Results 1 to 10 of about 1,227,223 (348)
Pharmaceutics, 2022 Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but also contributes to the high morbidity and mortality rates of cardiovascular diseases. Comprehensive testing for proarrhythmic risks of drugs has been applied in
Xiaoli Tang +3 more
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Computational Approaches in Preclinical Studies on Drug Discovery and Development
Frontiers in Chemistry, 2020 Because undesirable pharmacokinetics and toxicity are significant reasons for the failure of drug development in the costly late stage, it has been widely recognized that drug ADMET properties should be considered as early as possible to reduce failure ...
Fengxu Wu +18 more
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Two preclinical tests to evaluate anticancer activity and to help validate drug candidates for clinical trials [PDF]
Oncoscience, 2015 Current approaches to assessing preclinical anticancer activity do not reliably predict drug efficacy in cancer patients. Most of the compounds that show remarkable anticancer effects in preclinical models actually fail when tested in clinical trials. We
M. López-Lázaro
semanticscholar +8 more sources
Pre-Clinical Tools for Predicting Drug Efficacy in Treatment of Tuberculosis [PDF]
Microorganisms, 2022 Combination therapy has, to some extent, been successful in limiting the emergence of drug-resistant tuberculosis. Drug combinations achieve this advantage by simultaneously acting on different targets and metabolic pathways.
Hasmik Margaryan +3 more
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Preclinical pharmacodynamic evaluation of antibiotic nitroxoline for anticancer drug repurposing
Oncology Letters, 2016 The established urinary antibiotic nitroxoline has recently regained considerable attention, due to its potent activities in inhibiting angiogenesis, inducing apoptosis and blocking cancer cell invasion. These features make nitroxoline an excellent candidate for anticancer drug repurposing.
Shoujun Yuan +5 more
openaire +5 more sources
Biomedicines, 2023 In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold standards in the preclinical assessment of anticancer drug efficacy. 3D in vitro
Elena M. Tosca +3 more
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Регуляторные исследования и экспертиза лекарственных средств, 2023 Scientific relevance. Sound recommendations for preclinical studies of transporter- mediated pharmacokinetic interactions of medicinal products can help increase the likelihood of identifying potentially nephrotoxic and hepatotoxic medicinal products at ...
V. A. Evteev +3 more
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International Journal of Pharmaceutics, 2014 Intratympanic glucocorticoid therapy aims to reduce the side effects associated with systemic long-time therapy of inner ear diseases or traumata after cochlear implantation. For that purpose, thermoreversible hydrogels being fluid at room temperature but solid at body temperature are known to be appropriate drug delivery systems. In this work, the two
Engleder, Elisabeth +5 more
openaire +5 more sources
Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research
Pharmaceutics, 2020 Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture techniques to test in vitro anti-tumor drugs prior to in vivo testing.
Bárbara Pinto +3 more
doaj +2 more sources
Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles. [PDF]
, 2012 This study presents a new multimodal imaging approach that includes high-frequency ultrasound, fluorescence intensity, confocal, and spectral imaging to improve the preclinical evaluation of new therapeutics in vivo.
Chu, David +7 more
core +19 more sources