Results 81 to 90 of about 415,670 (364)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Margination of Micro- and Nano-Particles in Blood Flow and its Effect on the Efficiency of Drug Delivery [PDF]
, 2014 This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014) +3 more
core
Nanoparticulate Carriers for Drug Delivery [PDF]
, 2022 Drug delivery with nanoparticulate carriers is a new and upcoming research area that is making major changes within the pharmaceutical industry. Nanoparticulate carriers are discussed, particularly, engineered nanoparticulate carriers used as drug ...
Crossen, Samantha Lokelani +1 more
core +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Biophysical characterization of DNA origami nanostructures reveals inaccessibility to intercalation binding sites [PDF]
, 2019 Intercalation of drug molecules into synthetic DNA nanostructures formed through self-assembled origami has been postulated as a valuable future method for targeted drug delivery. This is due to the excellent biocompatibility of synthetic DNA nanostructures, and high potential for flexible programmability including facile drug release into or near to ...
arxiv +1 more source
Influence of drug/lipid interaction on the entrapment efficiency of isoniazid in liposomes for antitubercular therapy: a multi-faced investigation [PDF]
arXiv, 2021 Hypothesis. Isoniazid is one of the primary drugs used in tuberculosis treatment. Isoniazid encapsulation in liposomal vesicles can improve drug therapeutic index and minimize toxic and side effects. In this work, we consider mixtures of hydrogenated soy phosphatidylcholine/phosphatidylglycerol (HSPC/DPPG) to get novel biocompatible liposomes for ...
arxiv
PharmaceuticsIn the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design.
Fatih Ciftci +5 more
doaj +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Designing Covalent Organic Framework-based Light-driven Microswimmers towards Intraocular Theranostic Applications [PDF]
arXiv, 2023 Even micromachines with tailored functionalities enable targeted therapeutic applications in biological environments, their controlled motion in biological media and drug delivery functions usually require sophisticated designs and complex propulsion apparatuses for practical applications.
arxiv
Monolayer characteristics of chitosan assembled in Langmuir films mixed with arachidic acid [PDF]
Surf. Rev. Lett. 21, 1450049 (2014), 2015 Here we report the monolayer characteristics of a biodegradable polymer chitosan using Langmuir-Blodgett film technique. Usually chitosan has not form stable monolayer film. However they form stable monolayer film when mixed with fatty acid. Our result may be useful for the biological application of chitosan mainly in drug delivery.
arxiv +1 more source