Results 51 to 60 of about 3,066,996 (254)

A Polyamine-Based Dinitro-Naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side Effects in vitro and in vivo

Frontiers in Chemistry, 2020
Naphthalimides, such as amonafide and mitonafide in clinical trials, have been developed as antitumor agents for orthotopic tumor. However, the serious side effects in cancer patients limit their applications.
Jing Ma, Yingguang Li, Linrong Li, Kexin Yue, Hanfang Liu, Jiajia Wang, Zhuoqing Xi, Zhuoqing Xi, Man Shi, Sihan Zhao, Qi Ma, Sitong Liu, Shudi Guo, Jianing Liu, Lili Hou, Chaojie Wang, Peng George Wang, Zhiyong Tian, Songqiang Xie   +18 more
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Advances in Cryochemistry: Mechanisms, Reactions and Applications

Molecules, 2021
It is counterintuitive that chemical reactions can be accelerated by freezing, but this amazing phenomenon was discovered as early as the 1960s. In frozen systems, the increase in reaction rate is caused by various mechanisms and the freeze concentration
Lu-Yan An, Zhen Dai, Bin Di, Li-Li Xu
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Distribution in Rat Blood and Brain of TDMQ20, a Copper Chelator Designed as a Drug-Candidate for Alzheimer’s Disease [PDF]

, 2022
Lan Huang, Yaoxun Zeng, Yongliang Li, Yingshan Zhu, Yan He, Yan Liu, Anne Robert, Bernard Meunier   +7 more
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Characteristics of drug users who do or do not have care of their children

, 2004
Aims - To compare the relative frequency of eight indicators of problem drug use and potentially adverse social circumstances in drug using parents and non-parents and to explore whether a profile based on these characteristics differs according to ...
Advisory Council on the Misuse of Drugs, Barnard, Bauman, Bays, Donmall, Famularo, Gawin, Hogan, Jeremy, Johnson, Johnson, Kandel, Kaplan-Sanoff, Kelley, Kolar, Pilowsky, Rubin, Suchman, Wilens   +18 more
core   +1 more source

Deep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery

Nature Communications
Artificial intelligence transforms drug discovery, with phenotype-based approaches emerging as a promising alternative to target-based methods, overcoming limitations like lack of well-defined targets.
Xiaochu Tong, Ning Qu, Xiangtai Kong, Shengkun Ni, Jingyi Zhou, Kun Wang, Lehan Zhang, Yiming Wen, Jiangshan Shi, Sulin Zhang, Xutong Li, Mingyue Zheng   +11 more
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Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer

Nature Communications, 2022
The kinase DYRK2 is a known oncogene but its role in prostate cancer is unexplored. Here, the authors identify DYRK2 as a target for prostate cancer with a role in invasion and they discover a specific DYRK2 inhibitor that has good pharmacokinetics and ...
Kai Yuan, Zhaoxing Li, Wenbin Kuang, Xiao Wang, Minghui Ji, Weijiao Chen, Jiayu Ding, Jiaxing Li, Wenjian Min, Chengliang Sun, Xiuquan Ye, Meiling Lu, Liping Wang, Haixia Ge, Yuzhang Jiang, Haiping Hao, Yibei Xiao, Peng Yang   +17 more
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RETRACTED: Identify Biomarkers and Design Effective Multi-Target Drugs in Ovarian Cancer: Hit Network-Target Sets Model Optimizing [PDF]

, 2022
Amir Abbas Esmaeilzadeh, Mahdis Kashian, Hayder Mahmood Salman, Marwa Fadhil Alsaffar, Mustafa Musa Jaber, Siamak Soltani, Danial Amiri Manjili, Ahmet İlhan   +7 more
openalex   +1 more source

Design, Synthesis and Anticancer Activity of a New Series of N-aryl-N′-[4-(pyridin-2-ylmethoxy)benzyl]urea Derivatives

Molecules, 2021
The development of cancer treatments requires continuous exploration and improvement, in which the discovery of new drugs for the treatment of cancer is still an important pathway.
Shicheng Hou, Shishao Liang, Chao Zhang, Yingmei Han, Jianhui Liang, Hongyu Hu, Xingeng Zhang, Chun Hu, Xiaoping Liu, Hong Zhang   +9 more
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Teaching of Critical Analysis of Drug Advertisements to Medical Students [PDF]

, 2011
Background: Medical practitioners utilize drug promotional materials from pharmaceutical companies as a major source of information especially in developing countries.
Adiga, S, Bairy, KL, Chogtu, B, Nayak, V
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Thermochemical, spectral and biological activity prediction of some methylpyridine derivatives: a computational approach

Discover Chemistry
Pyridine and its derivatives play a vital role in pharmaceutical and pesticide applications. However, prolonged exposure to pyridine can lead to significant health risks due to its ability to enter the body via inhalation and absorption.
Md. Arifur Rahman, S. M. Mehedi Afnan Rejve, Md. Ruhul Amin Niloy, Mim Afsari, Umma Hany Sawon, Fahima Akter, Rafi Ahmed Miah, Md. Byzed Hasan, Monir Uzzaman   +8 more
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