Results 101 to 110 of about 1,220,078 (316)
, 2019 Solubility of drug molecules is related to pharmacokinetic properties such as absorption and distribution, which affects the amount of drug that is available in the body for its action.
U. Deva, Priyakumar +3 more
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Drug interaction potential of resveratrol
, 2012 Resveratrol is a naturally occurring polyphenol that is often used as a food supplement. Many positive health effects, including cardio protection, tumor suppression, and immune modulation, are associated with the intake of resveratrol.
Detampel, Pascal +3 more
core +1 more source
, 2023 Deep generative models have been the subject of immense interest in various fields of science. While seeking a molecule that favorably binds to a target is a long-established goal of drug design, various generative models have emerged to reach the goal ...
Hyeongwoo, Kim +2 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The experience of drug interaction alert system established on a regional hospital
, 2009 [[abstract]]Abstract This purpose of this study is to construct a drug interaction alert system for an outpatient Physician Order Entry System, currently executed in an outpatient department, to avoid unwanted side effects due to the reactions of mixing ...
Fam-min HOU
core
Automatic Drug-Drug Interaction Detection: A Machine Learning Approach With Maximal Frequent Sequence Extraction [PDF]
, 2011 [EN] A Drug-Drug Interaction (DDI) occurs when the effects of a drug are modified by the presence of other drugs. DDIExtraction2011 proposes a first challenge task, Drug-Drug Interaction Extraction, to compare different techniques for DDI extraction ...
Mola Velasco, Santiago Moisés +3 more
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Genotoxic activities of drug-nitrite interaction products
, 2003 At first 28 orally administered drugs, considered to be potentially nitrosatable on the basis of their chemical structure, have been nitrosated with nitrite under simulated stomach conditions.
Alpertunga, Büket, Ozhan, Gül
core +1 more source