Results 61 to 70 of about 6,287,371 (315)

Pharmacodynamic Drug–Drug Interactions [PDF]

Clinical Pharmacology & Therapeutics, 2019
Pharmacodynamic drug–drug interactions (DDIs) occur when the pharmacological effect of one drug is altered by that of another drug in a combination regimen. DDIs often are classified as synergistic, additive, or antagonistic in nature, albeit these terms are frequently misused.
Jin, Niu, Robert M, Straubinger, Donald E, Mager   +2 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Predicting Drug-Target Interactions Using Drug-Drug Interactions

PLoS ONE, 2013
Computational methods for predicting drug-target interactions have become important in drug research because they can help to reduce the time, cost, and failure rates for developing new drugs. Recently, with the accumulation of drug-related data sets related to drug side effects and pharmacological data, it has became possible to predict potential drug-
Kim, Shinhyuk, Jin, Daeyong, Lee, Hyunju
openaire   +5 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Western Hemisphere Drug Policy Commission [website]

, 2021
Website of the Western Hemisphere Drug Policy Commission (WHDPC), charged to "evaluate a range of US counternarcotics programs in the Americas and then make recommendations to improve them" -- including a recording and transcript of the group's hearing ...
United States. Western Hemisphere Drug Policy Commission.
core  

Phytochemical constituents of Hydrangea macrophylla var. acuminata leaves and their inhibitory activity against PTP1B and α-glucosidase

Journal of Enzyme Inhibition and Medicinal Chemistry
This study presents the first comprehensive phytochemical analysis of Hydrangea macrophylla var. acuminata leaves, resulting in the isolation of 41 secondary metabolites, including four new compounds: one phenolic (3) and three bis-iridoid glycosides (30–
Thi Ly Pham, Viet Phong Nguyen, Thi Thuy An Nguyen, Byung Sun Min, Jeong Ah Kim   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Seeing what is behind the smokescreen: A systematic review of methodological aspects of smoking interaction studies over the last three decades and implications for future clinical trials

Clinical and Translational Science, 2023
Smoking drug interaction studies represent a common approach for the clinical investigation of CYP1A2 induction. Despite this important role, they remain an “orphan topic” in the existing regulatory framework of drug interaction studies, and important ...
Robert Hermann, Amin Rostami‐Hodjegan, Ping Zhao, Isabelle Ragueneau‐Majlessi   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Compliance with national guidelines for the management of drug-drug interactions in Dutch community pharmacies. [PDF]

, 2007
Item does not contain fulltextBACKGROUND: Pharmacists contribute to the detection and prevention of drug therapy-related problems, including drug-drug interactions.
Schalekamp, T., Dep Farmaceutische wetenschappen, Smet, P.A.G.M. de, Population-based studies of drug treatment: from molecule to patient outcomes, Egberts, A.C.G., de Smet, A.G.M., Buurma, H.   +6 more
core   +1 more source