Results 1 to 10 of about 171,263 (267)

Human Cardiac Organoids: Advances and Prospects from Construction to Preclinical Drug Evaluation [PDF]

Cells
Drug-induced cardiotoxicity (DICT) severely hampers drug development and threatens patient safety. Together with the growing global burden of cardiovascular disease, there is an urgent need to establish more predictive preclinical models. Recently, human
Meng Chen, Tianyi Zhang, Sheng Yang, Yiru Niu, Yiling Ge, Zaozao Chen, Juan Zhang, Yuepu Pu, Zhongze Gu, Geyu Liang   +9 more
doaj   +2 more sources

Comparative evaluation of recommendations for preclinical studies of transporter-mediated drug–drug interactions

Регуляторные исследования и экспертиза лекарственных средств, 2023
Scientific relevance. Sound recommendations for preclinical studies of transporter- mediated pharmacokinetic interactions of medicinal products can help increase the likelihood of identifying potentially nephrotoxic and hepatotoxic medicinal products at ...
V. A. Evteev, N. D. Bunyatyan, E. Yu. Demchenkova, A. B. Prokofiev   +3 more
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Disease modeling and drug screening using human airway organoids: a systematic review [PDF]

Organoid, 2021
Increasing levels of fine environmental dust particles due to industrialization and emerging respiratory illnesses, such as coronavirus disease 2019, pose serious threats to human life.
Do Hyun Kim, Sung Won Kim
doaj   +1 more source

P2X7 Receptor Agonist 2′(3′)-O-(4-Benzoylbenzoyl)ATP Differently Modulates Cell Viability and Corticostriatal Synaptic Transmission in Experimental Models of Huntington’s Disease

Frontiers in Pharmacology, 2021
Huntington’s disease (HD) is a life-threatening neurodegenerative disorder. Altered levels and functions of the purinergic ionotropic P2X7 receptors (P2X7Rs) have been found in animal and cellular models of HD, suggesting their possible role in the ...
Alberto Martire, Rita Pepponi, Francesco Liguori, Cinzia Volonté, Cinzia Volonté, Patrizia Popoli   +5 more
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Lychee seed polyphenol protects blood–retinal barrier by increasing tight joint proteins and inhibiting the activation of TLR4/MYD88/NF-κB-mediated NLRP3 inflammasome

Food and Agricultural Immunology, 2021
Emerging evidence indicates that blood–retinal barrier (BRB) damage is the main cause of diabetic retinopathy (DR), and the downregulation of tight proteins (TJs) located between endothelial cells and the activation of NLRP3 inflammasome-mediated ...
Jing Wei, Xiao-Hong Xiang, Yong Tang, Da-Lian Qin, Jian-Ming Wu, Chong-Lin Yu, Wen-Qiao Qiu, An-Guo Wu, Hong-Bin Lv   +8 more
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Application of Genomics in Preclinical Drug Safety Evaluation [PDF]

Basic & Clinical Pharmacology & Toxicology, 2006
Abstract: Understanding the response of biological systems to xenobiotics is fundamental to the evaluation of drug safety. Toxicologists have traditionally gathered pathological, morphological, chemical and biochemical information from in vivo studies of preclinical species in order to assess drug safety and to determine how new drugs can be safely ...
Peter G, Lord, Alex, Nie, Michael, McMillian   +2 more
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Combination therapy with bevacizumab and a CCR2 inhibitor for human ovarian cancer: An in vivo validation study

Cancer Medicine, 2023
Background Anti‐angiogenic therapy with bevacizumab (BEV), an anti‐VEGF antibody, plays a critical role in the treatment of ovarian cancer. However, despite an encouraging initial response, most tumors become resistant to BEV over time, and a new ...
Tianyue Zhai, Takashi Mitamura, Lei Wang, Shimpei I. Kubota, Masaaki Murakami, Shinya Tanaka, Hidemichi Watari   +6 more
doaj   +1 more source

In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity

Frontiers in Pharmacology, 2022
Many medicinal plants species from European -such as Artemisia absinthium, Equisetum arvense, Lamium album, Malva sylvestris, Morus nigra, Passiflora incarnata, Frangula purshiana, and Salix alba- as well as Latin American traditions -such as Libidibia ...
Andre Luis Dias Araujo Mazzari, Mariella Guimarães Lacerda, Flora Aparecida Milton, Flora Aparecida Milton, João Augusto Mulin Montechiari Machado, Simone Batista Pires Sinoti, Anne-Soulene Toullec, Patricia Marquez Rodrigues, Francisco de Assis Rocha Neves, Luiz Alberto Simeoni, Dâmaris Silveira, Jose Maria Prieto, Jose Maria Prieto, Jose Maria Prieto   +13 more
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Advances in preclinical evaluation of experimental antibody-drug conjugates

Cancer Drug Resistance, 2021
The ability to chemically modify monoclonal antibodies with the attachment of specific functional groups has opened up an enormous range of possibilities for the targeted treatment and diagnosis of cancer in the clinic. As the number of such antibody-based drug candidates has increased, so too has the need for more stringent and robust preclinical ...
Lyons, Scott K, Plenker, Dennis, Trotman, Lloyd C   +2 more
openaire   +4 more sources

A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model

Chinese Medicine, 2021
Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China.
Qiaofeng Li, Taijin Lan, Songhua He, Weiwei Chen, Xiaolan Li, Weiquan Zhang, Ying Liu, Qiuping Zhang, Xin Chen, Yaoyao Han, Zhiheng Su, Dan Zhu, Hongwei Guo   +12 more
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