Results 101 to 110 of about 86,450 (250)

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Association of bacteriomes with drug susceptibility in lesions of pulmonary tuberculosis patients

Heliyon
Understanding how the bacteriomes in tuberculous lesions can be influenced by the susceptibility of Mycobacterium tuberculosis (MTB) can provide valuable information for preventing and treating drug resistant tuberculosis (DR-TB).
Weili Du, Yingli Zhao, Chen Zhang, Li Zhang, Lijuan Zhou, Zuyu Sun, Xiaojie Huang, Nana Zhang, Zichen Liu, Kun Li, Nanying Che   +10 more
doaj   +1 more source

Guselkumab Safety in Patients With Latent Tuberculosis: Analysis of 11 Studies in Psoriatic Disease

The Journal of Dermatology, EarlyView.
ABSTRACT Certain psoriatic disease treatments, including tumor necrosis factor‐α inhibitors (TNFi), increase tuberculosis (TB) risk. Testing for latent TB infection (LTBI) before initiating systemic therapy has been standard practice for psoriasis (PsO) patients; however, updated consensus states routine testing is not required before initiating ...
Luis Puig, Tsen‐Fang Tsai, Enrique R. Soriano, Tina Bhutani, Megan Miller, Alexa P. Kollmeier, Shu Li, Hewei Li, Sarah Ofori, Jeffrey Pawlikowski, Elizabeth Adamson, Melinda Gooderham, Angela Londoño Garcia, Mark Lebwohl, Peter Nash   +14 more
wiley   +1 more source

Stakeholders' perspectives on integrating point‐of‐care diagnostics into forensic death investigations in South Africa

Journal of Forensic Sciences, EarlyView.
Abstract Unnatural and unexplained deaths present critical challenges to the criminal justice, medico‐legal, and public health systems. This study explored forensic professionals' perspectives on the integration of point‐of‐care (POC) diagnostics into unnatural death investigations in South Africa.
Sebueng Ramatsokotla, Bathabile Soul, Kuhlula Maluleke, Lucinda Evert, Stefan Jansen van Vurren, Bettina Chale‐Matsau, Susan Mabotja, Evans Duah, Tivani Mashamba‐Thompson   +8 more
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Innowave MTB/RIF/INH facilitates timely and accurate diagnosis of multiple-drug resistant tuberculosis as a near POCT technique: a multicenter prospective on-site performance evaluation study

Annals of Clinical Microbiology and Antimicrobials
Background Many rifampicin (RIF)-resistant (RR) tuberculosis (TB) patients remain sensitive to isoniazid (INH), which challenges the strategy of using RR as an instant indicator of multiple-drug resistance tuberculosis (MDR-TB).
Fen Wang, Long Cai, Zhongfeng Cui, Guanglu Jiang, Hairong Huang   +4 more
doaj   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Urine Microalbuminuria in Obese Comparing with Healthy Children

Caspian Journal of Health Research, 2020
Background: Obesity is a global problem and is associated with pathophysiological mechanisms related to kidneys which may result in microalbuminuria. The aim of this study was to compare the microalbuminuria in obese and normal-weight children.
Manijeh Khalili, Simin Sadeghi-Bojd, Alireza Teimouri, Mohaddeseh Shahraki   +3 more
doaj  

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

CLINICO–Demographic Profile and Outcomes of Hospitalised Children With Diphtheria in A Tertiary Care Hospital of Peshawar

Acta Paediatrica, EarlyView.
ABSTRACT Aim To determine the clinico‐demographic profile and predictors of mortality in hospitalised children with diphtheria. Methods This retrospective cohort study included 202 children aged 5–16 years diagnosed with diphtheria per WHO criteria at Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Data on demographics, vaccination
Amir Muhammad, Ashfaq Ahmed, Waqas Naseem, Ale Azad Othman, Mohsin Hassan, Lyaba Atta, Muhammad Tahir   +6 more
wiley   +1 more source