injury (DILI) is a major safety issue during drug development, as well as the most common cause for the withdrawal of drugs from the pharmaceutical market. The identification of DILI biomarkers is a labor-intensive area. Conventional biomarkers are not specific and often only appear at significant levels when liver damage is ...
Araújo, Ana Margarida +4 more
openaire +4 more sources
Drug-induced liver injury (DILI) is a major safety issue during drug development, as well as the most common cause for the withdrawal of drugs from the pharmaceutical market. The identification of DILI biomarkers is a labor-intensive area. Conventional biomarkers are not specific and often only appear at significant levels when liver damage is ...
Araújo, Ana Margarida +4 more
openaire +4 more sources
Drug Safety, 2016
The relationship between drugs and pre-existing liver disease is complex, particularly when increased liver tests (LTs) or new symptoms emerge in patients with pre-existing liver disease during drug therapy. This requires two strategies to assess whether these changes are due to drug-induced liver injury (DILI) as a new event or due to flares of the ...
Gaby Danan, Rolf Teschke
openaire +3 more sources
The relationship between drugs and pre-existing liver disease is complex, particularly when increased liver tests (LTs) or new symptoms emerge in patients with pre-existing liver disease during drug therapy. This requires two strategies to assess whether these changes are due to drug-induced liver injury (DILI) as a new event or due to flares of the ...
Gaby Danan, Rolf Teschke
openaire +3 more sources
DRUG-INDUCED LIVER INJURY-DILI AND HILI IN CLINICAL PRACTICE
Drug-induced liver damage is still a problem for modern medicine. On the one hand, it is related tothe polyprogression found mainly in the elderly and chronically ill, and on the other hand, to thefashion for young people to use dietary supplements and herbs. The course of DILI can range froma mild, asymptomatic, reversible increase in liver parametersRajewski, Paweł +2 more
openaire +1 more source
Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies
Journal of Medicinal Chemistry, 2020Adverse drug reactions (ADRs) are a common cause of attrition in drug discovery and development and drug-induced liver injury (DILI) is a leading cause of preclinical and clinical drug terminations. This perspective outlines many of the known DILI mechanisms and assessment methods used to evaluate and mitigate DILI risk.
openaire +3 more sources
Steatosis as risk factor for drug-induced liver injury (DILI)
Toxicology Letters, 2021A. Wolf +5 more
openaire +2 more sources
Drug-induced liver injury (DILI)
2012Stefan Russmann, Gerd A. Kullak-Ublick
openaire +2 more sources
Reply: Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment
Annals of Pharmacotherapy, 2020Caitlin Mullins +2 more
openaire +2 more sources
A Case Report of Rifampin Alone Drug Induced Liver Injury (DILI)
American Journal of Gastroenterology, 2018Ashina D. Singh +2 more
openaire +2 more sources
Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Research
2018Neil Kaplowitz, Nabil Noureddin
openaire +2 more sources