Results 51 to 60 of about 5,975,518 (353)
Plant-Derived Natural Products: A Source for Drug Discovery and Development
Drugs and Drug CandidatesFor thousands of years, nature has been a source of medical substances, and an astounding numeral of contemporary remedies have been identified from natural origins.
N. Chaachouay, L. Zidane
semanticscholar +1 more source
Antiplasmodial activity of the natural product compounds alstonine and himbeline
International Journal for Parasitology: Drugs and Drug Resistance, 2021 Malaria, caused by Plasmodium parasites, continues to be a devastating global health issue. Despite a decline in malaria related deaths over the last decade, overall progress has plateaued.
M.S.J. Arnold +5 more
doaj +1 more source
Systems analysis of host-parasite interactions. [PDF]
, 2015 Parasitic diseases caused by protozoan pathogens lead to hundreds of thousands of deaths per year in addition to substantial suffering and socioeconomic decline for millions of people worldwide.
Jamshidi, Neema +3 more
core +1 more source
LifeDrug development is expensive, time-consuming, and has a high failure rate. In recent years, artificial intelligence (AI) has emerged as a transformative tool in drug discovery, offering innovative solutions to complex challenges in the pharmaceutical ...
A. Vișan, I. Neguț
semanticscholar +1 more source
ChEMBL: a large-scale bioactivity database for drug discovery
Nucleic Acids Res., 2011 ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive compounds. These data are manually abstracted from the primary published literature on a regular basis, then further curated ...
A. Gaulton +10 more
semanticscholar +1 more source
Capturing mixture composition: an open machine-readable format for representing mixed substances
Journal of Cheminformatics, 2019 We describe a file format that is designed to represent mixtures of compounds in a way that is fully machine readable. This Mixfile format is intended to fill the same role for substances that are composed of multiple components as the venerable Molfile ...
Alex M. Clark +3 more
doaj +1 more source
Drug-Drug Interactions Among Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Medications [PDF]
, 2015 One-fourth of individuals diagnosed with the human immunodeficiency virus concomitantly have the hepatitis C virus infection. Since the discovery of highly active antiretroviral therapy, liver complications have become the leading cause of morbidity and ...
Gandhi, Mona A. +2 more
core +2 more sources
A network inference method for large-scale unsupervised identification of novel drug-drug interactions [PDF]
, 2013 Characterizing interactions between drugs is important to avoid potentially harmful combinations, to reduce off-target effects of treatments and to fight antibiotic resistant pathogens, among others.
Guimera, Roger, Sales-Pardo, Marta
core +4 more sources
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
FEBS Letters, EarlyView.Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source
Gold amides as anticancer drugs: synthesis and activity studies [PDF]
, 2013 Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery.
Amagai +34 more
core +1 more source