Results 71 to 80 of about 1,359,668 (353)
In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
Scientific ReportsDue to considerable global prevalence and high recurrence rate, the pursuit of effective new medication for epilepsy treatment remains an urgent and significant challenge. Drug repurposing emerges as a cost-effective and efficient strategy to combat this
Xiaoying Lv +5 more
doaj +1 more source
Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing [PDF]
, 2019 Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery.
Baldwin, Nicole E. +4 more
core +1 more source
FEBS Letters, EarlyView.We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio +9 more
wiley +1 more source
Why are olfactory ensheathing cell tumors so rare?
Cancer Cell International, 2019 The glial cells of the primary olfactory nervous system, olfactory ensheathing cells (OECs), are unusual in that they rarely form tumors. Only 11 cases, all of which were benign, have been reported to date.
Mariyam Murtaza +7 more
doaj +1 more source
FEBS Letters, EarlyView.Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki +4 more
wiley +1 more source
Muropeptides and muropeptide transporters impact on host immune response
Gut MicrobesIn bacteria, the cell envelope is the key element surrounding and protecting the bacterial content from mechanical or osmotic damages. It allows the selective interchanges of solutes, ions, cellular debris, and drugs between the cellular compartments and
Maria Lucia Orsini Delgado +3 more
doaj +1 more source
Communicating Our Science to Our Customers:Drug Discovery in Five Simple Experiments [PDF]
, 2017 The complexities of modern drug discovery–an interdisciplinary process that often takes years and costs billions–can be extremely challenging to explain to a public audience.
Foley, David William +1 more
core +4 more sources
ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function
FEBS Letters, EarlyView.The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran +6 more
wiley +1 more source
Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery
Molecular Medicine, 2017 Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have been largely unsuccessful, a consequence of an ...
Anju M. Philip +8 more
doaj +1 more source
Scientific Reports, 2021 Human genetic studies have linked rare coding variants in microglial genes, such as TREM2, and more recently PLCG2 to Alzheimer’s disease (AD) pathology.
Juliane Obst +7 more
doaj +1 more source