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Data-mining of potential antitubercular activities from molecular ingredients of traditional Chinese medicines [PDF]
PeerJ, 2014 Background. Traditional Chinese medicine encompasses a well established alternate system of medicine based on a broad range of herbal formulations and is practiced extensively in the region for the treatment of a wide variety of diseases. In recent years,
Salma Jamal +2 more
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Identification of the first highly selective inhibitor of human lactate dehydrogenase B
Scientific Reports, 2021 Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD+; it has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell proliferation ...
Sachio Shibata +8 more
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UnCorrupt SMILES: a novel approach to de novo design
Journal of Cheminformatics, 2023 Generative deep learning models have emerged as a powerful approach for de novo drug design as they aid researchers in finding new molecules with desired properties.
Linde Schoenmaker +3 more
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Scientific Reports, 2021 Accumulation of tau protein is a key pathology of age-related neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy. Those diseases are collectively termed tauopathies.
Tomohiro Onishi +8 more
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Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition
Communications Biology, 2021 Mimasu et al. report a rat full-length structure of kynurenine 3-monooxygenase (KMO) in its membrane-embedded form, complexed with two inhibitors. They find that the dimeric interface of KMO is critical for its activity. This study provides insights into
Shinya Mimasu +10 more
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Scientific Reports, 2021 Activation of the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor by angiopoietin-1 (Ang1) is critical for vascular stabilization: it promotes survival signal transduction via auto-phosphorylation and reduces ...
Yukari Koya +4 more
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Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis
Advances in Rheumatology, 2022 Objectives To assess the ability of monoclonal antibodies (mAbs) specific for fibronectin extra-domain A (FnEDA) to target diseased tissues of mouse collagen induced arthritis (mCIA) models.
Victor Z. Sun +13 more
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Conversion of Aquaculture Waste into Biomedical Wealth: Chitin and Chitosan Journey
Advances in Materials Science and Engineering, 2022 Biowaste originating from aquaculture sector represents a potential feedstock to produce value-added substances and materials like chitin and chitosan. They are the long chain polymers of N-acetylglucosamine polymers with huge industrial and biomedical ...
Jerrine Joseph +8 more
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Journal of Translational Medicine, 2016 Background Angiopoietin-2 (Ang-2), a ligand of the Tie-2 receptor, plays an important role in maintaining endothelial cells and in destabilizing blood vessels. Collateral artery growth (arteriogenesis) is a key adaptive response to arterial occlusion. It
Xiaoyong Tan +11 more
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Cheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase
The Scientific World Journal, 2014 Schistosomiasis is a neglected tropical disease caused by a parasite Schistosoma mansoni and affects over 200 million annually. There is an urgent need to discover novel therapeutic options to control the disease with the recent emergence of drug ...
Sonam Gaba +3 more
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