Results 1 to 10 of about 5,239,733 (368)
Journal of Biomedical Science, 2017 Background GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to the lack of potent and selective ...
Ann M. Decker +6 more
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Advances in covalent drug discovery
Nature reviews. Drug discovery, 2022 Covalent drugs have been used to treat diseases for more than a century, but tools that facilitate the rational design of covalent drugs have emerged more recently.
L. Boike +2 more
semanticscholar +1 more source
Molecular Brain, 2021 Aim We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation.
Chunni Zhu +12 more
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Artificial intelligence to deep learning: machine intelligence approach for drug discovery
Molecular diversity, 2021 Drug designing and development is an important area of research for pharmaceutical companies and chemical scientists. However, low efficacy, off-target delivery, time consumption, and high cost impose a hurdle and challenges that impact drug design and ...
Rohan Gupta +5 more
semanticscholar +1 more source
Computational drug discovery [PDF]
Acta Pharmacologica Sinica, 2012 Computational drug discovery is an effective strategy for accelerating and economizing drug discovery and development process. Because of the dramatic increase in the availability of biological macromolecule and small molecule information, the applicability of computational drug discovery has been extended and broadly applied to nearly every stage in ...
Si-Sheng, Ou-Yang +5 more
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Nucleic Acids Res., 2021 Drug discovery relies on the knowledge of not only drugs and targets, but also the comparative agents and targets. These include poor binders and non-binders for developing discovery tools, prodrugs for improved therapeutics, co-targets of therapeutic ...
Ying Zhou +7 more
semanticscholar +1 more source
Scientific Reports, 2022 While the prevalence of breast cancer metastasis in the brain is significantly higher in triple negative breast cancers (TNBCs), there is a lack of novel and/or improved therapies for these patients. Monoacylglycerol lipase (MAGL) is a hydrolase involved
Othman Benchama +5 more
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Plant-derived natural products for drug discovery: current approaches and prospects
The Nucleus, 2022 Nature has abundant source of drugs that need to be identified/purified for use as essential biologics, either individually or in combination in the modern medical field.
Noohi Nasim +2 more
semanticscholar +1 more source
A novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects
mAbs, 2023 Nerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons.
Yukari Koya +8 more
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Anti-obesity drug discovery: advances and challenges
Nature reviews. Drug discovery, 2021 Enormous progress has been made in the last half-century in the management of diseases closely integrated with excess body weight, such as hypertension, adult-onset diabetes and elevated cholesterol.
T. Müller +3 more
semanticscholar +1 more source