Results 41 to 50 of about 284,308 (307)

Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes

Nature Communications, 2022
Nanoelectrodes for measuring intracellular action potentials suffer from issues with success rate, signal strength and fabrication. Here, the authors report on a scalable technique which creates robust nanocrown electrodes with high success rates by ...
Zeinab Jahed, Yang Yang, Ching-Ting Tsai, Ethan P. Foster, Allister F. McGuire, Huaxiao Yang, Aofei Liu, Csaba Forro, Zen Yan, Xin Jiang, Ming-Tao Zhao, Wei Zhang, Xiao Li, Thomas Li, Annalisa Pawlosky, Joseph C. Wu, Bianxiao Cui   +16 more
doaj   +1 more source

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]

, 2019
Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J, Hampel, Harald, Kapogiannis, Dimitrios, Lista, Simone, Vergallo, Andrea   +4 more
core   +2 more sources

The effect of natural products in animal models of temporomandibular disorders [PDF]

Journal of Applied Oral Science, 2020
Treatment of temporomandibular disorders (TMD) is a challenge for health care professionals. Therefore, new approaches have been investigated, such as the use of natural products.
Janaíne Prata OLIVEIRA, Fernando Kenji NAMPO, Marilia Trindade Santana SOUZA, Luana Mendonça CERCATO, Enilton Aparecido CAMARGO   +4 more
doaj   +1 more source

Decreased risk of breast cancer associated with oral bisphosphonate therapy [PDF]

, 2012
Preclinical studies and adjuvant trials using bisphosphonates have found them to have an antitumor effect. Although major advances have been made in chemoprevention strategies with selective estrogen receptor modulators and aromatase inhibitors, their ...
Brufsky, A, Mathew, A
core   +2 more sources

Preclinical translation of exosomes derived from mesenchymal stem/stromal cells. [PDF]

, 2020
Exosomes are nanovesicles secreted by virtually all cells. Exosomes mediate the horizontal transfer of various macromolecules previously believed to be cell-autonomous in nature, including nonsecretory proteins, various classes of RNA, metabolites, and ...
Anderson, Johnathon D, Elahi, Fanny M, Farwell, D Gregory, Nolta, Jan A   +3 more
core  

Phase 1 dose escalation study of the allosteric AKT inhibitor BAY 1125976 in advanced solid cancer-Lack of association between activating AKT mutation and AKT inhibition-derived efficacy [PDF]

, 2019
This open-label, phase I first-in-human study (NCT01915576) of BAY 1125976, a highly specific and potent allosteric inhibitor of AKT1/2, aimed to evaluate the safety, pharmacokinetics, and maximum tolerated dose of BAY 1125976 in patients with advanced ...
Boix, Oliver, Hess, Dagmar, Hurvitz, Sara A, Joerger, Markus, Lagkadinou, Eleni, Ma, Cynthia, Moulder, Stacy, Ocker, Matthias, Rentzsch, Christine, Rudolph, Marion, Schneeweiss, Andreas, Thiele, Silke, Tsimberidou, Apostolia M, Varga, Andrea, Wilkinson, Gary   +14 more
core   +3 more sources

Considerations in biodistribution evaluation of iPSC-derived cell therapy: A pancreatic islet cell case study

Molecular Therapy: Methods & Clinical Development
Induced pluripotent stem cells (iPSCs) have substantial transformative potential in regenerative medicine, enabling tissue repair and restoration.
Miyu Nakayama, Yuu Moriya, Hikaru Ueno, Takeshi Watanabe, Hideki Hirabayashi, Syunsuke Yamamoto   +5 more
doaj   +1 more source

Preclinical pharmacodynamic evaluation of antibiotic nitroxoline for anticancer drug repurposing

Oncology Letters, 2016
The established urinary antibiotic nitroxoline has recently regained considerable attention, due to its potent activities in inhibiting angiogenesis, inducing apoptosis and blocking cancer cell invasion. These features make nitroxoline an excellent candidate for anticancer drug repurposing.
Shoujun Yuan, Kevin Pan, Qian Zhang, Linna Li, Shanshan Wang, Dexuan Yang   +5 more
openaire   +4 more sources

Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer [PDF]

Oncotarget, 2018
Despite recent advances in treatment, breast cancer remains the second-most common cause of cancer death among American women. A greater understanding of the molecular characteristics of breast tumors could ultimately lead to improved tumor-targeted treatment options, particularly for subsets of breast cancer patients with unmet needs.
David A. Tice, Shannon Breen, Haihong Zhong, Qun Du, Ronald Herbst, Jiping Zha, Molly Reed, Karma Dacosta, Rakesh Dixit, MaryJane Hinrichs, Lee Brown, Maureen Kennedy, Darrin Sabol, Partha S. Chowdhury, Partha S. Chowdhury, Binyam Bezabeh, Zhan Xiao, Rosa A. Carrasco, Sandrina Phipps, John Meekin, Cui Chen, Joanne Ayriss, Joanne Ayriss, Emily E. Bosco, R. James Christie   +24 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source