Cubosomes the pliant honeycombed nano-cargos in drug delivery applications [PDF]
Nanomedicine JournalCubosomes are the aqueous dispersions of lipid-based liquid-crystalline bi-continuous phases, with the inner structure comprised of triply periodic, non-intersecting, curved, bilayers folded in cubic symmetry, and are organized to form two disjoined ...
Lokesh Gupta +5 more
doaj +1 more source
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Macromolecular approaches to prevent thrombosis and intimal hyperplasia following percutaneous coronary intervention. [PDF]
, 2014 Cardiovascular disease remains one of the largest contributors to death worldwide. Improvements in cardiovascular technology leading to the current generation of drug-eluting stents, bioresorbable stents, and drug-eluting balloons, coupled with advances ...
Panitch, Alyssa, Scott, Rebecca A
core +2 more sources
Mathematical Modeling of Release Kinetics from Supramolecular Drug Delivery Systems
Pharmaceutics, 2019 Embedding of active substances in supramolecular systems has as the main goal to ensure the controlled release of the active ingredients. Whatever the final architecture or entrapment mechanism, modeling of release is challenging due to the moving ...
Constantin Mircioiu +8 more
doaj +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Fluorescence Correlation Spectroscopy as a Quantitative Tool Applied to Drug Delivery Model Systems [PDF]
, 2010 The delivery of drugs to cells is a very active area of research. Drugs are commonly believed to ameliorate illnesses. The targeted, controlled and/or enhanced uptake of the drug into cells is facilitated by loading the drug into carrier vehicles ...
Christoph Jung +5 more
core +1 more source
Indometacin loading and in vitro release properties from novel carbopol coated spherical mesoporous silica nanoparticles [PDF]
, 2013 Spherical MCM-41 silica nanosized particles were synthesized and post synthesis modified by 3-aminopropyltriethoxysilane (APTES) in order to prepare amino-functionalized carrier.
Agnes Szegedi +36 more
core +1 more source
Diffusive Mobile MC for Controlled-Release Drug Delivery with Absorbing Receiver [PDF]
arXiv, 2018 Nanoparticle drug carriers play an important role in facilitating efficient targeted drug delivery, i.e., improving treatment success and reducing drug costs and side effects. However, the mobility of nanoparticle drug carriers poses a challenge in designing drug delivery systems.
arxiv
Ab initio design of drug carriers for zoledronate guest molecule using phosphonated and sulfonated calix[4]arene and calix[4]resorcinarene host molecules [PDF]
, 2017 Monomolecular drug carriers based on calix[n]-arenes and -resorcinarenes containing the interior cavity can enhance the affinity and specificity of the osteoporosis inhibitor drug zoledronate (ZOD). In this work we investigate the suitability of nine different calix[4]-arenes and -resorcinarenes based macrocycles as hosts for the ZOD guest molecule by ...
arxiv +1 more source
Lipid-based nanoparticles: innovations in ocular drug delivery
Frontiers in Molecular BiosciencesOcular drug delivery presents significant challenges due to intricate anatomy and the various barriers (corneal, tear, conjunctival, blood-aqueous, blood-retinal, and degradative enzymes) within the eye.
Mirza Salman Baig +12 more
doaj +1 more source