Results 11 to 20 of about 381,105 (295)

A Promising Drug Delivery: Intranasal Drug Delivery System

open access: yesInternational Journal of Pharmaceutical Sciences Review and Research, 2021
Pneumonic medication conveyance has acquired gigantic logical interest as of late and has advanced inside the setting of treatment for lung infections. Lung is an appealing climate for bio particles, which are exceptionally presented to enzymatic debasement in the gastrointestinal parcel just as hepatic corruption.
M. Srinivas, Y. Kalyani, J. V. C. Sharma
openaire   +2 more sources

Mucoadhesive drug delivery systems [PDF]

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2010
Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories:
Carvalho, Flavia Chiva   +3 more
openaire   +7 more sources

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

open access: yesDrug Delivery, 2021
Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs), act as immunogenic cell death (ICD)
Xiao-Chuan Duan   +12 more
doaj   +1 more source

Mucoadhesive drug delivery systems

open access: yesJournal of Pharmacy And Bioallied Sciences, 2011
Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for ...
Rahamatullah, Shaikh   +4 more
openaire   +5 more sources

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

open access: yesActa Pharmaceutica Sinica B, 2023
Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy. Herein, a kind of tumor cascade-targeted responsive liposome (NLG919@Lip-pep1) is developed by conjugating polypeptide ...
Chuan Hu   +8 more
doaj  

Plant Exosome-like Nanoparticles as Biological Shuttles for Transdermal Drug Delivery

open access: yesBioengineering, 2023
Exosomes act as emerging transdermal drug delivery vehicles with high deformability and excellent permeability, which can be used to deliver various small-molecule drugs and macromolecular drugs and increase the transdermal and dermal retention of drugs,
Ye Wang   +6 more
doaj   +1 more source

Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

open access: yesNature Communications, 2017
Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.
Ling Guo   +8 more
doaj   +1 more source

Improving anti-tumor activity of sorafenib tosylate by lipid- and polymer-coated nanomatrix

open access: yesDrug Delivery, 2017
In the present study, we select the Sylysia 350 (Sylysia) as mesoporous material, distearoylphosphatidylethanolamine-poly(ethylene glycol)2000 (DSPE-PEG) as absorption enhancer and hydroxy propyl methyl cellulose (HPMC) as crystallization inhibitor to ...
Yang Guo   +9 more
doaj   +1 more source

Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging

open access: yesNature Communications, 2022
Detailed quantification of nanoparticle distribution in tumor tissues can provide the prediction of drug delivery efficacy and therapeutic outcome. Here the authors develop a pH/light dual responsive monochromatic ratiometric-imaging nanoparticle which ...
Yue Yan   +13 more
doaj   +1 more source

Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles

open access: yesArtificial Cells, Nanomedicine, and Biotechnology, 2019
Aim 2-HP-β-cyclodextrin-PLGA nanoparticle complexes were prepared to enhance the aqueous humour delivery of Triamcinolone acetonide.Materials & methods Drug-loaded 2-HP-β-CD/PLGA nanoparticle complexes prepared by adapting a quasi-emulsion solvent ...
Fan Li   +12 more
doaj   +1 more source

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