Results 91 to 100 of about 4,201,815 (397)

Understanding Addiction as a Developmental Disorder: An Argument for a Developmentally Informed Multilevel Approach [PDF]

, 2015
Substance abuse and drug addiction are two of the most common psychopathologies among the general population. While a host of risk factors are associated with the onset of drug abuse and drug addiction, there is a growing body of evidence pointing to the
Mayes, L, McCrory, EJ
core   +1 more source

A qualitative study of experiences with physical activity among people receiving opioid agonist therapy

Substance Abuse Treatment, Prevention, and Policy
Background Physical or mental health comorbidities are common among people with substance use disorders undergoing opioid agonist therapy. As both a preventive and treatment strategy, exercise offers various health benefits for several conditions ...
Einar Furulund, Siv-Elin Leirvåg Carlsen, Karl Trygve Druckrey-Fiskaaen, Tesfaye Madebo, Lars T Fadnes, Torgeir Gilje Lid   +5 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Addressing the Opioid Crisis in Vermont: Lessons Learned from Primary Care Physicians [PDF]

, 2016
Background: Opioid Misuse in Vermont: The number of Vermonters seeking treatment for opioid abuse is increasing, particularly in Chittenden County. Emergency department visits and deaths related to opioid misuse continue to increase, both locally and ...
Carney, Jan, Cote, Elizabeth, Henderson, Tim, MacLean, Charles, Markowitz, Molly, Petchers, Adam, Rocque, Brittany, Sheridan, Andrew, Sugiyama, Nathanial, Wyatt, Lyndsey   +9 more
core   +1 more source

Addiction, neuroscience and ethics [PDF]

, 2003
Neuroscience models have much to offer the field of addiction, but they will be self-defeating if they lead to severe restrictions on the type of neuroscience research that can conducted in future.
Carter, Lucy, Hall, W. D., Morley, K. I.
core   +1 more source

Healthy eating among people on opioid agonist therapy: a qualitative study of patients’ experiences and perspectives

BMC Nutrition
People with substance use disorders often have unhealthy diets, high in sweets and processed foods but low in nutritious items like fruits and vegetables, increasing noncommunicable disease risks.
Einar Furulund, Karl Trygve Druckrey-Fiskaaen, Siv-Elin Leirvåg Carlsen, Tesfaye Madebo, Lars T. Fadnes, Torgeir Gilje Lid   +5 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats

Neurobiology of Stress, 2021
Although opioids are potent analgesics, a consequence of chronic opioid use is hyperalgesia during withdrawal, which may contribute to opioid misuse. Dynorphin, the endogenous ligand of κ-opioid receptors (KORs), is upregulated in opioid-dependent rats ...
Renata C.N. Marchette, Adriana Gregory-Flores, Brendan J. Tunstall, Erika R. Carlson, Shelley N. Jackson, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro F. Vendruscolo   +8 more
doaj  

Introducing the early trauma inventory self report - Short form and its qualitative and quantitative validation for the Slovenian general population

Slovenian Journal of Public Health, 2020
Traumatic experience in childhood or adolescence has a significant impact on the development of chronic mental and physical conditions in adulthood.
Ristić-Ilić Jelena, Kastelic Andrej
doaj   +1 more source

Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments

Frontiers in Psychiatry, 2016
The purpose of this review is to discuss recent findings related to sex differences in behavioral dyscontrol that lead to drug addiction, and clinical implications for humans are discussed.
M. Carroll, John R. Smethells
semanticscholar   +1 more source