Results 71 to 80 of about 1,411,950 (341)

Innovation Experiences from Africa-Led Drug Discovery at the Holistic Drug Discovery and Development (H3D) Centre [PDF]

, 2022
Vinayak Singh, Dickson Mambwe, Constance M. Korkor, Kelly Chibale   +3 more
openalex   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Why are olfactory ensheathing cell tumors so rare?

Cancer Cell International, 2019
The glial cells of the primary olfactory nervous system, olfactory ensheathing cells (OECs), are unusual in that they rarely form tumors. Only 11 cases, all of which were benign, have been reported to date.
Mariyam Murtaza, Anu Chacko, Ali Delbaz, Ronak Reshamwala, Andrew Rayfield, Brent McMonagle, James A. St John, Jenny A. K. Ekberg   +7 more
doaj   +1 more source

Academic drug discovery: Current status and prospects [PDF]

, 2015
Introduction. The contraction in pharmaceutical drug discovery operations in the past decade has been counter-balanced by a significant rise in the number of academic drug discovery groups.
Everett, Jeremy R.
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Muropeptides and muropeptide transporters impact on host immune response

Gut Microbes
In bacteria, the cell envelope is the key element surrounding and protecting the bacterial content from mechanical or osmotic damages. It allows the selective interchanges of solutes, ions, cellular debris, and drugs between the cellular compartments and
Maria Lucia Orsini Delgado, Joao Gamelas Magalhaes, Rachel Morra, Antonietta Cultrone   +3 more
doaj   +1 more source

Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery

Molecular Medicine, 2017
Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have been largely unsuccessful, a consequence of an ...
Anju M. Philip, Youdong Wang, Antonio Mauro, Suzan El-Rass, John C. Marshall, Warren L. Lee, Arthur S. Slutsky, Claudia C. dos Santos, Xiao-Yan Wen   +8 more
doaj   +1 more source

Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA)

Scientific Reports, 2022
Triple-negative breast cancer (TNBC) is associated with high mortality due to the high expression of pro-inflammatory cytokines and lack of targeted therapies.
Othman Benchama, Michael S. Malamas, Kulkarni Praveen, Elizabeth C. Ethier, Mark K. Williams, Alexandros Makriyannis, Hava Karsenty Avraham   +6 more
doaj   +1 more source

Do Certain Anaesthetic Drugs Affect Postoperative Cancer Recurrence Rates? Implications for Drug Discovery [PDF]

, 2023
Ben Wilson, Jaideep J. Pandit
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source