Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach. [PDF]
, 2010 To address the problem of specificity in G-protein coupled receptor (GPCR) drug discovery, there has been tremendous recent interest in allosteric drugs that bind at sites topographically distinct from the orthosteric site. Unfortunately, structure-based
Ivetac, Anthony, McCammon, J Andrew
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An academic–industrial collaboration delivering better starting points for drug discovery: new compound libraries driven by intelligent design [PDF]
, 2022 Liam R. Cox
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Patient-Reported Satisfaction and Study Drug Discontinuation: Post-Hoc Analysis of Findings from ROCKET AF. [PDF]
, 2019 IntroductionPatient-reported outcomes (PROs) and satisfaction endpoints are increasingly important in clinical trials and may be associated with treatment adherence.
Becker, Richard C +14 more
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Modulation of release kinetics by plasma polymerization of ampicillin-loaded ß-TCP ceramics [PDF]
, 2016 Beta-tricalcium phosphate (ß-TCP) bioceramics are employed in bone repair surgery. Their local implantation in bone defects puts them in the limelight as potential materials for local drug delivery.
Avilés, Marc +4 more
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Journal of ChemistryA new nicotinamide derivative, (E)-N-(4-(1-(2-(4-benzamidobenzoyl)hydrazone)ethyl)phenyl)nicotinamide, was designed as a VEGFR-2 inhibitor. Utilizing the density functional theory (DFT) calculations, the three-dimensional structure of the designed ...
Ibrahim H. Eissa +8 more
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Microparticle-based Controlled Drug Delivery Systems: From Experiments to Statistical Analysis and Design [PDF]
, 2023 Sebastian Lotter +7 more
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The effects of time valuation in cancer optimal therapies: a study of chronic myeloid leukemia [PDF]
, 2019 Background The mathematical design of optimal therapies to fight cancer is an important research field in today’s Biomathematics and Biomedicine given its relevance to formulate patient-specific treatments. Until now, however, cancer optimal therapies
Gutiérrez Díez, Pedro José
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Extending an alginate drug delivery experiment to teach computational modeling and engineering analysis to 1st year biomedical engineering students [PDF]
, 2019 Engaging biomedical engineering (BME) students in the first year has been an important part of The University of Texas at Austin’s strategy to improve student motivation, retention, and self-efficacy.
Puperi, Daniel
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Scientific ReportsSchizophrenia is a neuropsychiatric disorder with limited treatment options that have unwanted side effects. Clozapine, an atypical antipsychotic, has been used for resistant schizophrenia.
Mina Y. George +14 more
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