Results 51 to 60 of about 6,568,172 (215)
Customizable Self-Microemulsifying Rectal Suppositories by Semisolid Extrusion 3D Printing
PharmaceuticsObjectives: This study aims to create an innovative self-microemulsifying drug delivery system (SMEDDS) suppository for ibuprofen (IBU) using semisolid extrusion (SSE) three-dimensional (3D) printing technology.
Hye Jin Park, Dong Wuk Kim
doaj +1 more source
Evaluation of the Peer Support Program (Student Drug Prevention) 1986-1987
, 2019 The Peer Support program is a school based program funded by the National Campaign Against Drug Abuse (NCADA) as a drug prevention strategy. Prior to the existence of the NCADA the program was funded through the NSW Drug and Alcohol Authority.
Directorate of the Drug Offensive
core +1 more source
PharmaceuticsBackground/Objectives: Paclitaxel (PTX) faces clinical limitations in melanoma treatment due to poor solubility, P-glycoprotein (P-gp)-mediated efflux, and systemic toxicity.
Jihoon Lee +5 more
doaj +1 more source
, 2023 Drug-gene interaction and druggable genes identified using the differentially expressed (DE) genes in each ML cluster.
Sudhanshu Shukla (408600) +2 more
core +1 more source
How Informative Are Drug‐Drug Interactions of Gene‐Drug Interactions?
The Journal of Clinical Pharmacology, 2016 AbstractFDA recommendations to manage polymorphic CYP‐mediated drug‐drug interactions (DDIs) and gene‐drug interactions (GDIs) are typically similar. However, DDIs may not always reliably predict GDIs because the victim drug may have multiple metabolic pathways and the perpetrator drug may affect multiple enzymes or transporters. Consequently, it is of
Chakradhar V, Lagishetty +5 more
openaire +3 more sources
National Journal of Physiology, Pharmacy and Pharmacology, 2015 Background: Drugdrug interactions (DDIs) are very common and responsible for 6%30% of the adverse drug events that will increase healthcare cost and patient outcome. Polypharmacy significantly contributes to DDIs.
Nilesh B Chavda +4 more
doaj +1 more source
Predicting Drug-Target Interactions Using Drug-Drug Interactions
PLoS ONE, 2013 Computational methods for predicting drug-target interactions have become important in drug research because they can help to reduce the time, cost, and failure rates for developing new drugs. Recently, with the accumulation of drug-related data sets related to drug side effects and pharmacological data, it has became possible to predict potential drug-
Kim, Shinhyuk, Jin, Daeyong, Lee, Hyunju
openaire +5 more sources
Pharmacodynamic Drug–Drug Interactions [PDF]
Clinical Pharmacology & Therapeutics, 2019 Pharmacodynamic drug–drug interactions (DDIs) occur when the pharmacological effect of one drug is altered by that of another drug in a combination regimen. DDIs often are classified as synergistic, additive, or antagonistic in nature, albeit these terms are frequently misused.
Jin, Niu +2 more
openaire +2 more sources
Journal of Enzyme Inhibition and Medicinal ChemistryThis study presents the first comprehensive phytochemical analysis of Hydrangea macrophylla var. acuminata leaves, resulting in the isolation of 41 secondary metabolites, including four new compounds: one phenolic (3) and three bis-iridoid glycosides (30–
Thi Ly Pham +4 more
doaj +1 more source
Drug-drug interaction-related uncontrolled glycemia
Journal of Pharmacy and Bioallied Sciences, 2017 Context: The literature of drug-drug interaction (DDI)-related uncontrolled causality, and preventability of DDI-induced UCG (HbA1c >7%) in outpatients glycemia (UCG) among outpatients with Type 2 diabetes mellitus is still limited. Aims: The aim of this
Mohamed Anwar Hammad +6 more
doaj +1 more source