Results 31 to 40 of about 1,227,223 (348)

In vitro bactericidal activities of two novel dihydropyridine derivatives against Mycobacterium tuberculosis

Journal of Infection in Developing Countries, 2017
Introduction: Introducing new and effective antitubercular agents is important in tuberculosis control programs. In this study, the in vitro antitubercular activity of two novel 1,4-dihydropyridine derivatives (F-27, Cl-33) were screened against a total
Mehdi Zandhaghighi, Farzin Hadizadeh, Saman Soleimanpour, Zahra Meshkat, Seyed Abdolrahim Rezaee, Mohammad Derakhshan, Kiarash Ghazvini   +6 more
doaj   +1 more source

Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development

BMC Complementary Medicine and Therapies, 2021
Background The dysfunction of the thyroid gland is a common medical condition. Nowadays, patients frequently use medicinal herbs as complementary or alternative options to conventional drug treatments. These patients may benefit from treatment of thyroid
Lubov V. Krepkova, Valentina V. Bortnikova, Aleksandra N. Babenko, Praskovya G. Mizina, Vladimir A. Mkhitarov, Kathleen M. Job, Catherine M. Sherwin, Elena Y. Enioutina   +7 more
doaj   +1 more source

Study on Research and Development Status and Application of 90Y Microspheres

Journal of Isotopes, 2022
With 90Y microspheres, radioactive microspheres are perfused to tumor feeding arteries through minimally invasive intervention, and then diffused and retained in small vessels of tumor terminals along with blood flow, so as to high selectively kill tumor
GAO Jie;LIU Xiaoming;ZHOU Wenhua;WANG Hongliang;ZHAO Xiaosheng;GE Qiang;LI Jianguo
doaj  

Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876—A Less Toxic and More Potent Analogue of Bedaquiline

Molecules, 2020
Bedaquiline is a novel drug approved in 2012 by the FDA for treatment of drug-resistant tuberculosis (TB). Although it shows high efficacy towards drug-resistant forms of TB, its use has been limited by the potential for significant side effects.
Peter J. Choi, Daniel Conole, Hamish S. Sutherland, Adrian Blaser, Amy S.T. Tong, Christopher B. Cooper, Anna M. Upton, Brian D. Palmer, William A. Denny   +8 more
doaj   +1 more source

Preclinical evaluation of drugs to block inflammation-driven preterm birth [PDF]

Innate Immunity, 2016
Intrauterine inflammation, the major cause of early preterm birth, can have microbial and sterile aetiologies. We assessed in a Transwell model the anti-inflammatory efficacies of five drugs on human extraplacental membranes delivered after preterm spontaneous labour (30–34 wk).
John P. Newnham, Shaofu Li, Demelza J. Ireland, Adrian Charles, Jeffrey A. Keelan, Elizabeth Nathan, Matthew W. Kemp, Lisa F Stinson   +7 more
openaire   +2 more sources

Guidelines for the recording and evaluation of pharmaco-EEG data in man: the International Pharmaco-EEG Society (IPEG) [PDF]

, 2012
The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-EEG data in man.
BABILONI, CLAUDIO, Boeijinga PH, Brunovsky M, Drinkenburg WH, Ffytche DH, Freeman J, Hegerl U, Hirata K, IPEG Pharmaco EEG Guidelines C.o.m.m.i.t.t.e.e. Collaborators, Jobert M, Kinoshita T, Knott VJ, Lopes Da Silva FH, Matousek M, Mucci A, Nottage JF, Olbrich S, Prichep LS, Ruigt GS, Saletu B, Stancak A, Strik WK, van Gerven JM, Wilson FJ, Wise RG   +24 more
core   +1 more source

Evaluation of melanin-targeted radiotherapy in combination with radiosensitizing drugs for the treatment of melanoma [PDF]

, 2014
The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. An [131I]-labeled benzamide - [131I]MIP-1145 - selectively targets melanin, reduces melanoma tumor burden and increases survival in preclinical ...
Babich, John, Boyd, Marie, Hutchison, Sharon, Mairs, Robert, Rae, Colin, Tesson, Mathias   +5 more
core   +1 more source

The effect of natural products in animal models of temporomandibular disorders [PDF]

Journal of Applied Oral Science, 2020
Treatment of temporomandibular disorders (TMD) is a challenge for health care professionals. Therefore, new approaches have been investigated, such as the use of natural products.
Janaíne Prata OLIVEIRA, Fernando Kenji NAMPO, Marilia Trindade Santana SOUZA, Luana Mendonça CERCATO, Enilton Aparecido CAMARGO   +4 more
doaj   +1 more source

Prediction of Drug-Induced TdP Risks Using Machine Learning and Rabbit Ventricular Wedge Assay [PDF]

arXiv, 2022
The evaluation of drug-induced Torsades de pointes (TdP) risks is crucial in drug safety assessment. In this study, we discuss machine learning approaches in the prediction of drug-induced TdP risks using preclinical data. Specifically, the random forest model was trained on the dataset generated by the rabbit ventricular wedge assay.
arxiv  

A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy

Frontiers in Pharmacology, 2023
Antibody-Drug Conjugates (ADCs) represent an innovative class of potent anti-cancer compounds that are widely used in the treatment of hematologic malignancies and solid tumors.
Federico Riccardi, M. Dal Bo, P. Macor, G. Toffoli   +3 more
semanticscholar   +1 more source