Results 81 to 90 of about 74,202 (303)

International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol [PDF]

, 2015
Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy.
A Bathen-Noethen, A Ciantis De, A Pakozdy, AA Raymond, AJ Hall, AK Shah, Akos Pakozdy, AM McIntosh, Andrea Fischer, Andrea Tipold, AR Deibler, CJ Abramson, Clare Rusbridge, DK Thompson, E Wagner, Edward E. Patterson, EJ Ives, EL So, F Cendes, F Rosenow, GS Berns, GS Berns, H Goldberg, Heidrun Potschka, Holger A. Volk, I Craven, J Laothamatas, J Oertzen Von, J Velmurugan, J Wellmer, J Wellmer, Jacques Penderis, Jelena Jovanovik, JS Duncan, JW Wheless, K Ono, Karen Muñana, Kaspar Matiasek, KL Stadler, KM Casey, KM Fiest, L Gygax, L Heske, L Kearsley-Fleet, LM Mellema, LS Garosi, Luisa De Risio, M Guye, M Konar, M Schwartz, Marjorie Milne, ME Milne, Mette Berendt, Michael Podell, MJ Fernandes, MS Anaya Garcia, N Farid, N Ogata, NK Focke, O Jacqmot, P Singh, P Szmuk, PF Cook, PM Smith, PT Wei, R Goncalves, R Kuzniecky, R Neppl, R Vasta, R Viitmaa, R Viitmaa, RA Thames, RL Wolf, Robyn G. Farqhuar, S Hecht, S Mizoguchi, S Torisu, Sam Long, SD Shorvon, Simon Platt, Sofie F. M. Bhatti, SP Knowler, T Guadalupe, T Hammen, T Kuwabara, TJ Oertzen von, TS Jokinen, U Ebert, V Jantti, V Martle, Veronika M. Stein, WD Gaillard, YM Lim, YS Ding, Z Haneef   +94 more
core   +6 more sources

[Drug-resistant epilepsy].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2009
Despite the introduction of many new antiepileptic drugs during recent years, about one third of the epilepsy population continue to have drug-resistant seizures. We present two hypotheses on mechanisms of drug-resistant epileptic seizures.The article is based on our own clinical experience and literature identified through a PubMed search using the ...
Karl O, Nakken, Erik, Taubøll
openaire   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]

, 2014
Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Genetic Analysis of Sodium Channel Genes in Pediatric Epilepsy Patients of Pakistan

Genetics Research, 2022
Epilepsy affects millions of people worldwide. Although antiepileptic drugs work for the majority of epileptic patients, these drugs do not work for some of the patients, subjecting them to drug-resistant epilepsy (DRE). Voltage-gated sodium channels act
Aqsa Ashfaq, Tayyaba Saleem, Nadeem Sheikh, Hafsa Maqbool   +3 more
doaj   +1 more source

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy [PDF]

, 2017
Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role in drug-resistant epilepsy. The high-mobility group box 1 (HMGB1)/TLR4 axis
Alapirtti, Tiina, Antoine, Daniel, Brodie, Martin J., Frigerio, Federica, Jenkins, Rosalind E, Jorgensen, Andrea L, Marson, Anthony Guy, Park, Brian Kevin, Peltola, Jukka, Pirmohamed, Munir, Porcu, Luca, Ravizza, Teresa, Ricci, Emanuele, Sills, Graeme John, Thippeswamy, Thimmasettappa, Tse, Karen, Vezzani, Annamaria, Walker, Lauren Elizabeth   +17 more
core   +3 more sources

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

Alterations of apparent diffusion coefficient from ultra high b‐values in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy

Epilepsia Open
Objective Subcortical nuclei such as the thalamus and striatum have been shown to be related to seizure modulation and termination, especially in drug‐resistant epilepsy.
Guixian Tang, Hailing Zhou, Chunyuan Zeng, Yuanfang Jiang, Ying Li, Lu Hou, Kai Liao, Zhiqiang Tan, Huanhua Wu, Yongjin Tang, Yong Cheng, Xueying Ling, Qiang Guo, Hao Xu   +13 more
doaj   +1 more source