Results 261 to 270 of about 464,584 (319)
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2005
Drugs, in the majority of cases, are toxic at high doses however, they must be present in the circulation for a time sufficient to reach therapeutically useful results. This is commonly achieved by repeated drug administrations, which give rise to peak and valley drug concentration. Such a method of administration has two disadvantages: on the one hand
VERONESE, FRANCESCO, CALICETI, PAOLO
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Drugs, in the majority of cases, are toxic at high doses however, they must be present in the circulation for a time sufficient to reach therapeutically useful results. This is commonly achieved by repeated drug administrations, which give rise to peak and valley drug concentration. Such a method of administration has two disadvantages: on the one hand
VERONESE, FRANCESCO, CALICETI, PAOLO
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Alginate in Drug Delivery Systems
Drug Development and Industrial Pharmacy, 2002Alginates are established among the most versatile biopolymers, used in a wide range of applications. The conventional use of alginate as an excipient in drug products generally depends on the thickening, gel-forming, and stabilizing properties. A need for prolonged and better control of drug administration has increased the demand for tailor-made ...
Hanne Hjorth, Tønnesen, Jan, Karlsen
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Mucoadhesive Drug Delivery Systems
2009The uptake of drugs is often limited by the short contact time between the formulation and the absorption membrane and by a fast washout. Using mucoadhesive polymers, however, the residence time of the dosage form on the mucosa can be significantly increased.
Juliane, Hombach +1 more
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Drug delivery systems for the eye
Expert Review of Medical Devices, 2009Topical and systemic administration of drugs to the eye is highly inefficient and there is a need for controlled, sustained release, particularly for conditions that affect the posterior segment. Various nonimplantable and implantable drug delivery devices have been developed. Colloidal carriers may allow targeted drug delivery and afford protection to
Victoria R, Kearns, Rachel L, Williams
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Polymers and Drug Delivery Systems
Current Drug Delivery, 2012In the treatment of health related dysfunctions, it is desirable that the drug reaches its site of action at a particular concentration and that this therapeutic dose range remains constant over a sufficiently long period of time to alter the process.
Gemma, Vilar +2 more
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Journal of Aerosol Medicine, 1994
Nebulizers, both jet and ultrasonic, were originally designed to convert a liquid solution into an aerosol. During recent years suspensions for nebulization have been developed and nebulized with the available devices. In-vitro comparisons of drug output from jet and ultrasonic nebulizers have shown significant differences between solutions and ...
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Nebulizers, both jet and ultrasonic, were originally designed to convert a liquid solution into an aerosol. During recent years suspensions for nebulization have been developed and nebulized with the available devices. In-vitro comparisons of drug output from jet and ultrasonic nebulizers have shown significant differences between solutions and ...
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Drug Delivery Systems. 6. Transdermal Drug Delivery
The Journal of Clinical Pharmacology, 1991Transdermal drug delivery system has been in existence for a long time. In the past, the most commonly applied systems were topically applied creams and ointments for dermatological disorders. The occurrence of systemic side‐effects with some of these formulations is indicative of absorption through the skin.
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Drug Delivery Systems 4. Implants in Drug Delivery
The Journal of Clinical Pharmacology, 1990In comparison with many of the other drug delivery systems, implantable pumps and implants for variable rate delivery are at a crude stage of development. Although exceptions exist, the typical implantable pump consists of an electromechanically complex mechanism to regulate drug delivery from a percutaneous refillable reservoir, while power to drive ...
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Drug Delivery Systems 5A. Oral Drug Delivery
The Journal of Clinical Pharmacology, 1991The two main advantages of controlled drug delivery systems are: maintenance of therapeutically optimum drug concentrations in the plasma through zero‐order release without significant fluctuations; and elimination of the need for frequent single dose administrations.
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An intraoral drug delivery system
The Journal of Prosthetic Dentistry, 1989Topical drug therapy for ulcerative and vesiculobullous diseases of the oral mucosa has generally proved unsatisfactory because of the turbulent and changing nature of the oral cavity. The construction and use of an intraoral drug delivery system using custom carriers to deliver topical medication is described.
R R, Seals +3 more
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