Results 41 to 50 of about 5,975,518 (353)
Plant-derived natural products for drug discovery: current approaches and prospects
The Nucleus, 2022 Nature has abundant source of drugs that need to be identified/purified for use as essential biologics, either individually or in combination in the modern medical field.
Noohi Nasim +2 more
semanticscholar +1 more source
Molecular Brain, 2021 Aim We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation.
Chunni Zhu +12 more
doaj +1 more source
Benchmarking network propagation methods for disease gene identification [PDF]
, 2019 In-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein interaction information.
Barrett, Steven J. +5 more
core +2 more sources
Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni [PDF]
, 2015 Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple ...
Altamura, Sergio +5 more
core +3 more sources
Scientific Reports, 2022 While the prevalence of breast cancer metastasis in the brain is significantly higher in triple negative breast cancers (TNBCs), there is a lack of novel and/or improved therapies for these patients. Monoacylglycerol lipase (MAGL) is a hydrolase involved
Othman Benchama +5 more
doaj +1 more source
A novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects
mAbs, 2023 Nerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons.
Yukari Koya +8 more
doaj +1 more source
Hot-spot analysis for drug discovery targeting protein-protein interactions [PDF]
, 2018 Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging.
Fernández-Recio, Juan, Rosell, Mireia
core +2 more sources
Anti-obesity drug discovery: advances and challenges
Nature reviews. Drug discovery, 2021 Enormous progress has been made in the last half-century in the management of diseases closely integrated with excess body weight, such as hypertension, adult-onset diabetes and elevated cholesterol.
T. Müller +3 more
semanticscholar +1 more source
Parasites & Vectors, 2016 Background In the fight against malaria, the discovery of chemical compounds with a novel mode of action and/or chemistry distinct from currently used drugs is vital to counteract the parasite’s known ability to develop drug resistance. Another desirable
Sabine Fletcher +6 more
doaj +1 more source
Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization
Molecules, 2022 Pueraria lobata (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that P. lobata plays an essential role in controlling cytokines.
Jiaqi Wu +9 more
doaj +1 more source