Results 81 to 90 of about 2,582,050 (300)

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Alterations of apparent diffusion coefficient from ultra high b‐values in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy

Epilepsia Open
Objective Subcortical nuclei such as the thalamus and striatum have been shown to be related to seizure modulation and termination, especially in drug‐resistant epilepsy.
Guixian Tang, Hailing Zhou, Chunyuan Zeng, Yuanfang Jiang, Ying Li, Lu Hou, Kai Liao, Zhiqiang Tan, Huanhua Wu, Yongjin Tang, Yong Cheng, Xueying Ling, Qiang Guo, Hao Xu   +13 more
doaj   +1 more source

Surgery for Drug-Resistant Epilepsy in Children

New England Journal of Medicine, 2017
Neurosurgical treatment may improve seizures in children and adolescents with drug-resistant epilepsy, but additional data are needed from randomized trials.In this single-center trial, we randomly assigned 116 patients who were 18 years of age or younger with drug-resistant epilepsy to undergo brain surgery appropriate to the underlying cause of ...
Rekha, Dwivedi, Bhargavi, Ramanujam, P Sarat, Chandra, Savita, Sapra, Sheffali, Gulati, Mani, Kalaivani, Ajay, Garg, Chandra S, Bal, Madhavi, Tripathi, Sada N, Dwivedi, Rajesh, Sagar, Chitra, Sarkar, Manjari, Tripathi   +12 more
openaire   +2 more sources

Epilepsy surgery in drug resistant temporal lobe epilepsy associated with neuronal antibodies [PDF]

, 2019
We assessed the outcome of patients with drug resistant epilepsy and neuronal antibodies who underwent epilepsy surgery. Retrospective study, information collected with a questionnaire sent to epilepsy surgery centers.
Villanueva, Vicente, Gómez-Ibáñez, Asier, Asadi-Pooya, Ali A., Graus Ribas, Francesc, Sperling, Michael, Donaire Pedraza, Antonio Jesús, Wehner, Tim, Bailles, Eva, Roldán Ramos, Pedro, Rumià, Jordi, Bargalló Alabart, Núria, Pimentel, Jose, Carreño, Mar, Elisak, Martin, Setoain Perego, Xavier, Boget Llucià, Teresa, Uranga, Juan, Dalmau Obrador, Josep, Gil López, Francisco, Falip, Mercè, Bien, Christian, Aparicio, Javier, Mohanraj, Rajiv, Marusic, Petr, Pintor Pérez, Luis   +24 more
core   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Deep brain stimulation in drug-resistant epilepsy: current status and future perspectives

Chinese Journal of Contemporary Neurology and Neurosurgery
Drug-resistant epilepsy remains a major challenge in management of epilepsy, with approximately half of patients being unsuitable candidates for resective surgery.
HU Tian-qi, XIE Hu-tao, ZHANG Jian-guo
doaj   +1 more source

Assessing Strengths and Limitations of Magnetoencephalography Source Imaging With Intracerebral EEG

Advanced Science, EarlyView.
Simultaneous MEG and stereotactic EEG (SEEG) recordings provide a direct validation framework for MEG source imaging in focal epilepsy. Virtual SEEG signals derived from MEG reconstructions reveal significant agreement with intracranial measures of spike localization, resting‐state oscillations, and functional connectivity, while also identifying ...
Jawata Afnan, Maria Fratello, Francesca Bonini, Samuel Medina Villalon, Zhengchen Cai, Jean‐Marc Lina, Jean‐Michel Badier, Fabrice Bartolomei, Jean Gotman, Christian G. Bénar, Christophe Grova   +10 more
wiley   +1 more source

Current Principles in the Management of Drug-Resistant Epilepsy [PDF]

, 2022
Drug-resistant epilepsy is associated with poor health outcomes and increased economic burden. In the last three decades, various new antiseizure medications have been developed, but the proportion of people with drug-resistant epilepsy remains ...
Shlobin, Nathan, Sander, Josemir
core   +1 more source

Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course

Epilepsy and Behavior Case Reports, 2017
Septo-optic dysplasia (SOD) is a rare disorder associated with optic nerve hypoplasia, pituitary abnormalities and agenesis/dysgenesis of midline brain structures including the septum pellucidum and corpus callosum.
Mashael AlKhateeb, Richard McLachlan, Jorge Burneo, David Diosy, Seyed Mirsattari   +4 more
doaj   +1 more source

Genetic Analysis of Sodium Channel Genes in Pediatric Epilepsy Patients of Pakistan

Genetics Research, 2022
Epilepsy affects millions of people worldwide. Although antiepileptic drugs work for the majority of epileptic patients, these drugs do not work for some of the patients, subjecting them to drug-resistant epilepsy (DRE). Voltage-gated sodium channels act
Aqsa Ashfaq, Tayyaba Saleem, Nadeem Sheikh, Hafsa Maqbool   +3 more
doaj   +1 more source